Search results for "User"
showing 10 items of 1060 documents
Influence of the ovary on parameters of LH secretion during the recovery from buserelin-induced desensitization
1994
Abstract This study examined the effect of the ovary on LH pulsatility and on the secretory performance of gonadotrophes during the phase of recovery after treatment with buserelin, a GnRH analogue. We included 12 patients, who received buserelin (1.2 mg/day, intranasally for 3 months) as a reductive therapy for uterine leiomyomatosis prior to hysterectomy. Six patients were oophorectomized and the other 6 patients had their ovaries preserved. LH was measured in samples taken basally up to 36 days after suppression of buserelin. LH pulsatility was studied on day 9 along a 24-h cycle, and the response of the hormone to a double-stimulus GnRH test on days 0, 9, 20, and 34. The concentration o…
Usability issues of clinical and research applications of virtual reality in older people: A systematic review
2020
Aging is a condition that may be characterized by a decline in physical, sensory, and mental capacities, while increased morbidity and multimorbidity may be associated with disability. A wide range of clinical conditions (e.g., frailty, mild cognitive impairment, metabolic syndrome) and age-related diseases (e.g., Alzheimer's and Parkinson's disease, cancer, sarcopenia, cardiovascular and respiratory diseases) affect older people. Virtual reality (VR) is a novel and promising tool for assessment and rehabilitation in older people. Usability is a crucial factor that must be considered when designing virtual systems for medicine. We conducted a systematic review with Preferred Reporting Items…
Concomitant gonadotropin-releasing hormone agonist and menotropin treatment for the synchronized induction of multiple follicles.
1988
In an effort to overcome possible interference by endogenous gonadotropin-ovarian hormone dynamics, desensitization of the pituitary gonadotropins by a gonadotropin-releasing hormone agonist (GnRHa) was achieved in 12 women with repeatedly failed attempts at multiple follicular stimulation. Eight women were scheduled for in vitro fertilization (IVF) and embryo transfer (ET), and 4 for gamete intrafallopian transfer (GIFT). Stimulation failure was characterized by premature luteinization, poor estradiol (E2) response, or inadequate follicular growth. The agonist was administered by nasal spray 500 to 600 micrograms/day beginning on days 21 to 23 of the menstrual cycle. A rapid desensitizatio…
Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist…
2005
Background This descriptive study evaluates the impact on endometrial development of standard and high doses of a GnRH antagonist in stimulated cycles compared with GnRH agonist and natural cycles. Methods Thirty-one oocyte donors were treated with a combination of rFSH and 0.25 mg/day ganirelix (standard dose), 2 mg/day ganirelix (high dose) or 0.6 mg/day buserelin (long protocol). Vaginal progesterone (200 mg/day) was administered in the luteal phase. Endometrial biopsies were performed 2 and 7 days after HCG administration. Additional biopsies were carried out in a subset of 12 subjects, 2 and 7 days following the LH peak of their previous natural cycle. Biopsies were evaluated histologi…
Using ‘Ambient Intelligence’ for Compensating Intellectual Difficulties of People with Severe Learning Difficulties and/or Autistic Spectrum Disorders
2004
This paper describes a set of services and software created so that what is called ‘ambient intelligence’ would compensate for the ‘intellectual difficulties’ that people from this collective have. Existing concepts and standards of ambient intelligence are strongly reinforced through the use of the exact current user’s position as a key factor to calculate how the ‘digital home’ or any ‘digital environment’ behaves at every moment. This will be obtained using both Wi-Fi personal locators (embedded in necklaces or bracelets) and Wi-Fi communication from the PDA. This mix, together with individual capabilities and preferences, makes the development of a wide range of services possible when c…
The Intelligent e-Therapy system: a new paradigm for telepsychology and cybertherapy
2009
ABSTRACT One of the main drawbacks of computer-assisted psychology tools developed up to now is related to the real time customisation and adaptation of the content to each patient depending on his/her activity. In this paper we propose a new approach for mental e-health treatments named Intelligent e-Therapy (eIT) with capabilities for ambient intelligence and ubiquitous computing. From a technical point of view, an eIT system is based on four fundamental axes: ambient intelligence for capturing physiological, psychological and contextual information of the patient; persuasive computing for changing/reinforcing behaviours; ubiquitous computing for using the system at any place, and at any …
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening
2013
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.
The user’s perspective in architectural heritage
2019
Currently, the awareness has been widely acquired that appropriate use is an important condition for saving architectural heritage: as well as many others requisites (manageability, maintainability, and security) similarly accessibility has become common to any settlement, including the built heritage. Keeping in mind this general framework, the paper will outline the link between architec- tural heritage and the user’s perspective, intended as the paramount basis both of technological design and health science. The intertwined relationships between socio-cultural and economical aspects clarify the features of the use of this specific form of built environment, proposed as a thought provoki…
Agent-Oriented Captology for Anthropocentric Systems
2001
Abstract Considering that anthropo centric systems are an adequate domain for captological approaches, and that interface agents are most natural interactants for the humans involved, the paper presents a broad-spectrum generic architectural framework to support developing flexible interfaces for industrial applications, based on synergetic correlation between persuasive technologies and polymorphic agents. The design space for agent-oriented captology is defined and several of its main dimensions are elaborated upon. The main mechanisms used are dynamic priorities, "flexible cloning" and fuzzy temporal windows. Some agent-oriented test-bench applications instantiating the generic architect…
Knowledge Acquisition in Conceptual Ontological Artificial Intelligence System
2009
The paper deals with active knowledge acquisition based on dialogue between AI system and its user. Presented method uses Conceptual Ontological Object Orientated System (COOS) to distinguish differences between concepts and to unequivocally process the input stream. In case of concepts, that do not exist in the system yet, adequate algorithms are being used to position them in ontological core. Separate concepts differ in attributes values or in sets of direct connections with other concepts. The communication aspect of the system deliver information that allow generating proper interpretation for userpsilas statement.