Search results for "VISCOSITY"
showing 10 items of 542 documents
Full band spectroscopic studies on the molecular mobility of diluted alcohols
1991
Abstract Static permittivity has been determinded for pure n-decanol and cyclohexanol and their solutions in cyclohexane up to very dilute solutions, the dipole moment is found to decrease with the increase in concentration to a minimum, then it increases continuously. At a certain concentration range, no effect of temperature on the measured dipole moments could be observed, within the observed temperature interval. The dielectric loss was measured in the frequency range from o.1 GHz to 670 GHz. The data are analysed in several Debye and Frohlich terms and the results are discussed.
Molecular interactions in 1-pentanol +2-methyl-2-butanol mixtures: Static dielectric constant, viscosity and refractive index investigations at 5, 25…
1989
Static dielectric constants, refractive indices and viscosities of 1-pentanol +2-methyl-2-butanol mixtures were measured at 5, 25 and 45°C. The results show that the mixing of the two isomers modifies the polarizability and the resistence of viscous flow of the system depending on the composition and temperature. Short range intermolecular interactions producing hetero-alcohol open dimers are considered.
Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristi…
2015
ABSTRACT: Disintegration of oral solid dosage forms is a prerequisite for drug dissolution and absorption and is to a large extent dependent on the pressures and hydrodynamic conditions in the solution that the dosage form is exposed to. In this work, the hydrodynamics in the PhEur/USP disintegration tester were investigated using computational fluid dynamics (CFD). Particle image velocimetry was used to validate the CFD predictions. The CFD simulations were performed with different Newtonian and non-Newtonian fluids, representing fasted and fed states. The results indicate that the current design and operating conditions of the disintegration test device, given by the pharmacopoeias, are n…
Influence of poloxamers on the dissolution performance and stability of controlled-release formulations containing Precirol® ATO 5
2005
Abstract Lipid excipients are usually used for the development of sustained-release formulations. When used in relatively high quantities, Precirol ® ATO 5 imparts sustained-release properties to solid oral dosage forms, by forming a lipid matrix. To control or adjust the drug release kinetics from such lipid matrix however, one must often resort to complementary ingredients or techniques. This study investigates the influence of poloxamers (Lutrol ® ) included in lipid matrices composed of glyceryl palmitostearate (Precirol ® ATO 5) on their dissolution performance and their stability. The addition of these hydrophilic polymers in the lipid matrix increased the amount of theophylline relea…
Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity
2012
A negative food effect, i.e. a decrease in bioavailability upon the co-administration of compounds together with food, has been attributed particularly with high solubility/low permeability compounds (BCS class III). Different mechanisms have been proposed including intestinal dilution leading to a lower concentration gradient across the intestinal wall as well as binding of the active pharmaceutical ingredient to food components in the intestine and thereby decreasing the fraction of the dose available for absorption. These mechanisms refer primarily to the compound and not to the dosage form. An increase in viscosity of the dissolution fluid will in particular affect the absorption of BCS…
Molekülgrößenbestimmungen an makromolekularen Stoffen (Kritik und Vergleich der Methoden)
1952
A survey is given of the most important methods for determination of molecular weight (osmotic pressure, ultracentrifuge and diffusion, light scattering, viscosity). All the methods require an extrapolation to zero concentration in order to use equations valid for ideal solutions. Furthermore the polymolecularity of the examined substance must be considered, since each method yields a characteristic average of molecular weight differing from the others. The present limits of the methods are given and their results compared.
Hemorheologic profile of hyperlipidemic patients treated with gemfibrozil
1996
Abstract We measured the plasma lipid levels and the macrorheologic (whole-blood, plasma, and serum viscosity levels; fibrinogen; hematocrit; mean erythrocyte aggregation; and whole-blood filterability) and microrheologic (erythrocyte membrane fluidity and red cell membrane protein lateral mobility) determinants in a group of 19 hyperlipidemic patients (Fredrickson's classification phenotype IIa, 12 patients; phenotype IV, 4; phenotype IIb, 3) at baseline and after 45 and 90 days of treatment with gemfibrozil (900 mg orally once a day). At baseline we noted statistically significant increases in plasma viscosity level, fibrinogen, and mean erythrocyte aggregation, as well as a statistically…
Phase transitions in a colloidal dispersion flowing through a cylindrical capillary
2008
The flow of a charged-stabilized colloidal dispersion of crystalline equilibrium structure through a cylindrical capillary is investigated. The simultaneous existence of up to three differently ordered states is observed under conditions of stationary flow. The evolution of their concentric arrangement along the capillary is determined by Bragg microscopy. For sufficient low fluxes, stationary phase distributions are obtained. While the apparent viscosity is non-monotonous and non-Newtonian, the corresponding velocity profiles are found to be piecewise parabolic and are compatible to numerical calculations. Furthermore, we test the assumption of a constant yield stress determining the radia…
Temperature dependence of η/s of strongly interacting matter: Effects of the equation of state and the parametric form of (η/s)(T)
2020
We investigate the temperature dependence of the shear viscosity to entropy density ratio $\ensuremath{\eta}/s$ using a piecewise linear parametrization. To determine the optimal values of the parameters and the associated uncertainties, we perform a global Bayesian model-to-data comparison on $\mathrm{Au}+\mathrm{Au}$ collisions at $\sqrt{{s}_{\mathrm{NN}}}=200$ GeV and $\mathrm{Pb}+\mathrm{Pb}$ collisions at 2.76 TeV and 5.02 TeV, using a $2+1\mathrm{D}$ hydrodynamical model with the Eskola-Kajantie-Ruuskanen-Tuominen (EKRT) initial state. We provide three new parametrizations of the equation of state (EoS) based on contemporary lattice results and hadron resonance gas, and use them and t…
Sound absorption prediction of linear damped acoustic resonators using a lightweight hybrid model
2019
International audience; A lightweight numerical method is developed to predict the sound absorption coefficient of resonators whose cross-section dimensions are significantly larger compared to the viscous and thermal boundary layer’s thicknesses. This method is based on the boundary layer theory and on the perturbations theory. According to the perturbations theory, in acoustical domains with large dimensions, the fluid viscosity and thermal conductivity only affect the boundary layers. The model proposed in this article combines the lossless Helmholtz wave equation derived from a perfect fluid hypothesis, with viscosity and thermal conductivity values of a real fluid to compute the sound …