Search results for "VOD"

Urine tropenol ester levels in workers handling tiotropium bromide synthesis: implications for exposure prevention and biomonitoring

2019

Tropenol ester is a highly toxic anticholinergic substance and an intermediate used in industrial production of the bronchodilator tiotropium bromide. The aim of this study was to systematically test workers involved in its production for tropenol ester in urine to identify any exposure pathways and define additional preventive measures. Twelve workers performing tasks involving potential exposure to tropenol ester were repeatedly monitored at the end of each production cycle. Medical exams revealed no symptoms of acute poisoning with tropenol ester, but biological monitoring of urine showed 36 positive findings in 79 samples, with tropenol ester concentrations ranging between the detection…

Effects of post-extinction l-DOPA administration on the spontaneous recovery and reinstatement of fear in a human fMRI study

2015

Relapse is a pertinent problem in the treatment of anxiety disorders. In the laboratory, relapse is modeled as return of conditioned fear responses after successful fear extinction and is explained by insufficient retrieval and/or expression of the fear-inhibitory extinction memory that is generated during extinction learning. We have shown in mice and humans that return of fear can be prevented by administration of a single dose of the dopamine precursor l-3,4-dihydroxyphenylalanine (l-DOPA) immediately after extinction. In mice, this effect could be attributed to an enhancement of extinction memory consolidation. In our human study, we could not exclude that l-DOPA might have acted by int…

Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Methods Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT scor…

Thrombocytopenia Associated With Levodopa Treatment

2003

Anthropology of Political, Social and Cultural Memory: Practices in Central and Eastern Europe: Program & Abstracts : International Scientific Confer…

2020

L-Band vegetation optical depth for crop phenology monitoring and crop yield assessment

2018

Vegetation Optical Depth (VOD) at L-band is highly sensitive to the water content and above-ground biomass of vegetation. Hence, it has great potential for monitoring crop phenology and for providing crop yield forecasts. Recently, the Multi-Temporal Dual Channel Algorithm (MT -DCA) has been proposed to retrieve L-band VOD from Soil Moisture Active Passive (SMAP) measurements. In previous research, SMAP VOD has been compared to crop phenology and has been used to derive crop yield estimates. Here, we review and expand these initial research studies. In particular, we quantify the capability of VOD to detect different crop stages, and test different VOD metrics (i.e., maximum, range and inte…

Les chansons de Boris Vian en bande dessinée

2021

espanolBoris Vian se dedico a la cancion a partir de los anos 50 para manifestar, con total libertad de expresion y siempre con un toque de humor desacralizante, su pasion por la musica. El enfoque elegido para este estudio sera el de considerar la adaptacion al comic de las letras de algunas canciones de Vian. Una labor de transposicion inventiva realizada por autores reconocidos del noveno arte como Etienne Davodeau o David Prudhomme. Se trata de un estudio intermediatico en el que la musica se vincula al dibujo y se analizan los mecanismos elegidos de concordancia de estilos y tratamientos que unen el grafismo con el ritmo musical y el uso particular del lenguaje en las letras de Vian. E…

Structural, vibrational and electrical study of compressed BiTeBr

2016

Compresed BiTeBr has been studied from a joint experimental and theoretical perspective. Room-temperature x-ray diffraction, Raman scattering, and transport measurements at high pressures have been performed in this layered semiconductor and interpreted with the help of ab initio calculations. A reversible first-order phase transition has been observed above 6–7 GPa, but changes in structural, vibrational, and electrical properties have also been noted near 2 GPa. Structural and vibrational changes are likely due to the hardening of interlayer forces rather than to a second-order isostructural phase transition while electrical changes are mainly attributed to changes in the electron mobilit…

Functional feature of a novel model of blood brain barrier: Studies on permeation of test compounds

2001

Drug delivery to the central nervous system (CNS) is subject to the permeability limitations imposed by the blood-brain barrier (BBB). Several systems in vitro have been described to reproduce the physical and biochemical behavior of intact BBB, most of which lack the feature of the in vivo barrier. We developed a fully formed monolayer of RBE4.B immortalized rat brain microvessel endothelial cells (ECs), grown on top of polycarbonate filter inserts with cortical neuronal cells grown on the outside. Neurons induce ECs to synthesize and sort occludin to the cell periphery. Occludin localization is regulated by both compositions of the substratum and soluble signals released by cortical co-cu…

Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue

2016

Levodopa (l-DOPA) is the most effective pharmacologic agent in Parkinson's disease and remains the "gold standard". Nevertheless, in long-term treatments, dyskinesias and motor complications can emerge. In this work, the combined use of l-DOPA methylester hydrochloride prodrug (LDME) with transbuccal drug delivery was supposed as a good alternative method to optimize the bioavailability of l-DOPA, to maintain constant plasma levels and to decrease the drug unwanted effects. The effects of environmental pH on buccal delivery of LDME were evaluated ex vivo. The increase of pH value from 5.8 to 6.2 implies an improvement of drug permeation. Since the pH increase causes the raising of hydrolyti…