Search results for "VELOCITY"
showing 10 items of 881 documents
Efficacy of dulaglutide on vascular health indexes in subjects with type 2 diabetes: a randomized trial
2021
Abstract Background Recent cardiovascular outcome trials have shown significant reductions in major cardiovascular (CV) events with glucagon-like peptide (GLP)-1 receptor agonists. Additionally, adjunctive surrogates for cardiovascular risk validated by some studies include arterial stiffness and endothelial function indexes. To date, no randomized trial has addressed the possible effects of antidiabetic interventional drugs such as GLP1 agonists on endothelial and arterial stiffness indexes as surrogate markers of vascular damage. Aims We aimed to evaluate metabolic efficacy and surrogate vascular efficacy endpoints of once-weekly dulaglutide (1.5 mg) plus traditional antidiabetic treatmen…
Platelet-endothelial interaction in tumor angiogenesis and microcirculation
2003
Activated platelets release angiogenic growth factors and have therefore been proposed to contribute to tumor angiogenesis within a potentially prothrombotic tumor microcirculation. The aim of the study was to investigate interactions of platelets with the angiogenic microvascular endothelium of highly vascularized solid tumors during growth and in response to endothelial stimulation in comparison with normal subcutaneous tissue. Experiments were performed in the dorsal skinfold chamber preparation of C57BL/6J mice bearing the Lewis lung carcinoma (LLC-1) or methylcholanthrene-induced fibrosarcoma (BFS-1). Fluorescently labeled rolling and adherent platelets, red blood cell velocity, and ve…
Modelling and Simulation of Gas–liquid Hydrodynamics in a Rectangular Air-lift Reactor
2013
Abstract Computational Fluid Dynamics is a quite well established tool for carrying out realistic simulations of process apparatuses. However, as a difference from single phase systems, for multiphase systems the development of CFD models is still in progress. Among the two-phase systems, gas–liquid systems are characterised by an additional complexity level, related to the fact that bubble sizes are not known in advance, being rather the result of formation and breakage-coalescence dynamics and therefore of complex phenomena related to flow dynamics and interfacial effects. In the present work, Euler–Euler Reynolds-averaged flow simulations of an air-lift reactor are reported. All bubbles …
Revealing the structure of the lensed quasar Q 0957+561. I. Accretion disk size
2021
We thank the anonymous referee for the helpful comments, and constructive remarks on this manuscript. We thank the GLENDAMA project for making publicly available the monitoring data of Q 0957+561. C.F. gratefully acknowledges the financial support from Tel Aviv University and University of Haifa through a DFG grant HA3555-14/1. E.M. and J.A.M are supported by the Spanish MINECO with the grants AYA2016- 79104-C3-1-P and AYA2016-79104-C3-3-P. J.A.M. is also supported from the Generalitat Valenciana project of excellence Prometeo/2020/085. J.J.V. is supported by the project AYA2017-84897-P financed by the Spanish Ministerio de Economia y Competividad and by the Fondo Europeo de Desarrollo Regi…
Fracture and Fatigue of Travelling Plates
2013
In this chapter, problems of fracture and stability of a moving plate, travelling in a system of rollers at a constant velocity, are studied. It is known that in the manufacturing process, there may occur many kinds of defects in the paper web, such as edge cracks and blister and fiber cuts. Our aim is to tackle this problem and analyse theoretically how the defects change the behaviour. We will use the model of a thin elastic plate made of brittle material. A plate with initial cracks is studied, subjected to constant tension and cyclic tension. As a result, we will show how to find safe parameter ranges of transport velocities and in-plane tensions when fracture, stability and constraints…
The automated assesment of artery hemodynamic parameters from ultrasound video
2012
The custom designed video processing software for analysis of B-mode and Doppler-mode ultrasound video has been proposed in this work. The software allows adjusting user-defined thresholds and tolerance levels to enhance contour detection in noisy and artifacted ultrasound images. The developed software is able to evaluate 16 hemodynamic parameters (artery diameter, pulse rate and flow velocity related parameters) in each cardiac cycle. The measurements were performed intermittently recording artery diameter (B-mode) and flow velocity (Doppler-mode). Software has validated in femoral artery measurements. The hemodynamic parameters computed by software were consistent with those obtained by …
Cardiac output following fetoscopic coagulation of major placental vessels in fetal sheep.
2008
Objectives To measure changes in cardiac output (CO) after partial cord occlusion in fetal sheep in order to investigate pathophysiological fetal adaptation mechanisms in a simulated acute placental insufficiency model under standardized conditions, with the aim of finding relevant methods for monitoring human fetuses during stress situations. Methods We used minimally invasive, percutaneous endoscopic techniques to close umbilical vessels in mid-gestational fetal sheep. Placental blood flow was reduced by preferentially closing first arterial and then the concomitant venous umbilical vessels within a short time interval. The investigations were carried out on 11 pregnant ewes at a median g…
[Diagnosis of coronary microvascualar dysfunction in diabetic patients with cardiac syndrome X: comparison by current methods].
2013
The study population included 208 patients with chest pain and uninjured coronary arteries that we split into two populations: diabetics (72 patients) and non-diabetics (136 patients). We split patients with chest pain and uninjured coronary arteries that had a myocardial scintigraphy into two populations: patients with positive scintigraphy and negative. We calculated, on angiographic images of each patient, stored on suitable digital supports, Timi Frame Count (TFC), Myocardial Blush Grade (MBG) and Total Myocardial Blush Score (TMBS) using the protocol described by Gibson and Yusuf. On the basis of Yusuf's experience we imagined a new index: the Total Timi Frame Count as the sum of the t…
Relationship Between Carotid Atherosclerosis and Pulse Pressure with Renal Hemodynamics in Hypertensive Patients.
2015
BACKGROUND Structural atherosclerotic damage, arterial stiffness, pulse pressure (PP), and renal hemodynamics may interact and influence each other. Renal resistance index (RRI) appears as a good indicator of systemic vascular changes. The aim of our study was to assess the independent relationships of carotid intima-media thickness (cIMT), aortic pulse wave velocity (aPWV), and peripheral PP with RRI in hypertensives with various degrees of renal function. METHODS We enrolled 463 hypertensive patients (30-70 years) with normal renal function (group 0; n = 280) and with chronic kidney disease (groups I-V; n = 183). All subjects underwent ultrasonographic examination of intrarenal and caroti…
Early Vascular Aging in Normotensive Patients With Systemic Lupus Erythematosus
2015
Connective tissue diseases, like systemic lupus erythematosus (SLE), are associated with early and accelerated atherosclerosis. Recently, the concept of “early vascular aging” (EVA) has been more widely accepted. Aortic stiffness is one of the important markers of EVA. We evaluated EVA and subclinical atherosclerosis, by measuring aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), in 50 normotensive patients with SLE (mean age: 39 ± 12 years). We compared these participants with 50 age- and sex-matched patients with essential hypertension (EH) and 20 healthy controls. Each participant underwent 24-hour ambulatory blood pressure monitoring (ABPM), aPWV, and cIMT me…