Search results for "Variant"
showing 10 items of 1267 documents
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
2015
Contains fulltext : 155360.pdf (Publisher’s version ) (Closed access) Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and b…
Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study
2023
Objective: Single nucleotide variants have been implicated in the response to fertility treatment and a pharmacogenomic approach may help to customize therapy based on patient genome. We aimed to evaluate the effect, individual and combined, of SYCP2L (rs2153157:G>A) and TDRD3 (rs4886238:G>A) variants on ovarian reserve, response to controlled ovarian stimulation (COS) and reproductive outcomes of women undergoing in vitro fertilization (IVF) treatment. Methods: This cross-sectional study included 149 normoovulatory women undergoing IVF. Genotyping was performed using the TaqMan real-time polymerase chain reaction method. Clinical parameters and reproductive outcomes were compared acc…
Fast equivariant JADE
2013
Independent component analysis (ICA) is a widely used signal processing tool having applications in various fields of science. In this paper we focus on affine equivariant ICA methods. Two such well-established estimation methods, FOBI and JADE, diagonalize certain fourth order cumulant matrices to extract the independent components. FOBI uses one cumulant matrix only, and is therefore computationally very fast. However, it is not able to separate identically distributed components which is a major drawback. JADE overcomes this restriction. Unfortunately, JADE uses a huge number of cumulant matrices and is computationally very heavy in high-dimensional cases. In this paper, we hybridize the…
Almost sure rates of mixing for i.i.d. unimodal maps
2002
International audience; It has been known since the pioneering work of Jakobson and subsequent work by Benedicks and Carleson and others that a positive measure set of quadratic maps admit an absolutely continuous invariant measure. Young and Keller-Nowicki proved exponential decay of its correlation functions. Benedicks and Young, and Baladi and Viana studied stability of the density and exponential rate of decay of the Markov chain associated to i.i.d. small perturbations. The almost sure statistical properties of the sample stationary measures of i.i.d. itineraries are more difficult to estimate than the "averaged statistics". Adapting to random systems, on the one hand partitions associ…
Multi-subject fMRI analysis via combined independent component analysis and shift-invariant canonical polyadic decomposition
2014
Canonical polyadic decomposition (CPD) may face a local optimal problem when analyzing multi-subject fMRI data with inter-subject variability. Beckmann and Smith proposed a tensor PICA approach that incorporated an independence constraint to the spatial modality by combining CPD with ICA, and alleviated the problem of inter-subject spatial map (SM) variability.This study extends tensor PICA to incorporate additional inter-subject time course (TC) variability and to connect CPD and ICA in a new way. Assuming multiple subjects share common TCs but with different time delays, we accommodate subject-dependent TC delays into the CP model based on the idea of shift-invariant CP (SCP). We use ICA …
A large multicenter propensity match study of sentinel lymph node biopsy feasibility in endometrioid variants of endometrial cancer
2022
Introduction: Sentinel lymph node (SLN) biopsy algorithm has been routinely applied in all endometrial endometrioid tumors, however, no studies analyzed the feasibility of SLN mapping in endometrioid variants (EV), which included villoglandular, secretory, ciliated cell, mucinous, and squamous differentiation. This study aimed to demonstrate the feasibility of SLN biopsy in EV of EC. Materials and methods: All patients undergoing minimally invasive surgical treatment for early-stage EC were included in the study. Patients were divided into 2 study groups: Group 1 which included patients with EV, and Group 2 which included patients with typical endometrioid histology. A propensity match anal…
A common extension of Arhangel'skii's Theorem and the Hajnal-Juhasz inequality
2019
AbstractWe present a result about $G_{\unicode[STIX]{x1D6FF}}$ covers of a Hausdorff space that implies various known cardinal inequalities, including the following two fundamental results in the theory of cardinal invariants in topology: $|X|\leqslant 2^{L(X)\unicode[STIX]{x1D712}(X)}$ (Arhangel’skiĭ) and $|X|\leqslant 2^{c(X)\unicode[STIX]{x1D712}(X)}$ (Hajnal–Juhász). This solves a question that goes back to Bell, Ginsburg and Woods’s 1978 paper (M. Bell, J.N. Ginsburg and R.G. Woods, Cardinal inequalities for topological spaces involving the weak Lindelöf number, Pacific J. Math. 79(1978), 37–45) and is mentioned in Hodel’s survey on Arhangel’skiĭ’s Theorem (R. Hodel, Arhangel’skii’s so…
Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021
2021
COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95…
A new lattice action for studying topological charge
1996
We propose a new lattice action for non-abelian gauge theories, which will reduce short-range lattice artifacts in the computation of the topological susceptibility. The standard Wilson action is replaced by the Wilson action of a gauge covariant interpolation of the original fields to a finer lattice. If the latter is fine enough, the action of all configurations with non-zero topological charge will satisfy the continuum bound. As a simpler example we consider the $O(3)$ $\sigma$-model in two dimensions, where a numerical analysis of discretized continuum instantons indicates that a finer lattice with half the lattice spacing of the original is enough to satisfy the continuum bound.
A family of complex potentials with real spectrum
1999
We consider a two-parameter non-Hermitian quantum mechanical Hamiltonian operator that is invariant under the combined effects of parity and time reversal transformations. Numerical investigation shows that for some values of the potential parameters the Hamiltonian operator supports real eigenvalues and localized eigenfunctions. In contrast with other parity times time reversal symmetric models which require special integration paths in the complex plane, our model is integrable along a line parallel to the real axis.