Search results for "VAST"
showing 10 items of 918 documents
Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-depende…
2022
Statins are primary drugs in the treatment of hyperlipidemias. This group of drugs is known for its beneficial pleiotropic effects (e.g., reduction of inflammatory state). However, a growing body of evidence suggests its diabetogenic properties. The culpable mechanism is not completely understood and might be related to the damage to pancreatic beta cells. Therefore, we conceived an in vitro study to explore the impact of atorvastatin on pancreatic islet beta cells line (1.1.E7). We evaluated the influence on viability, insulin, lowdensity lipoprotein (LDL) receptor, and proprotein convertase subtilisin/kexin type 9 (PCSK9) expression. A significant drop in mRNA for proinsulin and insulin e…
Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter.
2004
To test for intrinsic differences in metabolic properties of low-density lipoprotein (LDL) as a function of particle size, we examined the kinetic behavior of 6 human LDL fractions ranging in size from 251 to 265 A injected intravenously into human apolipoprotein (apo) B transgenic mice. A multicompartmental model was formulated and fitted to the data by standard nonlinear regression using the Simulation, Analysis and Modeling (SAAM II) program. Smaller sized LDL particles (251 to 257 A) demonstrated a significantly slower fractional catabolic rate (FCR) (0.050 +/- 0.045 h(-1)) compared with particles of larger size (262 to 265 A) (0.134 +/- -0.015 h(-1), P.03), and there was a significant …
Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activatio…
1999
To test the Kirsten-Ras (Ki-Ras) alternative prenylation hypothesis in malignant transformation, we used a novel farnesyltransferase inhibitor competitive to farnesyl-pyrophosphate, RPR130401, and a CaaX peptidomimetic geranylgeranyltransferase-1 inhibitor GGTI-298. In Ki-Ras-overexpressing transformed adrenocortical cells, RPR130401 at 1-10 microM inhibited very efficiently the [(3)H]farnesyl but not [(3)H]geranylgeranyl transfer to Ras. However, proliferation of these cells was only slightly sensitive to RPR130401 (IC(50)=30 microM). GGTI-298 inhibited the growth of these cells with an IC(50) of 11 microM but cell lysis was observed at 15 microM. The combination of 10 microM RPR130401 and…
Giorgio Vasta, Spaesamento
2012
Si tratta di una recensione multimediale dedicata al romanzo di Giorgio Vasta intitolato "Spaesamento"
The roles of the state and social licence to operate? Lessons from nuclear waste management in Finland, France, and Sweden
2019
The concept of social licence to operate (SLO) is an increasingly popular tool for companies to manage their relations with the local communities. SLO is very seldom used in the nuclear sector, which has nevertheless applied similar approaches, under notions such as partnership and participatory governance. This article explores the specific challenges that the application of SLO faces in the nuclear waste management (NWM) sector, by applying an often-used SLO framework of Boutilier and Thomson to illustrative case studies concerning nuclear waste repository projects in Finland, France and Sweden. Among the specificities of this sector, the article focuses on the central roles of the state …
Asociación de pravastatina y fenofibrato (Pravafenix®). Estudios de seguridad
2014
Resumen Aunque el colesterol unido a lipoproteinas de baja densidad (cLDL) es el objetivo primario de tratamiento para reducir el riesgo cardiovascular, el incremento de trigliceridos y el descenso del colesterol unido a lipoproteinas de alta densidad (cHDL) constituyen el denominado riesgo cardiovascular residual. El tratamiento con estatinas asociado a fibratos es una posibilidad real de tratamiento del riesgo cardiovascular total. Sin embargo, esta asociacion puede con frecuencia asociarse a efectos adversos, especialmente musculares y hepaticos. Por sus caracteristicas farmacologicas, la asociacion de pravastatina con fenofibrato puede ser eficaz y segura, con escasos efectos secundario…
Vaakakupissa vaarat ja vastuu: Julkisen palvelun median arvot sosiaalisen median alustojen paineessa
2021
Sosiaalisen median alustat ovat muovanneet media-alan prosesseja ja käytäntöjä merkittävästi. Alustayritysten toimintaa ohjaavat erilaiset arvot ja tavoitteet kuin mediaorganisaatioita, mikä aiheuttaa toimijoiden välille ristiriitaa. Toimintatavoistaan ja arvoistaan sosiaalisessa mediassa joutuvat neuvottelemaan erityisesti julkisen palvelun mediayhtiöt, joiden peruskivenä ovat julkisen palvelun arvot. Tarkastelemme tässä artikkelissa suomalaisen julkisen palvelun mediayhtiön Yleisradion alustasuhdetta laadullisen haastatteluaineiston avulla. Kysymme, miten Yleisradiossa kuvataan ja perustellaan suhdetta sosiaalisen median alustoihin ja minkälaiseen arvopuheeseen suhteen kuvaaminen kytkeyty…
Hellisonin vastuuntuntoisuuden mallin kokeilu seitsemännen luokan poikien liikuntatunneilla
2002
Vastuuntuntoisuuteen kasvattaminen liikunnanopetuksen avulla : Hellisonin vastuuntuntoisuuden mallin ja Kohlbergin moraalikehityksen teorian näkökulma
2007
Exploring global responsibility in higher education students’ cross-cultural dialogues
2019
This study engages with current debate around global education and internationalization of higher education(HE). There is an identified need to critically reflect on how global education commitments are introduced to HE students, and how the debates are brought to individual as well as institutional levels. The study explores how students in a Finnish university develop their understanding of global education, citizenship and potential dispositions towards global responsibility. The students participated in an international seminar on the global Education for All (EFA) process, with purposefully planned participatory activities and cross-cultural dialogues, and reflected on their learning a…