Search results for "Variable"
showing 10 items of 1674 documents
Improved AMYR program: an algorithm for the theoretical simulation of molecular associations, including geometrical and topological characterization …
1991
Program AMYR, originally written by S. Fraga (University of Alberta, Canada), allows for the calculation of molecular associations using a pair-wise atom-atom potential. The interaction energy is evaluated through a 1/R expansion. Our improved version includes a dispersion energy term in the potential corrected by damping functions, the possibility of carrying out energy minimizations through variable metric methods, as well as the optional calculation of geometrical and topological indices. Program AMYR has been adapted also for high-performance computing and vectorization. An interactive version of the program carries out real-time molecular graphics showing simultaneously the energy prof…
Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops
2014
AbstractHypervariable loops of HIV-1 Env protein gp120 are speculated to play roles in the conformational transition of Env to the receptor binding-induced metastable state. Structural analysis of full-length Env-based immunogens, containing the entire V2 loop, displayed tighter association between gp120 subunits, resulting in a smaller trimeric diameter than constructs lacking V2. A prominent basal quaternary location of V2 and V3′ that challenges previous reports would facilitate gp41-independent gp120-gp120 interactions and suggests a quaternary mechanism of epitope occlusion facilitated by hypervariable loops. Deletion of V2 resulted in dramatic exposure of basal, membrane-proximal gp41…
Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized…
2021
Background To evaluate the efficacy of intra-alveolar administration of dexamethasone 4 mg in the control of edema, trismus, and pain resulting from the extraction of impacted lower third molars and the drug permeability through the oral mucosa by in silico prediction. Material and Methods The randomized, double-blind, split-mouth clinical trial included patients who had both impacted lower third molars in equivalent positions. Hemiarches were divided into control side when dexamethasone was administered orally and experimental side when dexamethasone was administered using the intra-alveolar route. Patients were evaluated considering edema, trismus, and pain. The permeability of dexamethas…
Isolation of the DNA minisatellite probe MZ 1.3 and its application to DNA ‘fingerprinting’ analysis
1990
Abstract A minisatellite probe, MZ 1.3, detecting hypervariable fragment patterns was isolated from a human genomic library. A repetitive sequence of 27 bp length was identified which is contained in the probe approx. 40 times. The MZ 1.3 repeat shows variable homology of 53–73% to the repetitive sequence of the protein III gene of the bacteriophage M13 genome. Polymorphic restriction fragment patterns were found with MZ 1.3 using the enzymes Hinf I, BstN I, Hae III, Mbo I, PstI PvuII , and Rsa I. An average of 18 polymorphic fragments was observed using Hinf I as enzyme. The band sharing frequency after Hinf I digestion among unrelated individuals was determined to be 23.8 ± 7.2%. An examp…
Statistical Analysis of Biological Models with Uncertainty
2020
In this contribution relevant biological models, based on random differential equations, are studied. For the sake of generality, we assume that the initial condition and the biological model parameters are dependent random variables with arbitrary probability distributions. We present a general methodology that enables us to provide a full probabilistic description of the solution stochastic process for each stochastic model. The statistical analysis is performed through the calculation of the first probability function by applying the random variable transformation technique. From the first probability density function, we can calculate any one-dimensional moment of the solution, includin…
Are Momentum Crashes Pervasive Regardless of Strategy? Evidence from the Foreign Exchange Market
2016
This paper studies the option-like behavior of popular momentum strategies implemented in foreign exchange markets. The results confirm those of Daniel and Moskowitz (2013) in finding strong option-like behavior for both momentum measures, based on the cumulative return from 12 and 6 months prior to the formation date to one month prior to the formation date. Surprisingly, there is no such evidence for the popular momentum strategy accounting for a one-month formation period.
A satellite stand-alone procedure for deriving net radiation by using SEVIRI and MODIS products
2018
Abstract In this study, a new stand-alone satellite approach for the estimation of net surface radiation (Rn) has been implemented and validated for the Italian territory. The method uses the MODIS and MSG-SEVIRI time series products and it is independent of the use of ancillary data (i.e. ground measurements). A database of daily measurements of Rn, provided by 9 stations of the FLUXNET network, was used to validate the method in different ecological scenarios in the period 2010-12. The Rn modelled by the proposed approach and the corresponding FLUXNET measurements were in good agreement, with RMSE and R2 of 19.8 Wm−2 and 0.87, respectively, at 8-days scale, and 23.3 Wm−2 and 0.92, respect…
Redundant Picard–Fuchs System for Abelian Integrals
2001
We derive an explicit system of Picard-Fuchs differential equations satisfied by Abelian integrals of monomial forms and majorize its coefficients. A peculiar feature of this construction is that the system admitting such explicit majorants, appears only in dimension approximately two times greater than the standard Picard-Fuchs system. The result is used to obtain a partial solution to the tangential Hilbert 16th problem. We establish upper bounds for the number of zeros of arbitrary Abelian integrals on a positive distance from the critical locus. Under the additional assumption that the critical values of the Hamiltonian are distant from each other (after a proper normalization), we were…
Equivalence of the Pecka–Ponec Correlation Probability and the Statistical F Significance for MLR Models
2004
In an article of this journal Pecka and Ponec [J. Math. Chem. 27 (2000) 13] have proposed, by means of a probability calculation, a method to evaluate the statistical importance of correlations obtained from multilinear regression equations involving an arbitrary number of experimental points and parameters. Here, it is demonstrated how this probability exactly coincides with a more general concept: the confidence probability of an F distribution having the appropriate degrees of freedom.
Exploring the effect of absence selection on landslide susceptibility models: A case study in Sicily, Italy
2016
Abstract A statistical approach was employed to model the spatial distribution of rainfall-triggered landslides in two areas in Sicily (Italy) that occurred during the winter of 2004–2005. The investigated areas are located within the Belice River basin and extend for 38.5 and 10.3 km 2 , respectively. A landslide inventory was established for both areas using two Google Earth images taken on October 25th 2004 and on March 18th 2005, to map slope failures activated or reactivated during this interval. Geographic Information Systems (GIS) were used to prepare 5 m grids of the dependent variables (absence/presence of landslide) and independent variables (lithology and 13 DEM-derivatives). Mul…