Search results for "Vascular"

Biogeographic patterns of base-rich fen vegetation across Europe

2014

International audience; Questions: What is the distribution of base-rich fen vegetation and the specia- list species along European biogeographic regions? How do the gradients in spe- cies composition correlate to geography and climate at continental scale? What are the implications of such patterns for the classification of these habitats?Location: Fifteen countries of Central, Western and Northern Europe.Methods: We compiled a vegetation plot database of base-rich fens and related communities including vascular plants and bryophytes. The initial data set with 6943 plots was filtered according to the presence of specialists using discriminant analysis. We used DCA to analyse the correlatio…

Acute heart failure due to giant left atrium: remote ECLS implantation for interhospital transfer and bridging to decision

2018

AbstractBackgroundRemote extracorporeal life support (ECLS) implantation and mobile ECLS are increasingly applied to enable the treatment of patients with refractory heart failure at specialized care centers. Giant left atrium (GLA) is a rare cause but may lead to acute and devastating heart failure.Case reportAcute heart failure that gave rise to a prolonged period of out-of-hospital cardiopulmonary resuscitation in a patient who underwent remote ECLS implantation was found to have resulted from a GLA of impressive dimensions. There having no reasonable option for immediate surgical therapy, the patient was successfully bridged to recovery with a view to subsequent heart transplantation.Co…

Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity

2019

Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This chang…

Intentional interruptions during compression only CPR: a way to increase adherence to CPR and compressions' quality?

2021

Papel del grosor íntima-media en carótida y del TC de coronarias en la detección temprana de aterosclerosis en la mujer y posible modulación por poli…

2016

La enfermedad cardiovascular es una de las primeras causas de muerte . Su fundamento biológico es la aterosclerosis, un proceso inflamatorio. Una parte de la lucha contra ella se ha centrado en la actuación sobre los factores de riesgo modificables. Paralelamente, hay un interés creciente en la detección de biomarcadores fiables, que sean capaces de identificar la presencia de aterosclerosis en fases tempranas, cuando el riesgo clínico es bajo. Las pruebas de imagen están siendo importantes en este contexto. Aunque ha sido tradicionalmente asociada con el género masculino, la enfermedad cardiovascular también representa la principal causa de morbi-mortalidad en las mujeres. De hecho, cualqu…

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

2020

Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity.

The role of in situ species diversification for the evolution of high vascular plant species diversity in the European Alps—A review and interpretati…

2017

Abstract By harbouring ca. 3500 native vascular plant species in an area of ca. 170 000 km2, the European Alps represent a region of very high species diversity. Using the most recently published flora of the area and phylogenetic literature, I here review which proportion of the endemic flora of the Alps is the result of in situ diversification, i.e., of diversification in the area and (largely) restricted to the area. There exist only very few and mostly species-poor species diversifications in the Alps, accounting for ca. 1.2% of the native and for ca. 9% of the endemic flora of the Alps. In contrast to this, ca. 33% of the endemic species of the Alps belong to lineages widespread in the…

ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.

2018

CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…

The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases

2018

International audience; Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes. The relationship between bone regulatory proteins and vascular biology has attracted attention, and it has been suggested that OPG may medi…

The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: Implications in rheumatoid…

2009

Objective. Complement activation products contribute to a large number of inflammatory diseases, including RA. We have investigated whether osteoprotegerin (OPG) may concur with the soluble terminal complement complex (SC5b-9) to the inflammatory cascade characterizing RA. Methods. Levels of SC5b-9 and OPG in the plasma and SF of patients with active RA were determined by ELISA. The presence of SC5b-9 and OPG in RA synovial lesions was analysed by immunohistochemistry. Cultured endothelial cells were used for in vitro leucocyte/endothelial cell adhesion assays. In addition, endothelial cells were exposed to SC5b-9 in order to evaluate the effects on the production of OPG protein, as well as…