Search results for "Vectors"
showing 10 items of 601 documents
Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter …
2001
PURPOSE: To study the additional benefit from adenoviral p53 gene therapy in patients undergoing first-line chemotherapy for advanced non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Twenty-five patients with nonresectable NSCLC were enrolled in an open-label, multicenter phase II study of three cycles of regimen A, carboplatin (area under the curve, 6; day 1) plus paclitaxel (175 mg/m2, day 1), or regimen B, cisplatin (100 mg/m2, day 1) plus vinorelbine (25 mg/m2, days 1, 8, 15, and 22) in combination with intratumoral injection of 7.5 × 1012 particles of SCH 58500 (rAd/p53, day 1). Responses of individual tumor lesions were assessed after each cycle, and gene transfer was examin…
Gold Nanoparticle-Assisted Virus Formation by Means of the Delivery of an Oncolytic Adenovirus Genome
2020
[EN] Oncolytic adenoviruses are a therapeutic alternative to treat cancer based on their ability to replicate selectively in tumor cells. However, their use is limited mainly by the neutralizing antibody (Nab) immune response that prevents repeated dosing. An alternative to facilitate the DNA access to the tumor even in the presence of anti-viral Nabs could be gold nanoparticles able to transfer DNA molecules. However, the ability of these nanoparticles to carry large DNA molecules, such as an oncolytic adenovirus genome, has not been studied. In this work, gold nanoparticles were functionalized with different amounts of polyethylenimine to transfer in a safe and efficient manner a large on…
Transparent boundary condition for acoustic propagation in lined guide with mean flow
2008
A finite element analysis of acoustic radiation in an infinite lined guide with mean flow is studied. In order to bound the domain, transparent boundary conditions are introduced by means of a Dirichlet to Neumann (DtN) operator based on a modal decomposition. This decomposition is easy to carry out in a hard‐walled guide. With absorbant lining, many difficulties occur even without mean flow. Since the eigenvalue problem is no longer selfadjoint, acoustic modes are not orthogonal with respect to the L2‐scalar product. However, an orthogonality relation exists which permits writing the modal decomposition. For a lined guide with uniform mean flow, modes are no longer orthogonal but a new sca…
Eigenvectors of k–ψ-contractive wedge operators
2008
Abstract We present new boundary conditions under which the fixed point index of a strict- ψ -contractive wedge operator is zero. Then we investigate eigenvalues and corresponding eigenvectors of k – ψ -contractive wedge operators.
The Probability Law for Generic Density Operators
2020
In this chapter, the probability law of the non-null eigenstates of a generic density operator—studied in the previous chapter—is determined, by showing that given the composite system and the subsystem being considered, a mapping arises which associates a universal probability distribution to the non-null eigenstates of the generic density operator. We thus recover the Born statistical interpretation without having assumed it as a postulate.
Existence and stability of periodic solutions in a neural field equation
2017
We study the existence and linear stability of stationary periodic solutions to a neural field model, an intergo-differential equation of the Hammerstein type. Under the assumption that the activation function is a discontinuous step function and the kernel is decaying sufficiently fast, we formulate necessary and sufficient conditions for the existence of a special class of solutions that we call 1-bump periodic solutions. We then analyze the stability of these solutions by studying the spectrum of the Frechet derivative of the corresponding Hammerstein operator. We prove that the spectrum of this operator agrees up to zero with the spectrum of a block Laurent operator. We show that the no…
MR3667002 Reviewed Vogt, Dietmar(D-BUW) Hadamard operators on D′(Ω). (English summary) Math. Nachr. 290 (2017), no. 8-9, 1374–1380. 46F10 (46F12 47B3…
2017
In this paper, the Hadamard operators, i.e. a particular class of continuous linear operators on D′(Ω) whose set of eigenvectors is the class of monomials, are considered on an open set Ω⊂Rd. Specifically, Hadamard operators L are characterized by the multiplicative convolution, that is, there exists a distribution T such that L(S)=S⋆T, where the multiplicative convolution ⋆ is defined by (S⋆T)ϕ=Sy(Txϕ(xy)). To obtain this characterization, the author defines a particular extension to D(Ω˜), where Ω˜:=⋃a∈RdaΩ, of the transpose of Hadamard operators. This result is a generalization of a previous work of the author where only the case Ω=Rd was considered.
Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum
2019
Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β-hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungus Cochliobolus lunatus. In this work, we have identified the genes encoding the cytochrome CYP103168 and the reductase CPR64795 of C. lunatus responsible for the 11β-hydroxylase activity in this fungus, which is the key step for the preparative synthesis of cortisol in industry. A recombinant Corynebacterium glutamicum strain harbouring a plasmid expressing both genes forming a synthetic bacterial operon was able to 11β-hydroxylate several steroids as subs…
Generalized modulational instability in multimode fibers: Wideband multimode parametric amplification
2015
In this paper intermodal modulational instability (IM-MI) is analyzed in a multimode fiber where several spatial and polarization modes propagate. The coupled nonlinear Schr\"odinger equations describing the modal evolution in the fiber are linearized and reduced to an eigenvalue problem. As a result, the amplification of each mode can be described by means of the eigenvalues and eigenvectors of a matrix that stores the information about the dispersion properties of the modes and the modal power distribution of the pump. Some useful analytical formulas are also provided that estimate the modal amplification as function of the system parameters. Finally, the impact of third-order dispersion …
Wave Propagation in a 3-D Optical Waveguide
2003
In this paper we study the problem of wave propagation in a 3-D optical fiber. The goal is to obtain a solution for the time-harmonic field caused by a source in a cylindrically symmetric waveguide. The geometry of the problem, corresponding to an open waveguide, makes the problem challenging. To solve it, we construct a transform theory which is a nontrivial generalization of a method for solving a 2-D version of this problem given by Magnanini and Santosa.\cite{MS} The extension to 3-D is made complicated by the fact that the resulting eigenvalue problem defining the transform kernel is singular both at the origin and at infinity. The singularities require the investigation of the behavio…