Search results for "Variations"

Karen Knorr, le faux et les variations d'une fabuliste

2012

Dans sa serie de photographies, Fables (2003-2009), Karen Knorr place sa demarche sous le signe du faux et de la fiction, par un jeu de references culturelles et de dispositifs procedant de la mise en scene, du montage et de la narration. Dans des environnements museographiques ou des espaces patrimoniaux reputes et aisement identifiables, qui sont de somptueuses demeures d’Ancien Regime ou de froides architectures modernes, la photographe provoque l’irruption improbable d’un bestiaire sauvage suscitant l’amusement ou l’inquietude. Dans chacune de ses compositions jouant avec la veracite pretee a l’image photographique, Karen Knorr cree une confrontation entre culture et nature, dont l’arti…

MDA: a MATLAB-based program for morphospace-disparity analysis

2003

A MATLAB® program that examines patterns of state-space occupation is described. Four subroutines are available with which to visualize morphospace patterns: (i) in terms of their features such as dispersion, aggregation and location, thereby allowing users to extract complementary quantitative information about how the state-space is structured, and (ii) in terms of changes in those patterns that can be compared with other biotic (e.g., extinction, origination rates) or abiotic (e.g., environmental proxy) information. The program incorporates many of the latest and most widely used statistical parameters for describing multivariate spaces. The parameters are estimated on the basis of boots…

Environmental and ontogenetic constraints on developmental stability in the spatangoid sea urchin Echinocardium (Echinoidea).

2006

13 pages; International audience; Spatangoid irregular sea urchins are detritivorous benthic organisms particularly prone to variations of environment, and their mode of growth and plate morphology make them an appropriate model to assess the effects of environmental variations. Two populations of Echinocardium flavescens were sampled in two sites of the Norwegian coast characterized by contrasted environmental conditions. Different morphological descriptors (plate areas, interlandmarks distances, overall size, and shape of the posterior ambulacra) were used to appraise interindividual variations, and fluctuating asymmetry. The comparisons were carried out using classical fluctuating asymme…

Approximating the solutions of differential inclusions driven by measures

2019

The matter of approximating the solutions of a differential problem driven by a rough measure by solutions of similar problems driven by “smoother” measures is considered under very general assumptions on the multifunction on the right-hand side. The key tool in our investigation is the notion of uniformly bounded $$\varepsilon $$-variations, which mixes the supremum norm with the uniformly bounded variation condition. Several examples to motivate the generality of our outcomes are included.

Approximation of Elliptic Hemivariational Inequalities

1999

From the previous chapter we know that there exist many important problems in mechanics in which constitutive laws are expressed by means of nonmonotone, possibly multivalued relations (nonmonotone multivalued stress-strain or reaction-displacement relations,e.g). The resulting mathematical model leads to an inclusion type problem involving multivalued nonmonotone mappings or to a substationary type problem for a nonsmooth, nonconvex superpotential expressed in terms of calculus of variation. It is the aim of this chapter to give a detailed study of a discretization of such a type of problems including the convergence analysis. Here we follow closely Miettinen and Haslinger, 1995, Miettinen…

Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12

2012

BACKGROUND: The exstrophy-epispadias complex (BEEC) is a urogenital birth defect of varying severity. The causes of the BEEC are likely to be heterogeneous, with individual environmental or genetic risk factors still being largely unknown. In this study, we aimed to identify de novo causative copy number variations (CNVs) that contribute to the BEEC. METHODS: Array-based molecular karyotyping was performed to screen 110 individuals with BEEC. Promising CNVs were tested for de novo occurrence by investigating parental DNAs. Genes located in regions of rearrangements were prioritized through expression analysis in mice to be sequenced in the complete cohort, to identify high-penetrance mutati…

Bounded solutions to the 1-Laplacian equation with a critical gradient term

2012

Identification of Copy Number Variations and Genetic Diversity in Italian Insular Sheep Breeds

2022

Simple Summary The aim of this work is to identify CNVs and perform a CNV-based population genetics analysis in five Italian sheep breeds (Barbaresca, Comisana, Pinzirita, Sarda, and Valle del Belìce). We identified 10,207 CNVs and 365 CNV regions (CNVRs). The different approaches used to disclose the genetic relationship showed that the five breeds tend to cluster in distinct groups. Gene enrichment was described for the 37 CNVRs selected considering the top 10%. Gene Ontology analysis showed that several of these genes are involved in lipid metabolism, immune response, and the olfactory pathway. CNVs represent valuable molecular resources to provide useful information for separating the p…

Analysis of extended genomic rearrangements in oncological research.

2007

Screening for genomic rearrangements is a fundamental task in the genetic diagnosis of many inherited disorders including cancer-predisposing syndromes. Several methods were developed for analysis of structural genomic abnormalities, some are targeted to the analysis of one or few specific loci, others are designed to scan the whole genome. Locus-specific methods are used when the candidate loci responsible for the specific pathological condition are known. Whole-genome methods are used to discover loci bearing structural abnormalities when the disease-associated locus is unknown. Three main approaches have been employed for the analysis of locus-specific structural changes. The first two a…

Mutated tumor alleles are expressed according to their DNA frequency

2014

AbstractThe transcription of tumor mutations from DNA into RNA has implications for biology, epigenetics and clinical practice. It is not clear if mutations are in general transcribed and, if so, at what proportion to the wild-type allele. Here, we examined the correlation between DNA mutation allele frequency and RNA mutation allele frequency. We sequenced the exome and transcriptome of tumor cell lines with large copy number variations, identified heterozygous single nucleotide mutations and absolute DNA copy number and determined the corresponding DNA and RNA mutation allele fraction. We found that 99% of the DNA mutations in expressed genes are expressed as RNA. Moreover, we found a hig…