Search results for "Vascular system"
showing 10 items of 4322 documents
CRT-724 Can the Aortic Wall Communicate with Us?
2014
Association between aortic aneurysm wall and risk of rupture or dissection. Aortic specimens were obtained from 73 patients (51 men and 22 women, whose median age 61.7± 10.7 years) undergoing surgical repair of thoracic ascending aneurysm (TAA). Histopathological and immunohistochemical analyses
Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction
2021
International audience; Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Methods. Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3–6)), medium (11 (9–13)) and high (20 (18–23)) tertiles of SYNTAX score. Results. Among the 378 patients included, there was a gradual increa…
CRT-727 Percutaneous Balloon Atrial Septostomy for Direct Left Heart Decompression in Patients on Extra Corporeal Membrane Oxygenation
2014
Severe myocardial dysfunction and added afterload from the Extra Corporeal Membrane Oxygenation (ECMO) arterial cannula may lead to significant rise in left ventricular (LV) end-diastolic and left atrial (LA) pressures. This may result in ischemia, lower likelihood of ventricular recovery and hence
Coronary Stent Strut Fractures: Classification, Prevalence and Clinical Associations
2021
Introduction. The frequency, characteristics and clinical implications of Strut fractures (SFs) remain incompletely understood. Methods and results. A total of 185 (160 patients) newer-generation drug-eluting stents (DES) were imaged. SFs were found in 21 DES (11.4%) and were classified in four patterns: one single stacked strut (41%)
Early Treatment of Systemic Juvenile Idiopathic Arthritis with Canakinumab and Complete Remission After 2 Years of Treatment Suspension: Case Report …
2019
Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease characterised by fever and arthritis. We describe the case of a 14-year-old girl hospitalised with fever associated with rash, myalgia, arthralgia and polyarticular involvement. Examinations revealed increased levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, triglycerides, leukocytes, neutrophils, lactate dehydrogenase, fibrinogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT). Bone marrow biopsy showed polyclonal leukocyte activation. A genetic study revealed a heterozygous mutation of the MEFV gene, c.442G>C (E148Q), which is typical of…
Open-label ODYSSEY APPRISE study: Interim data from the first 843 participants
2018
Background PCSK9 inhibitors (PCSK9i) have been recommended by the ESC/EAS Task Force in very high risk subjects with ASCVD and those with heterozygous familial hypercholesterolemia (HeFH) with persistent high LDL-C levels despite maximally tolerated LLT. Purpose ODYSSEY APPRISE (NCT02476006) is the first study to assess efficacy and safety at Week (W) 12 of the PCSK9i alirocumab (ALI) in a real-life setting prior to commercial availability. Methods APPRISE was an open-label, single-arm study, conducted in 16 European countries and Canada. Subjects with inadequately controlled lipid levels despite maximally tolerated LLT were included. Based on physician's judgment, participants received eit…
Management of Statin Intolerance in 2018: Still More Questions Than Answers.
2018
Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…
Shorter recovery time following high-intensity interval training induced higher body fat loss among overweight women
2018
Background: High intensity interval training (HIIT) has been widely employed as an exercise protocol to reduce fat, and also in addition, interval recovery periods are the most important factors which can have great impact on weight loss. Therefore, the aim of this study was the evaluation of different recovery time between HIIT program on metabolic responses and weight loss in overweight women. Methods: Twenty-four overweight (BMI 29.5±3.5 kg/m2) volunteer women were randomly assigned into three groups (n=8/group) to study the effects of different recovery times: (group 1; HIIT with 60/60 activity-rest ratio (sec), group 2; HIIT with 60/30 activity-rest ratio (sec), and group 3 was set as …
New observations on a pottery fragment with incised deer from the Cova de l’Or (Beniarés, Alacant)
2007
The red external surface of a vessel, decorated with an incised group of deer from Cova de l’Or, has been long considered characteristic of the application of the almagra technique. However, the results of the elemental analysis of this fragment, compared with the results of another vessel with almagra decoration from the same site, call into question the application of this technique in the first vessel. In addition, searching for parallels for the schematic incised motifs of the vessel, in both ceramic decorations and rock art, we have concluded that rather than deer the represented animals are hinds.
Evaluación del potencial efecto neuroprotector del péptido atrial natriurético (ANP) en el ictus isquémico asociado a la diabetes
2017
El ictus es una de las primeras causas de muerte, discapacidad permanente y demencia en el mundo. Del total de ictus, el 85% son de tipo isquémico y el 15% restante son de tipo hemorrágico. Aparte de la prevención, el único tratamiento establecido para el ictus isquémico agudo consiste en disolver farmacológicamente el trombo que ocluye la arteria o retirarlo mecánicamente. La neuroprotección no ha conseguido salvar la brecha entre el laboratorio y la clínica, es por esto que la protección farmacológica del cerebro y la recuperación funcional, a través de la plasticidad neuronal inducida y la reparación, siguen siendo los objetivos centrales de la investigación en ictus. En la búsqueda de n…