Search results for "Unity"
showing 10 items of 3852 documents
Opportunistic Germination Behaviour of Gypsophila (Caryophyllaceae) in Two Priority Habitats from Semi-arid Mediterranean Steppes
2011
Gypsophila tomentosa and G. struthium are closely related species, characteristic of two European priority habitats, salt and gypsum inland steppes, respectively. Germination strategies of the two taxa were investigated in plants from two nearby populations, growing under the same climatic conditions but on different types of soil, and belonging to different plant communities. Their germination patterns were studied at five constant temperatures in darkness: 5oC, 10oC, 15oC, 20oC and 25oC, and the base temperature and the thermal time requirement were calculated. As the distribution area of both species is subjected to a Mediterranean continental climate with significant differences between…
Keratinocytes Determine Th1 Immunity during Early Experimental Leishmaniasis
2010
Experimental leishmaniasis is an excellent model system for analyzing Th1/Th2 differentiation. Resistance to Leishmania (L.) major depends on the development of a L. major specific Th1 response, while Th2 differentiation results in susceptibility. There is growing evidence that the microenvironment of the early affected tissue delivers the initial triggers for Th-cell differentiation. To analyze this we studied differential gene expression in infected skin of resistant and susceptible mice 16h after parasite inoculation. Employing microarray technology, bioinformatics, laser-microdissection and in-situ-hybridization we found that the epidermis was the major source of immunomodulatory mediat…
A novel B cell population revealed by a CD38/CD24 gating strategy: CD38−CD24− B cells in centenarian offspring and elderly people
2012
The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity. Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19(+)CD38(-)CD24(-), which we find at higher frequencie…
Génesis y resolución de conflictos relacionados con la instalación de mezquitas y oratorios: el caso del oratorio de Singuerlín (Santa Coloma de Gram…
2017
Durante los últimos años, se han sucedido, en diferentes territorios del Estado español, los conflictos relacionados con la instalación de mezquitas y oratorios destinados a la práctica del culto musulmán. Este artículo analiza uno de los conflictos más intensos, el desatado en 2004 ante el intento de apertura del oratorio del barrio de Singuerlín en Santa Coloma de Gramenet. Se estudia su raíz, su evolución y el papel que jugó la mediación intercultural en su gestión. A partir de las entrevistas en profundidad efectuadas con los actores implicados, varios años después, se analizan los elementos estructurales del conflicto y se plantea una reflexión acerca de la forma en la que se ha ido co…
Zvaigžņotā Debess: 2008, Vasara
2008
Latvijas Zinātņu akadēmija, Latvijas Universitāte
Pedagogia di comunità e pedagogie della liberazione
2014
Il tema trattato nel presente articolo riguarda il confronto tra la pedagogia di comunità e le pedagogie della liberazione, due approcci che sono accomunati dal desiderio di promuovere il risveglio collettivo di una nuova coscienza sociale e politica. Le due prospettive pedagogiche riaffermano entrambe i diritti di tutti gli esseri umani, anche degli esclusi, a divenire soggetti politici in grado di trasformare la società in direzione autenticamente democratica. Grazie alla lezione di grandi maestri come John Dewey, Paulo Freire e Aldo Capitini, la prassi educativa vissuta nei contesti comunitari genera la corresponsabilità democratica di tutti; la cura del bene comune e il rispetto non vio…
Implementation of strategies and tools of sociosanitary coordination in a health department
2018
RESUMEN Es objetivo de este artículo mostrar una experiencia de práctica novedosa implementada por la dirección de un departamento de salud. Se expone un modelo organizativo de coordinación sociosanitaria entre los diferentes niveles asistenciales y sectores, estableciendo sinergias de los recursos sociales y sanitarios comunes del Departamento de Salud Clínico-Malvarrosa (Valencia). Tras un año, se han constituido cinco consejos de salud de zona básica en atención primaria y una comisión de coordinación sociosanitaria integrada por tres subcomisiones: 1) de atención asistencial social y sanitaria, 2) de asociacionismo y voluntariado hospitalario, y 3) de acción comunitaria y participación …
The HCV Sicily Network: A web-based model for the management of HCV chronic liver diseases
2016
Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment.The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis. The network includes 41 centers and 84 gastroenterologists or infectivologists connected by a web platform that recorder the diagnosis and the clinic priority for the…
The role of embeddedness and top management teams on subsidiary initiative
2018
The importance of subsidiaries reaches its pick with their entrepreneurial role. Subsidiary initiatives (SI) are seen as “discrete, proactive undertaking that advances a new way for the corporation to use or expand its resources” (Birkinshaw, 2014, p. 203), which starts with the identification of an opportunity and should achieve the commitment of resources. Nonetheless, though initiatives are beneficial for the entire MNC (Bartlett & Ghoshal, 1988; Birkinshaw & Hood, 2000; Birkinshaw et al., 2005), they are not necessarily well receive by HQ but instead the MNC corporate immune system activates and initiative are rejected (Birkinshaw & Ridderstråle, 1999). This happens because initiatives …
Conserved TCR β chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen
2002
Previous work suggested that expanded CD8+ T-cell clones in the synovial fluid (SF) of HLA-B27+ patients with reactive arthritis (ReA) preferentially use the T-cell receptor variable region (TCRBV) 1, similar CDR3 sequences, and joining region (BJ) 2S3. To determine the range of conservation and disease-specificity of CDR3-sequences, we analyzed the TCRBV1-J2S3 repertoire from 33 healthy HLA-B27+ individuals, patients with various types of spondyloarthropathies (SpA), and with rheumatoid arthritis (RA) by CDR3-spectratyping. After collection and database submission of all available TCRB-CDR3 from HLA-B27-restricted or SpA-derived T cells, we systematically screened the entire human sequence…