Search results for "Variants"
showing 7 items of 227 documents
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Problem Transformation Methods with Distance-Based Learning for Multi-Target Regression
2020
Multi-target regression is a special subset of supervised machine learning problems. Problem transformation methods are used in the field to improve the performance of basic methods. The purpose of this article is to test the use of recently popularized distance-based methods, the minimal learning machine (MLM) and the extreme minimal learning machine (EMLM), in problem transformation. The main advantage of the full data variants of these methods is the lack of any meta-parameter. The experimental results for the MLM and EMLM show promising potential, emphasizing the utility of the problem transformation especially with the EMLM. peerReviewed
A new constructive method of anisotropic continuous materials behavioral laws based on the theory of invariants
2010
Do childhood infections affect labour market outcomes in adulthood and, if so, how?
2020
A burgeoning body of literature suggests that poor childhood health leads to adverse health outcomes. lower educational attainment and weaker labour market outcomes in adulthood. We focus on an important but under-researched topic, which is the role played by infection-related hospitalization (IRH) in childhood and its links to labour market outcomes later in life. The participants aged 24-30 years in 2001 N =1706 were drawn from the Young Finns Study, which includes comprehensive registry data on IRHs in childhood at ages 0-18 years. These data are linked to longitudinal registry information on labour market outcomes (2001-2012) and parental background (1980). The estimations were performe…
Equilibres divariants entre la vapeur d'eau et les hydrates solides : Caractérisation de la nature de la solution solide, limites du domaine de divar…
1972
National audience; Nous avons récemment proposé (1, 2) deux modèles thermodynamiques pour les équilibres divariants entre la vapeur d'eau et les hydrates salins solides. Le premier postule l'existence d'une solution solide d'insertion d'eau dans le sel, le second postule l'existence d'une solution solide de substitution entre deux hydrates du sel. Le but de ce travail est d'établir un nouveau critère permettant de distinguer les deux modèles à partir de l'expérience et de délimiter le domaine divariant dans chacun des deux cas. Nous supposerons, sauf mention contraire, que la solution d'insertion obéit à la loi de Henry par rapport à l'eau et que la solution de substitution est idéale. Nous…