Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement

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RESEARCH PRODUCT

Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement

Philippe Camus William D. Travis Mizuki Nishino Andrew H. Limper Tobias Peikert Jarushka Naidoo Michael K. Gould Jennifer D. Possick Edward B. Garon Mina Gaga M. Patricia Rivera Catherine R. Sears Philippe R. Montgrain Sandip Pravin Patel

subject

Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Biomedical Research Lung Neoplasms medicine.medical_treatment MEDLINE NSCLC Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine polycyclic compounds medicine Carcinoma Humans Immunologic Factors Organizational Objectives 030212 general & internal medicine Adverse effect Lung cancer Societies Medical Pneumonitis American Thoracic Society Documents interstitial lung disease business.industry Interstitial lung disease Cancer Pneumonia Immunotherapy medicine.disease United States Genes cdc lung cancer 030228 respiratory system Research Design immunotherapy business hormones hormone substitutes and hormone antagonists

description

Rationale: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. Objectives: To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. Methods: A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis. Results: This statement identifies gaps in knowledge and develops potential research questions to further expand knowledge regarding risk, biologic mechanisms, clinical and radiologic presentation, and management of ICI-pneumonitis. Conclusions: Gaps in knowledge of the basic biological mechanisms of ICI-pneumonitis, coupled with a precipitous increase in the use of ICIs alone or combined with other therapies, highlight the importance in triaging research priorities for ICI-pneumonitis.

year	journal	country	edition	language
2019-09-15	American Journal of Respiratory and Critical Care Medicine

https://doi.org/10.1164/rccm.201906-1202st