Search results for "Vascular"
showing 10 items of 10708 documents
Pediatric Psychology
2021
The attention and the intervention of psychology in the field of pediatrics, especially regarding mothers and childcare, whether in a hospital or not, is extremely longstanding [...]
Corrigendum to "Molecular diagnosis of hypobetalipoproteinemia: An ENID review" [Atherosclerosis 195 (2) (2007) 19-27].
2016
Conceptos básicos en biología molecular relacionados con la genética y la epigenética
2017
Resumen La observacion de que «lo mismo no sirve para todos» en la prevencion y el tratamiento de las enfermedades cardiovasculares, entre otras, ha propulsado el concepto de medicina de precision. Su objetivo es proporcionar las mejores intervenciones basadas en la informacion adicional que aporta el genoma. El genoma humano se compone de miles de millones de pares de bases que contienen un codigo que controla como se expresan los genes. Este codigo depende de reguladores no estaticos que rodean el ADN y constituyen el epigenoma. Ademas, los factores ambientales tambien desempenan un papel importante en esta compleja regulacion. Se presenta una perspectiva general sobre los conceptos basic…
El suero de seno coronario tras un infarto de miocardio induce angiogénesis y reparación de la obstrucción microvascular. Implicación del factor indu…
2018
Resumen Introduccion y objetivos El objetivo es estudiar la angiogenesis coronaria inducida por el suero coronario y la implicacion del factor inducible por hipoxia-1A (FIH-1A) en la reparacion de la obstruccion microvascular (OMV) tras un infarto agudo de miocardio (IAM). Metodos Se indujo un IAM en cerdos mediante oclusion coronaria durante 90 min. Se dividio a los animales entre 1 grupo de control y 4 grupos con IAM: sin reperfusion y 1 min, 1 semana y 1 mes tras la reperfusion. Se cuantificaron la OMV y la densidad microvascular. Se determino la capacidad angiogenica del suero coronario mediante una prueba de tubulogenesis in vitro. Se determinaron las concentraciones circulantes del FI…
Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique
2016
Resume Le systeme endocannabinoide (SEC) est compose de recepteurs couples aux proteines G : Cannabinoid type 1-receptor (CB 1 -R) et Cannabinoid type 2-receptor (CB 2 -R), de leurs ligands endogenes (anandamide [AEA], et 2-acylglycerol [2-AG]), et des enzymes responsables de leur synthese et de leur degradation. Bien que les recepteurs CB 1 -R et CB 2 -R furent initialement decrits au niveau du systeme nerveux central, ils sont presents dans de nombreux tissus peripheriques, ou ils sont impliques dans le metabolisme, la croissance, et l’inflammation. Apres le retrait commercial du rimonabant, pour des effets secondaires psychiatriques, un agoniste inverse du recepteur CB 1 (CB 1 -R), desti…
2021
Lipids contained in the plasma membrane of platelets play an important role in platelet function. Modifications in the lipid composition can fluidify or rigidify the environment around embedded receptors, in order to facilitate the access of the receptor by the drug. However, data concerning the lipid composition of platelet plasma membrane need to be updated. In addition, data on the impact of drugs on plasma membrane composition, in particular antiplatelet agents, remain sparse. After isolation of platelet plasma membrane, we assessed, using lipidomics, the effect of ticagrelor, a P2Y12 antagonist, and its active metabolite on the lipid composition of these plasma membranes. We describe t…
Recombinant factor VIII: past, present and future of treatment of hemophilia A.
2018
The development of recombinant factor VIII (rFVIII) was initially driven by the necessity to treat hemophilia A (HA) patients with FVIII concentrates without the risk of transmitting infectious agents. Over the last three decades the safety of rFVIII has been further improved by completely removing animal or human proteins from the manufacturing process, so that patients would not be exposed to known or emerging pathogens. Recent efforts have concentrated on improving the expression of rFVIII, reducing its immunogenicity and enhancing its pharmacokinetic (PK) behavior. These new goals have been possible thanks to the develop-ment of biotechnology and a better knowledge of the function and s…
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease
2019
Objective— To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. Approach and Results— This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and…
Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease
2021
Platelets are the main players in thrombotic diseases, where activated platelets not only mediate thrombus formation but also are involved in multiple interactions with vascular cells, inflammatory components, and the coagulation system. Although in vitro reactivity of platelets provides information on the function of circulating platelets, it is not a full reflection of the in vivo activation state, which may be relevant for thrombotic risk assessment in various disease conditions. Therefore, studying release markers of activated platelets in plasma is of interest. While this type of study has been done for decades, there are several new discoveries that highlight the need for a critical a…