Search results for "VST"
showing 10 items of 93 documents
Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection
2012
Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuring cytokine production levels, genetic ablation of the immediate-early 1 (ie1) gene results in a significant increase in TNFα production. Intracellular staining for cytokine production and viral early gene expression shows that TNFα production is highly associated with the productively infected MΦ population of cells. The ie1- dependent phenotype of enhanced MΦ TNFα production …
Evaluation design of the Social Engagement Framework for Addressing the Chronic-disease-challenge (SEFAC): a mindfulness-based intervention to promot…
2019
Background The Social Engagement Framework for Addressing the Chronic-disease-challenge (SEFAC) project intends to empower citizens at risk of or with type 2 diabetes (T2DM) and/or cardiovascular disease (CVD) to self-manage their chronic conditions through the SEFAC intervention. The intervention combines the concepts of mindfulness, social engagement and information and communication technology support, in order to reduce the burden of citizens with chronic conditions and to increase the sustainability of the health system in four European countries. Methods A prospective cohort study with a 6-month pre-post design will be conducted in four European countries: Croatia, Italy, the Netherla…
Evaluation design of Urban Health Centres Europe (UHCE): preventive integrated health and social care for communitydwelling older persons in five Eur…
2017
BackgroundOlder persons often have interacting physical and social problems and complex care needs. An integrated care approach in the local context with collaborations between community-, social-, and health-focused organisations can contribute to the promotion of independent living and quality of life. In the Urban Health Centres Europe (UHCE) project, five European cities (Greater Manchester, United Kingdom; Pallini (in Greater Athens Area), Greece; Rijeka, Croatia; Rotterdam, the Netherlands; and Valencia, Spain) develop and implement a care template that integrates health and social care and includes a preventive approach. The UHCE project includes an effect and process evaluation.Meth…
The Association between Loneliness and Health Related Quality of Life (HR-QoL) among Community-Dwelling Older Citizens
2020
Background: This study aimed to assess the association between loneliness and Health-Related Quality of Life (HR-QoL) among community-dwelling older citizens in five European countries. We characterize loneliness broadly from an emotional and social perspective. Methods: This cross-sectional study measured loneliness with the 6-item De Jong Gierveld Loneliness Scale and HR-QoL with the 12-Item Short-Form Health Survey. The association between loneliness and HR-QoL was examined using multivariable linear regression models. Results: Data of 2169 citizens of at least 70 years of age and living independently (mean age = 79.6 ±
The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
2012
ABSTRACT Natural killer (NK) cells and CD8 + T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8 + T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8 + T-cell response and the contribution of these cells to virus control during the first days postinfection (p.i.), we used C57BL/6 mice in which NK cells are specifically activated through the Ly49H receptor engaged by the MCMV-encoded ligand m157. Our results indicate that the requirement for CD8 + T cells in early MCMV control inversely correlates with the engagement of Ly49H. W…
Longitudinal Association Between Physical Activity and Frailty Among Community-Dwelling Older Adults
2020
Objectives: To examine the longitudinal association between frequency of moderate physical activity (PA) and overall, physical, psychological, and social frailty among community-dwelling older adults older than 70 years. Second, we assessed the association between a 12-month change in frequency of moderate PA and frailty. Design: Longitudinal cohort study. Setting: Community settings in Spain, Greece, Croatia, the Netherlands, and the United Kingdom. Participants: A total of 1735 participants (61.1% female ; mean age = 79.6 years ; SD = 5.5 years). Measurements: The frequency of self-reported moderate PA was measured and classified into two categories: "regular frequency" and "low frequency…
Value creation in mobile tourism services : evaluating the value creation concerns of the Norwegian MOVE project
2007
Sammendrag på norsk og engelsk. The report presents the results of the evaluation activity specified as part of the MOVE project, a three year innovation project funded by the Research Council of Norway and seven industry and university partners. The aim of this project has been to establish a location-based electronic marketplace, offering mobile tourism services. Several pilot services including a map-based interface providing tourist guide functionality to the mobile handset, a web based tool for service providers’ registration of points of interest (POI), and two “infotainment” services (picture puzzle and riddle) has been developed. The Lofoten area was chosen as the target region for …
Ziemeļkorejas ekonomiskās attiecības un to ietekme uz politiskajām attiecībām
2019
Bakalaura darba tēma ir Ziemeļkorejas ekonomiskās attiecības un to ietekme uz politiskajām attiecībām. Šī bakalaura darba ietvaros tiek pētītas Ziemeļkorejas bilateriālās ekonomiskās attiecības ar Ķīnu, Krieviju un Indiju, kā arī tiek apskatīts, vai ar ekonomisko partnerību ir iespējams ietekmēt Ziemeļkorejas politisko rīcību. Darba teorētiskajā sadaļā tiek aplūkotas savstarpējās atkarības attiecības no starptautiskās politekonomijas perspektīvas. Darba mērķis ir noskaidrot Ķīnas, Krievijas un Indijas spējas izmantot ekonomiskās attiecības ar Ziemeļkoreju, lai ietekmētu tās politisko rīcību no 2008. gada līdz 2018. gadam. Darbā tiek izvirzīts pētnieciskais jautājums: kādai ir jābūt ekonomis…
5 gadīgu bērnu pašapziņas veicināšana kustību rotaļās
2018
Kvalifikācijas darbs izstrādāts par tēmu “Piecgadīgu bērnu pašapziņas attīstība kustību rotaļās”. Pētījuma mērķis ir pētīt piecgadīgu bērnu pašapziņas attīstības iespējas kustību rotaļās. Tēma aktuāla, jo sabiedrībā ar vien vairāk tiek runāts par bērniem ar dažādām psihiskām problēmām, taču, kad tās jau konstatētas, lielākoties iespējams tikai cīnīties ar sekām. Autorei šķita interesanti izpētīt kā ar kustību rotaļu palīdzību attīstīt bērnu pašapziņu, kas ir kā rezultāts labākai psihiskajai un fiziskajai attīstībai. Pētījums izstrādāts 2 daļās. Pirmā- teorētiskā, otrā- praktiskā. Teorētiskajā daļā sniegts pašapziņas jēdziena skaidrojums, kā arī pašapziņu ietekmējošie faktori. Īpaša uzmanība…
Latvijas Tirdzniecības un rūpniecības kamera un ekonomiskā diplomātija
2015
Šī maģistra darba tēma ir Latvijas Tirdzniecības un rūpniecības kameras (LTRK) darbība Latvijas ekonomiskajā diplomātijā. Pēdējos gadus, īpaši pēc ekonomiskās krīzes, ir samazinājusies Ārlietu ministrijas loma Latvijas ekonomiskās diplomātijas īstenošanā, bet pieaugusi citu ministriju, valsts aģentūru un ekonomiski orientētu nevalstisko organizāciju loma un iesaiste ekonomiskās diplomātijas veidošanā. LTRK iesaiste ekonomiskās diplomātijas veidošanas tīklā līdz šim nav pētīta. Pēc pētījuma veikšanas ir izdarīti sekojoši secinājumi; LTRK iekļaujas kopējā Latvijas ekonomiskās diplomātijas sadarbības tīklā. Organizācijas loma tiek vērtēta kā nozīmīga un LTRK ir iespējas iegūt un izplatīt infor…