Search results for "VARY"

showing 10 items of 682 documents

Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet.

2003

BACKGROUND The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. METHODS Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. RESULTS In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a signific…

Adultmedicine.medical_specialtySaturated fatBody Mass Indexchemistry.chemical_compoundInsulin resistanceRisk FactorsInternal medicinemedicineHyperinsulinemiaHumansRisk factorTriglyceridesbusiness.industryCholesterolRehabilitationBody WeightCholesterol HDLFatty AcidsObstetrics and Gynecologymedicine.diseaseObesityPolycystic ovaryDietary FatsUnited StatesDietEndocrinologyReproductive MedicinechemistryItalyCardiovascular DiseasesFemaleInsulin ResistancebusinessBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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How should we manage atherogenic dyslipidemia in women with polycystic ovary syndrome?

2007

Despite their young age, women with polycystic ovary syndrome (PCOS) have increased cardiovascular risk. Besides normal concentrations of low-density lipoprotein (LDL) cholesterol, dyslipidemia is very common and includes elevated triglyceride levels and low high-density lipoprotein cholesterol concentrations. Recent findings also showed that women with PCOS have qualitative LDL alterations, with increased levels of atherogenic small, dense LDL particles. Such lipid abnormalities constitute a common form of dyslipidemia, the so-called atherogenic lipoprotein phenotype (ALP), associated with a greater cardiovascular risk. Weight reduction and increased physical activity may constitute first-…

Adultmedicine.medical_specialtySettore MED/09 - Medicina Interna10265 Clinic for Endocrinology and Diabetology610 Medicine & healthRisk AssessmentSeverity of Illness IndexSettore MED/13 - Endocrinologiachemistry.chemical_compoundWeight lossInternal medicinemedicineHumansatherosclerosis high-density lipoprotein cholesterol polycystic ovary syndrome small and dense low-density lipoprotein triglyceridesDyslipidemiasTriglyceridebusiness.industryCholesterolCholesterol HDLnutritional and metabolic diseasesObstetrics and Gynecology2729 Obstetrics and GynecologyCholesterol LDLmedicine.diseaseAtherosclerosisPrognosisPolycystic ovaryMetforminEndocrinologyTreatment OutcomechemistryCardiovascular Diseaseslipids (amino acids peptides and proteins)Drug Therapy CombinationFemaleControlled Clinical Trials as Topicmedicine.symptomHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessPioglitazoneDyslipidemiamedicine.drugLipoproteinPolycystic Ovary Syndrome
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Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome.

2009

OBJECTIVE: Dyslipidaemia is very common in patients with polycystic ovary syndrome (PCOS) but, beyond plasma lipids, atherogenic lipoprotein (Lp) and apolipoprotein (apo) alterations are still ill defined. DESIGN: We measured concentrations of apoB, Lp(a) and small, dense low-density lipoprotein (LDL) in 42 patients with PCOS [age: 28 +/- 7 years, body mass index (BMI): 27 +/- 5 kg/m(2)] vs. 37 age- and BMI-matched healthy controls. METHODS: Elevated Lp(a) levels considered were those > 30 mg/dl while elevated apoB concentrations were those > 100 g/l. RESULTS: Polycystic ovary syndrome showed increased triglycerides levels (p = 0.0011) and lower high-density lipoprotein (HDL)-cholesterol co…

Adultmedicine.medical_specialtySettore MED/09 - Medicina InternaApolipoprotein B10265 Clinic for Endocrinology and Diabetology610 Medicine & health2700 General MedicineSettore MED/13 - EndocrinologiaBody Mass Indexchemistry.chemical_compoundYoung AdultRisk FactorsInternal medicinemedicinedyslipidemia lipoproteins polycystic ovary syndromeHumansProspective cohort studyApolipoproteins BDyslipidemiasbiologyCholesterolbusiness.industryVascular diseaseCase-control studynutritional and metabolic diseasesGeneral MedicineCholesterol LDLmedicine.diseasePolycystic ovaryEndocrinologychemistry10036 Medical ClinicCardiovascular DiseasesCase-Control Studiesbiology.proteinlipids (amino acids peptides and proteins)FemalebusinessBody mass indexLipoproteinLipoprotein(a)Polycystic Ovary SyndromeInternational journal of clinical practice
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Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome.

2008

Abstract BACKGROUND: Dyslipidemia is a common metabolic complication in polycystic ovary syndrome (PCOS). The aim of this study was to determine if differences exist in dyslipidemia in women with PCOS from different ethnic and geographical backgrounds. METHODS: This retrospective study evaluated the serum fasting lipid profiles of 106 women with PCOS from the United States and 108 women with PCOS from Italy evaluated at endocrinology clinics. RESULTS: American women had higher mean body mass index than Italian women (36.1+/-8.6 vs 28.1+/-5.8 kg/m2, p<0.01). Low HDL-cholesterol was the most prevalent lipid abnormality in both populations. U.S. women had higher mean levels of serum total chol…

Adultmedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismEthnic groupPhysiologySettore MED/13 - EndocrinologiaBody Mass IndexCohort StudiesEndocrinologyRisk FactorsmedicinePrevalenceHumansObesityPCOS Hyperandrogenism Cardiovascular risk dyslipidemia LDL-cholesterolDyslipidemiasRetrospective StudiesGynecologybusiness.industryRetrospective cohort studyOverweightmedicine.diseaseObesityPolycystic ovarySettore MED/40 - Ginecologia E OstetriciaLipidsConfidence intervalUnited StatesItalyCardiovascular DiseasesFemalebusinessBody mass indexDyslipidemiaCohort studyPolycystic Ovary SyndromeJournal of endocrinological investigation
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Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients

2015

Abstract Objective We aim to assess the effect of metformin treatment on metabolic parameters, endothelial function and inflammatory markers in polycystic ovary syndrome (PCOS) subjects. Methods The study population consisted of 40 reproductive-age women with PCOS, who underwent treatment with metformin during a 12-week period, and their corresponding matched controls (n = 44). We evaluated endocrinological parameters, adhesion molecules (vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule 1 (ICAM-1) and E-selectin) and proinflammatory cytokines (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα)) in serum. In addition, interactions between human umbili…

Adultmedicine.medical_specialtyTime FactorsAdolescentendocrine system diseasesEndotheliumType 2 diabetesProinflammatory cytokineYoung AdultInsulin resistanceInternal medicineCell AdhesionHuman Umbilical Vein Endothelial CellsLeukocytesmedicineHumansLeukocyte RollingEndothelium Leukocyte Metformin Mitochondria PCOS Type 2 diabetesCells CulturedCell adhesion moleculebusiness.industryEndothelial Cellsnutritional and metabolic diseasesmedicine.diseasePolycystic ovaryCoculture TechniquesMetforminMetforminEndothelial stem cellTreatment Outcomemedicine.anatomical_structureEndocrinologyDiabetes Mellitus Type 2SpainCytokinesFemaleInflammation MediatorsCardiology and Cardiovascular MedicinebusinessCell Adhesion MoleculesBiomarkersPolycystic Ovary Syndromemedicine.drugAtherosclerosis
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Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance.

2011

Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function.We tested whether hyperandrogenic insulin-resistant women with PCOS, who have an increased risk of vascular disease, display impaired leukocyte-endothelium interactions, and mitochondrial dysfunction.This was a prospective controlled study conducted in an academic medical center.The study population consisted of 43 lean reproductive-age women with PCOS and 39 controls subjects.We evaluated anthropometric and metabolic parameters, adhesion molecules, and interactions between leukocytes and human umbilical vein endothelial cells. Mitochondrial function was studied by as…

Adultmedicine.medical_specialtyUmbilical VeinsAdolescentendocrine system diseasesNeutrophilsEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryVascular Cell Adhesion Molecule-1Cell SeparationBiologymedicine.disease_causeBiochemistrychemistry.chemical_compoundYoung AdultEndocrinologyInsulin resistanceOxygen ConsumptionInternal medicineE-selectinmedicineLeukocytesHumanschemistry.chemical_classificationReactive oxygen speciesInterleukin-6Tumor Necrosis Factor-alphaInsulinBiochemistry (medical)Endothelial Cellsnutritional and metabolic diseasesGlutathionemedicine.diseasePolycystic ovaryGlutathionefemale genital diseases and pregnancy complicationsMitochondriaEndothelial stem cellOxidative StressEndocrinologychemistrybiology.proteinFemaleInsulin ResistanceE-SelectinReactive Oxygen SpeciesOxidative stressPolycystic Ovary Syndrome
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Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of …

2013

Study question Is it possible to distinguish metabolically healthy polycystic ovary syndrome (MH-PCOS) from metabolically unhealthy PCOS (MU-PCOS) by simple diagnostic tools such as body mass index (BMI), waist/hip ratio (WHR), at-risk category suggested by Androgen Excess Society (AES) and visceral adiposity index (VAI)? Summary answer VAI could be an easy and useful tool in clinical practice and in population studies for assessment of MU-PCOS. What is known already VAI is a good indicator of insulin sensitivity and cardiometabolic risk in oligo-ovulatory women with PCOS. Study design, size, duration We conducted a cross-sectional study of 232 women with PCOS in a university hospital setti…

Adultmedicine.medical_specialtyWaistAdolescentPopulationSettore MED/13 - EndocrinologiaDiagnosis DifferentialInsulin resistanceRisk FactorsInternal medicinemedicinePCOSHumanseducationAdiposityeducation.field_of_studybusiness.industryRehabilitationnutritional and metabolic diseasesObstetrics and GynecologyOdds ratioGlucose Tolerance Testmedicine.diseasePolycystic ovaryConfidence intervalCross-Sectional StudiesPhenotypeReproductive MedicineFemaleMetabolic syndromeInsulin ResistancebusinessEnergy MetabolismBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study

2021

Abstract Aim We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women. Design. We conducted a randomized single-blind, pilot study. Methods Twenty-five obese women with polycystic ovary syndrome (PCOS) (33.7 ± 5.3 years, body mass index (BMI) 36.1 ± 3.9 kg/m2, mean ± SD) were randomized to semaglutide 1.0 mg or placebo for 16 weeks. We quantified tongue volume and its fat tissue and fat proportion by magnetic resonance imaging. Results Tongue fat tissue and fat proportion significantly reduced after semaglutide vs placebo (-1.94 ± 5.51 vs. + 3.12 ± 4.87 cm3, p = 0.022, and −0.02 ± 0.07 vs. 0.04 ± 0.06, p = 0.010, respectively). Correlation analysis rev…

Adultmedicine.medical_specialtyWaistEndocrinology Diabetes and MetabolismGlucagon-Like PeptidesAdipose tissuePilot ProjectsPlaceboGastroenterologyEndocrinologyDouble-Blind MethodTongueTongueInternal medicineInternal MedicinemedicineHumansSingle-Blind MethodObesityGlucagon like peptide-1 receptor Obesity PCOS Semaglutide Tongue fat Adult Double-Blind Method Female Glucagon-Like Peptides Humans Obesity Pilot Projects Single-Blind Method Adiposity TongueAdipositybusiness.industrySemaglutideGeneral Medicinemedicine.diseaseObesityPolycystic ovarymedicine.anatomical_structureFemalebusinessBody mass index
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Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in Southern Italy than in USA and the influence of criteria for the diagnosi…

2005

Objective: Metabolic syndrome (MBS) is a common disorder and is thought to be extremely prevalent in polycystic ovary syndrome (PCOS). In the USA the prevalence of MBS in PCOS has been reported to be as high as 43–46% using Adult Treatment Panel III (ATP-III) criteria. Because of differences in diet, lifestyle and genetic factors, we postulated that the prevalence of MBS might not be as high in Italian women. This study sought to determine the prevalence of MBS in Italian women using both the ATP-III and the World Health Organization (WHO) criteria and to determine whether the prevalence is influenced by the way in which PCOS is diagnosed. Design: Assessment of the prevalence of MBS in 282 …

Adultmedicine.medical_specialtyanimal structuresAdolescentEndocrinology Diabetes and MetabolismPopulationPrevalenceAnovulationEndocrinologyInsulin resistanceInternal medicinemedicinePrevalenceHumanseducationHypertriglyceridemiaeducation.field_of_studybusiness.industryPolycystic ovary syndrome (PCOS)HyperandrogenismGeneral Medicinemedicine.diseasePolycystic ovaryMetabolic syndromeUnited StatesEndocrinologyItalyFemaleMetabolic syndromebusinessPolycystic Ovary Syndrome
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Hyperinsulinism and polycystic ovary syndrome (PCOS): role of insulin clearance.

2015

PURPOSE: Insulin resistance and compensatory hyperinsulinism are the predominant metabolic defects in polycystic ovary syndrome (PCOS). However, hyperinsulinism, as well as being compensatory, can also express a condition of reduced insulin clearance. Our aim was to evaluate the differences in insulin action and metabolism between women with PCOS (with normal glucose tolerance) and age- and BMI-matched women with prediabetes (without hyperandrogenism and ovulatory disorders). METHODS: 22 women with PCOS and 21 age/BMI-matched women with prediabetes were subjected to a Hyperinsulinemic-euglycemic clamp and an Oral Glucose tolerance Test (OGTT). Insulin sensitivity was assessed by the glucose…

Adultmedicine.medical_specialtyendocrine system diseasesAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSettore MED/13 - EndocrinologiaPrediabetic StateYoung AdultEndocrinologyInsulin resistanceInternal medicineHyperinsulinismmedicineHumansInsulinPrediabetesbusiness.industryPolycystic ovary syndrome (PCOS)InsulinHyperandrogenismnutritional and metabolic diseasesGlucose clamp techniquemedicine.diseasePolycystic ovaryEndocrinologypolycystic ovary syndromeGlucose Clamp TechniqueFemaleInsulin ResistancebusinessHyperinsulinismPolycystic Ovary SyndromeJournal of endocrinological investigation
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