Search results for "VAST"

A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Tre…

2020

Abstract Despite huge progress in hormonal therapy and improved in vitro fertilization methods, the success rates in infertility treatment are still limited. A recently discovered mechanism revealed the interplay between the plasma protein fetuin‐B and the cortical granule‐based proteinase ovastacin to be a novel key mechanism in the regulation of fertilization. Upon sperm–egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and eventually provides a definitive block against polyspermy. An untimely onset of this zona hardening prior to fertilization would consequently result in infertility. Physiologically, this proc…

Seikkailija Paul Moij : Viipurin valta- ja vastakulttuurit 1600-luvun jälkipuoliskolla

2017

A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION

2007

The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.

Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patien…

2015

OBJECTIVE: To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053).METHODS: Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); add-on ezetimibe 10 mg/day; or double-dose rosuvastatin. Patients had cardiovascular disease (CVD) and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL (1.8 mmol/L) or CVD risk factors and LDL-C ≥100 mg/dL (2.6 mmol/L). In the alirocumab group, dose was blindly increased at Week 12 to 150 mg Q2W (also 1-mL volume) in patients not achieving their LDL-C target. Primary endpoi…

Comparison of force-velocity relationships of vastus lateralis muscle in isokinetic and in stretch-shortening cycle exercises

2003

Aim:  This study investigated the force–velocity characteristics of the vastus lateralis (VL) muscle fascicle and muscle–tendon unit (MTU) in isolated lengthening and shortening actions, and during natural movement. Methods:  Four subjects performed maximal eccentric and concentric knee extensions (60, 120 and 180° s−1). Unilateral counter movement jumps and drop jumps in the sledge apparatus served as natural movements. Vastus lateralis fascicle lengths were determined from ultrasonography. In vivo patellar tendon forces (PTF) were measured with an optic fibre technique. Patellar tendon force was derived to VL force according to the cross-sectional area of the muscle. Force in the directio…

Muscle-Tendon Interaction During Human Dolphin-Kick Swimming

2019

Without high impact forces, it is not clear how humans can utilize tendon elasticity during low-impact activities. The purpose of the present study was to examine the muscle-tendon behavior together with the electromyographic (EMG) activities of the vastus lateralis (VL) muscle during the human dolphin-kicking. In a swimming pool, each subject (n = 11) swam the 25 m dolphin-kicking at two different speeds (NORMAL and FAST). Surface EMGs were recorded from the VL and biceps femoris (BF) muscles. Simultaneous recordings of the knee joint angle by electro-goniometer and of the VL fascicle length by ultrasonography were used to calculate the muscle-tendon unit and tendinous length of VL (LMTU a…

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

2021

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

Epäkerrottu ja vastakerronta Ben Lernerin romaanissa 10:04

2017

Tutkielman tavoitteena on analysoida henkilökertojan sisäisen maailman esittämistä yhdysvaltalaisen Ben Lernerin romaanissa 10:04 (2014) Gerald Princen epäkerrotun (engl. disnarrated) ja Brian Richardsonin vastakerronnan (engl. denarration) käsitteiden pohjalta. Narratologiassa epäkerrotun käsitteellä tarkoitetaan sellaisia kerrottuja tapahtumia, jotka eivät toteudu kertomuksen tarinamaailmassa, mutta ovat siellä kuitenkin mahdollisia. Vastakerronnalla viitataan puolestaan kerronnan tilanteisiin, joissa kiistetään tai perutaan kertomuksen elementtejä, jotka on siihen asti esitetty tarinamaailmaan kuuluvina. Tässä tutkielmassa epäkerrottua ja vastakerrontaa käsitellään erityisesti henkilöker…

Short-term atorvastatin treatment does not modify neointimal morphology but reduces MMP-2 expression in normocholesterolemic rabbit stented arteries.

2006

The aim of our study was to explore some potential pleiotropic effects of atorvastatin, after stenting in the iliac arteries of normocholesterolemic rabbits. On day 0, 27 rabbits underwent stent implantation and were randomized into either the control group (standard chow, CTRL, n = 15) or the atorvastatin group (10 mg/kg/d per os, Ator, n = 12). On day 30, the stented arteries were harvested for histomorphometry and neointimal analysis [macrophages, matrix metalloproteinases (MMP-2), tissue inhibitor of metalloproteinase-2, vascular smooth muscle cells, and collagen]. Atorvastatin did not induce significant histomorphometric and inflammatory modifications but reduced neointimal expression …

Proscribing the Nordic Resistance Movement in Finland: Analyzing the Process and its Outcome

2021

The Nordic Resistance Movement (NRM) was banned in Finland in 2020 after a court process lasting more than two and half years. This article details how effective the ban has been and how the organization has adapted to the ban, both during the process and after the verdict. The NRM has followed strategies similar to previous proscription cases, especially National Action in the UK in 2016, with whom NRM members discussed and shared experiences before the banning process began. Adaptation has meant new organizational forms and the founding of new associations. Before the ban, some commentators argued that it would only radicalize NRM members and that they might move to clandestine actions. B…