Search results for "VALIDATION"
showing 10 items of 620 documents
MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
2018
mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), th…
Micellar liquid chromatography determination of rivaroxaban in plasma and urine. Validation and theoretical aspects.
2019
A Micellar Chromatographic method to determine rivaroxaban in plasma and urine has been developed. The samples were dissolved in the mobile phase (SDS 0.05 M – 1-propanol 12.5%, phosphate buffered at pH 7) and 20 μL directly injected, avoiding the extraction and purification steps. Using a C18 column and running under isocratic mode at 1 mL/min, analyte was eluted without interference from the matrix in <6.0 min. The detection absorbance wavelength was set to 250 nm. The procedure was validated by Food and Drug Administration guidelines in terms of: system suitability, calibration range (0.05–5 mg/L), linearity, sensitivity, robustness, carry-over effect, specificity, accuracy (−11.1 to 4.2…
Analysis of basic drugs by liquid chromatography with environmentally friendly mobile phases in pharmaceutical formulations
2017
Abstract Basic drugs are positively charged in the usual working pH (2–8) in reversed-phase liquid chromatography. This gives rise to a strong association with the residual ionized silanols in conventional silica-based stationary phases, which is translated in poor peak shape and high consumption of organic solvent to get appropriate retention times. Micellar mobile phases containing surfactants give rise to modified stationary phases, where silanols are masked, improving the peak shape. However, mobile phases containing the anionic surfactant sodium dodecyl sulfate (SDS) require a small amount of organic solvent to conveniently decrease the retention of cationic analytes. An alternative is…
Construct Validity of Rizzo et al.'s (1970) Role Conflict and Ambiguity Scales: A Multisample Study
1998
La validite de construction des echelles de Rizzo, House, et Lirtzman (1970) a ete fortement critiquee ces dernieres annees. Les critiques portent sur la formulation des items qui constituent ces echelles, ce qui fait que l'interpretation des echelles depend totalement de la formulation des items. Ces critiques ont favorise l'emergence d'autres modeles factoriels. La duplication elargie de Kelloway et Barling (1990), l'analyse factorielle destinee a confirmer la validite des echelles de Rizzo et al. et une echelle de surcharge des roles avec des items formules a la fois affirmativement et negativement furent utilisees pour eprouver la validite de construction des echelles d'ambiguite et de …
Discriminant Validity of the Job-related Tension Scale
1993
L'Echelle de Tension Liee au Travail (JRTS) de Kahn et al. (1964) est l'une des echelles les plus usitees pour evaluer la tension professionnelle dans les etudes sur les correlats des conflits de roles et de l'ambiguite de role. Quelques auteurs ont suggere que cette echelle faisait appel aux concepts sous-jacents mesures par les echelles d'ambiguite et de conflits de roles (1970) de Rizzo, House, & Lirtzman (Jackson & Schuler, 1985). Dans cet article, la validite discriminante de la JRTS est mise factoriellement a l'epreuve
Spatiotemporal modeling and prediction of solar radiation
2003
[1] The radiation budget in the Earth-atmosphere system is what drives Earth's climate, and thus measurements of this balance are needed to improve our knowledge of Earth's climate and climate change. In the present paper we focus on the analysis of the surface shortwave radiation budget (SSRB), which is the amount of energy in the solar region of the electromagnetic spectrum (0.2–4.0 μm) absorbed at the surface. The SSRB has to be modeled from the surface to the top of the atmosphere, jointly with information about the state of the atmosphere and the surface. These data come from satellites orbiting the Earth and are often missing or disturbed. Its interest is not only at global scales; ra…
The role of the diagnostic areas in the assessment of landslide susceptibility models: a test in the sicilian chain
2011
Abstract The aim of the research was to verify and compare the predictive power of different diagnostic areas in assessing landslide susceptibility with a multivariate approach. Scarps, landslide areas (the union between scarp and accumulation zones) and areas uphill from crowns, for rotational slides, source or scarp areas and landslide areas, for flows, have been tested. A multivariate approach was applied to assess the landslide susceptibility on the basis of three selected conditioning factors (lithology, slope angle, and topographic wetness index), which were combined in a Unique Condition Unit (UCU) layer. By intersecting the UCU layer with the vector layer of the diagnostic areas, la…
Slope units-based flow susceptibility model: using validation tests to select controlling factors
2011
A susceptibility map for an area, which is representative in terms of both geologic setting and slope instability phenomena of large sectors of the Sicilian Apennines, was produced using slope units and a multiparametric univariate model. The study area, extending for approximately 90 km2, was partitioned into 774 slope units, whose expected landslide occurrence was estimated by averaging seven susceptibility values, determined for the selected controlling factors: lithology, mean slope gradient, stream power index at the foot, mean topographic wetness index and profile curvature, slope unit length, and altitude range. Each of the recognized 490 landslides was represented by its centroid po…
An evaluation of the estimation of road traffic emission factors from tracer studies
2010
Road traffic emission factors (EFs) are one of the main sources of uncertainties in emission inventories; it is necessary to develop methods to reduce these uncertainties to manage air quality more efficiently. Recently an alternative method has been proposed to estimate the EFs. In that work the emission factors were estimated from a long term tracer study developed in Ho Chi Minh City (HCMC) Vietnam. A passive tracer was continuously emitted from a finite line source placed in one side of an urban street canyon. Simultaneously, the resulting tracer concentrations were monitored at the other side of the street. The results of this experiment were used to calculate the dispersion factors an…
Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications
2019
[Abstract] BACKGROUND: Ectopic pregnancy is a life-threatening condition for which novel screening tools that would enable early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play an essential role in human reproduction, at least partially by regulating placental function and possibly embryo implantation. Kisspeptin levels are elevated massively in normal pregnancy and reportedly altered in various gestational pathologic diseases. Yet, the pathophysiologic role of KISS1/kisspeptin in ectopic pregnancy has not been investigated previously. OBJECTIVE: The purpose of this study was to evaluate changes of KISS1/kisspeptin levels in ectopic pregnancy and thei…