Search results for "VIH-1"
showing 3 items of 3 documents
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
2015
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations…
Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (C…
2019
Background and aims Limited data are available on the effectiveness and tolerability of direct-acting antivirals (DAAs) therapies in the real world for HCV-infected patients with comorbidities. This study aimed to describe the effectiveness of OBV/PTV/r +/- DSV (3D/2D regimen) with or without ribavirin (RBV) in HCV or HCV/HIV co-infected patients with GT1/GT4 and CKD (IIIb-V stages), including those under hemodialysis and peritoneal dialysis in routine clinical practice in Spain in 2015. Material and methods Non-interventional, retrospective, multicenter data collection study in 31 Spanish sites. Socio-demographic, clinical variables, study treatment characteristics, effectiveness and toler…
Evolución de la resistencia transmitida y adquirida a fármacos antirretrovirales en pacientes infectados con VIH-1
2018
Introducción: La adquisición y transmisión de resistencia amenaza el éxito del tratamiento antirretroviral. En este estudio evaluamos el comportamiento epidemiológico de las mutaciones de resistencia (MR) a fármacos antirretrovirales del VIH-1 según factores de riesgo y clínicos específicos. Metodología: Este es un estudio retrospectivo observacional de series transversales acumuladas, realizado en la Unidad de Enfermedades Infecciosas de un hospital universitario en España (CHGUV) entre los años 2003 y 2014. Nuestro objetivo fue estimar la evolución de la frecuencia anual de MR a fármacos antirretrovirales en el genoma de la proteasa y transcriptasa inversa del VIH-1 durante el periodo de …