Search results for "User"
showing 10 items of 1060 documents
Efficient virtual screening using multiple protein conformations described as negative images of the ligand-binding site.
2010
The protein structure-based virtual screening is typically accomplished using a molecular docking procedure. However, docking is a fairly slow process that is limited by the available scoring functions that cannot reliably distinguish between active and inactive ligands. In contrast, the ligand-based screening methods that are based on shape similarity identify the active ligands with high accuracy. Here, we show that the usage of negative images of the ligand-binding site, together with shape comparison tools, which are typically used in ligand-based virtual screening, improve the discrimination of active molecules from inactives. In contrast to ligand-based shape comparison, the negative …
Protein knot server: detection of knots in protein structures
2007
KNOTS (http://knots.mit.edu) is a web server that detects knots in protein structures. Several protein structures have been reported to contain intricate knots. The physiological role of knots and their effect on folding and evolution is an area of active research. The user submits a PDB id or uploads a 3D protein structure in PDB or mmCIF format. The current implementation of the server uses the Alexander polynomial to detect knots. The results of the analysis that are presented to the user are the location of the knot in the structure, the type of the knot and an interactive visualization of the knot. The results can also be downloaded and viewed offline. The server also maintains a regul…
Enhancing dynamic graphical analysis with the Lisp-Stat language and the ViSta statistical program
2005
Presented is a sample of computerized methods aimed at multidimensional scaling and psychometric item analysis that offer a dynamic graphical interface to execute analyses and help visualize the results. These methods show how the Lisp-Stat programming language and the ViSta statistical program can be jointly applied to develop powerful computer applications that enhance dynamic graphical analysis methods. The feasibility of this combined strategy relies on two main features: (1) The programming architecture of ViSta enables users to add new statistical methods as plug-ins, which are integrated into the program environment and can make use of all the functions already available in ViSta (e.…
User detection through multi-sensor fusion in an AmI scenario
2012
Recent advances in technology, with regard to sensing and transmission devices, have made it possible to obtain continuous and precise monitoring of a wide range of qualitatively diverse environments. This has boosted the research on the novel field of Ambient Intelligence, which aims at exploiting the information about the environment state in order to adapt it to the user’s preference. In this paper, we analyze the issue of detecting the user’s presence in a given region of the monitored area, which is crucial in order to trigger subsequent actions. In particular, we present a comprehensive framework that turns data perceived by sensors of different nature, and with possible imprecision, …
Humorist Bot: Bringing Computational Humour in a Chat-Bot System
2008
A conversational agent, capable to have a ldquosense of humourrdquo is presented. The agent can both generate humorous sentences and recognize humoristic expressions introduced by the user during the dialogue. Humorist Bot makes use of well founded techniques of computational humor and it has been implemented using the ALICE framework embedded into an Yahoo! Messenger client. It includes also an avatar that changes the face expression according to humoristic content of the dialogue.
Discounted Prototyping of Virtual Reality Solutions for Science Education
2017
Science education requires experimental work for learners to achieve the intended learning outcomes, which sometimes involve abstract concepts by nature. Advances in digital technology can help learners to undertake experimental work, which would otherwise be costly, either due to the scarcity of laboratory equipment or safety requirements. However, one of the major concerns resides into how to design usable learning solutions from the users’ perspective. That would require the involvement of users at all stages of design and development process, even if the technology itself could still be in its infancy. It can be very helpful to present the new design concepts to potential users at a ver…
Reading skills and children’s navigation strategies in hypertext
2011
Prior research has identified two important navigation strategies that have a clear impact on hypertext comprehension: link selection and overview processing strategies. The first relate to the order in which students select hyperlinks while trying to comprehend a hypertext, whereas the second relate to when and for how long students process navigation overviews, a text device that conveys the text structure by displaying sections, titles and their relations. Most prior research in navigation strategies has been conducted with undergraduate students. We extend prior research by exploring the navigation strategies used by sixth-graders while reading a hypermedia system. We also investigate h…
Visualization and User Interface Questions about Disability
1999
The visually impaired and the intellectually disabled are not equal groups but both groups benefit partly from the same features. Communication, symbols, pictures, customizing and alternative languages are the key elements in visualization and in user interface design to the both groups.
KIND-DAMA: A modular middleware for Kinect-like device data management
2017
Summary In the last decades, we have witnessed a growing interest toward touchless gestural user interfaces. Among other reasons, this is due to the large availability of different low-cost gesture acquisition hardware (the so-called “Kinect-like devices”). As a consequence, there is a growing need for solutions that allow to easily integrate such devices within actual systems. In this paper, we present KIND-DAMA, an open and modular middleware that helps in the development of interactive applications based on gestural input. We first review the existing middlewares for gestural data management. Then, we describe the proposed architecture and compare its features against the existing simila…
Combining traditional and indirect augmented reality for indoor crowded environments. A case study on the Casa Batlló museum
2017
Abstract Mobile audio-guides are currently being used in museums to enhance the visitors’ experience. Over the past few years, some Augmented Reality (AR) solutions have been explored in this context, making it possible to provide augmented visual and sonic stimuli through the use of smartphones. However, the special conditions of museums (e.g. artificial markers cannot be used, small, crowded rooms, etc.) and the limited computational capacity of smartphones mean that there are important restrictions in the use of this technology. In this paper we introduce a novel mobile augmented guide for the Casa Batllo museum (Barcelona, Spain) which is based on a combination of traditional and indire…