Search results for "VIEWS"
showing 10 items of 576 documents
Targeting B cells in relapsing–remitting multiple sclerosis: from pathophysiology to optimal clinical management
2017
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an autoimmune response against central nervous system (CNS) structures. Traditionally considered a T-cell-mediated disorder, the contribution of B cells to the pathogenesis of MS has long been debated. Based on recent promising clinical results from CD20-depleting strategies by three therapeutic monoclonal antibodies in clinical phase II and III trials (rituximab, ocrelizumab and ofatumumab), targeting B cells in MS is currently attracting growing interest among basic researchers and clinicians. Many questions about the role of B and plasma cells in MS remain still unanswered, ranging from the role of…
Update and guidance on management of myopia : European Society of Ophthalmology in cooperation with International Myopia Institute
2021
The prevalence of myopia is increasing extensively worldwide. The number of people with myopia in 2020 is predicted to be 2.6 billion globally, which is expected to rise up to 4.9 billion by 2050, unless preventive actions and interventions are taken. The number of individuals with high myopia is also increasing substantially and pathological myopia is predicted to become the most common cause of irreversible vision impairment and blindness worldwide and also in Europe. These prevalence estimates indicate the importance of reducing the burden of myopia by means of myopia control interventions to prevent myopia onset and to slow down myopia progression. Due to the urgency of the situation, t…
Experimental and human population studies of DNA lesions in healthy individuals
2017
DNA damage is a valuable biomarker in human molecular epidemiology being associated with many diseases. However, the level of DNA damage is influenced also by intrinsic features of healthy individuals: heredity, sex, age and body type. This review summarizes data on DNA breakage level in healthy humans depending on their characteristics and compares these data with experimental studies and observations on animals. Several strains of laboratory animals manifest an increased level of DNA breaks. In humans, some gene polymorphisms are associated with an increased level of DNA damage; however it is believed that environmental factors are more important. In animals, a higher level of DNA breakag…
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with the…
2020
Despite the progress in perinatal care, perinatal asphyxia (PA) remains a significant problem in neonatology. The development of therapeutic hypothermia (TH) has improved the prognosis, but it still remains uncertain in hypoxic neonates. The evaluation of the severity of ischemia/hypoxia after birth is crucial to the choice of treatment, and with accurate long-term prognosis, appropriate further patient care can be planned. This article presents various methods for the preliminary assessment of brain damage and prognosis in newborns with PA treated with TH. The importance of assessing the neurological condition and the usefulness of laboratory and electrophysiological testing and imaging ar…
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
2006
SUMMARY Two-component signal-transducing systems are ubiquitously distributed communication interfaces in bacteria. They consist of a histidine kinase that senses a specific environmental stimulus and a cognate response regulator that mediates the cellular response, mostly through differential expression of target genes. Histidine kinases are typically transmembrane proteins harboring at least two domains: an input (or sensor) domain and a cytoplasmic transmitter (or kinase) domain. They can be identified and classified by virtue of their conserved cytoplasmic kinase domains. In contrast, the sensor domains are highly variable, reflecting the plethora of different signals and modes of sens…
Narratives of Burnout and Recovery from an Agency Perspective : A Two-Year Longitudinal Study
2017
Abstract Purpose To provide knowledge about the recovery process during rehabilitation and two years later by exploring the manifestation of agency and spheres of meaning in the narratives of participants in a national rehabilitation course. Material and methods The subjects of the study were four participants in a national rehabilitation course, whose burnout levels had decreased between the initial and follow-up periods of the course. Semi-structured interviews on two occasions and an electronic questionnaire 1.5 years post rehabilitation comprised the main material. In addition, the BBI -15 (Bergen Burnout Indicator) and DEPS-screen were used. Results Thematic narrative analysis revealed…
Standardized on-road tests assessing fitness-to-drive in people with cognitive impairments: A systematic review.
2020
Objective The on-road assessment is the gold standard because of its ecological validity. Yet existing instruments are heterogeneous and little is known about their psychometric properties. This study identified existing on-road assessment instruments and extracted data on psychometric properties and usability in clinical settings. Method A systematic review identified studies evaluating standardized on-road evaluation instruments adapted for people with cognitive impairment. Published articles were searched on PubMed, CINHAL, PsycINFO, Web of Science, and ScienceDirect. Study quality and the level of evidence were assessed using the COSMIN checklist. The collected data were synthetized usi…
On the participatory agency of texts: Using institutional forms in performance appraisal interviews
2020
Abstract Drawing on studies of the performative effects and agency of texts in organizations, the paper investigates how the agency of texts figures through their participatory status in interaction. The empirical data for the study consist of video-recorded performance appraisal interviews in a Finnish public organization in which the interaction relies heavily on an appraisal form. The data are analyzed through a sequential analysis that draws on multimodal conversation analysis and ethnographic knowledge. The analysis shows that the human participants orient to three different acts that are inscribed in the textual document: 1) presenting demands for the participants; 2) offering topics …
Homescape
2020
Abstract This article presents the redefined concept of the homescape as space where transnational, newly arrived, and settled families can provide agency for their identity framing through multisensory discourse resources. The study investigated the experiential, non-interactional multisensory discourse resources in the homescape. The homescape extends from the Linguistic Landscape and houses temporal and spatial components, which occur over time. The yearlong ethnographic case study of three Nepalese families (two transmigrant Ghurkha families and one immigrant family) included 150 hours of observational data triangulated with qualitative interviews. The study posed two questions: How do …
Prevalence os sending, receiving and forwarding sexts among youths: A three-level meta-analysis.
2020
Alttes ajuts: Conselleria d'Educació, Investigació, Cultura i Esport DOGV No. 7943, ACIF, 837 2017 By systematic review with a three-level, mixed-effects meta-analysis, this paper examines the prevalence of sexting experiences among youths aimed at analyzing conceptual and methodological moderators that might explain its heterogeneity. A search was conducted of five bibliographic databases and grey literature up until February 2020. The risk of bias in primary studies was assessed. A total of seventy-nine articles met the set inclusion criteria. Mean prevalences for sending, receiving and forwarding sexts were.14 (95% CI:.12,.17),.31 (95% CI:.26,.36) and.07 (95% CI:.05,.09), respectively, e…