Search results for "Ventricle"

Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents

2002

The lateral walls of the forebrain lateral ventricles are the richest source of stem cells in the adult mammalian brain. These stem cells give rise to new olfactory neurons that are renewed throughout life. The neurons originate in the subventricular zone (SVZ), migrate within the rostral extension (RE) of the SVZ along the rostral migratory stream (RMS) within tube-like structures formed of glial cells, to eventually reach the olfactory bulb (OB). We demonstrate that, contrary to the current view, multipotential (neuronal-astroglial-oligodendroglial) precursors with stem cell features can be isolated not only from the SVZ but also from the entire RE, including the distal portion within the…

Three-Dimensional Surface Display in Blood Pool Gated SPECT

1994

In 14 patients (4 in good health and 10 with coronary heart disease) a blood pool gated single photon emission computed tomography (SPECT) was executed. The transaxial slices of the cardiac blood pool were reconstructed. A three-dimensional surface display was employed for the analysis of the tomographic data. A fixed distance, a fixed threshold (50%), and some different planes of view were employed. The test permitted visualiza tion of the ventricular and the atrial movements in all patients. The right ventricle was clearly seen in the right anterior oblique plane of view. The aortic beating was seen. In normal patients the left ventricle, clearly seen in left anterior oblique plane, shra…

Heart infarct in NOD-SCID mice: therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34+KDR+ cells

2004

Hematopoietic (Hem) and endothelial (End) lineages derive from a common progenitor cell, the hemangioblast: specifically, the human cord blood (CB) CD34+KDR+ cell fraction comprises primitive Hem and End cells, as well as hemangioblasts. In humans, the potential therapeutic role of Hem and End progenitors in ischemic heart disease is subject to intense investigation. Particularly, the contribution of these cells to angiogenesis and cardiomyogenesis in myocardial ischemia is not well established. In our studies, we induced myocardial infarct (MI) in the immunocompromised NOD-SCID mouse model, and monitored the effects of myocardial transplantation of human CB CD34+ cells on cardiac function.…

Ventricular arrhythmias in children: The uselessness of MRI

2008

Ventricular-vascular coupling in hypertension: methodological considerations and clinical implications.

2014

The present review is addressed to analyse the complex interplay between left ventricle and arterial tree in hypertension. The different methodological approaches to the analysis of ventricular vascular coupling in the time and frequency domain are discussed. Moreover, the role of hypertension-related changes of arterial structure and function (stiffness and wave reflection) on arterial load and how ventricular-vascular coupling modulates the process of left ventricular adaptation to hypertension are analysed.The different interplay between vascular bed and left ventricle emerges as the pathophysiological basis for the development of the multiple patterns of ventricular structural adaptatio…

Re-ventriculostomy for treatment of obstructive hydrocephalus in cases of stoma dysfunction.

2002

In this article, 12 re-ventriculostomies in the treatment for obstructive hydrocephalus are described. The etiology of the hydrocephalus was a benign aqueductal stenosis in 9 patients, a tumor around the aqueduct in 2 patients and intraventricular bleeding in one patient. In all cases the initial ventriculostomy was successful, but after a time interval of 2 weeks to 6 years the patients developed similar clinical symptoms as preoperatively. In all except one case the radiological findings spoke in favour of stoma closure. Intraoperatively the stoma was completely closed in 9 patients and in 3 patients a subtotal closure was observed. In all cases a re-ventriculostomy was performed bluntly …

Endoscopic transventricular third ventriculostomy through the lamina terminalis

2010

Object Endoscopic third ventriculostomy (ETV) has become a well-accepted option for obstructive hydrocephalus. However, standard ventriculostomy at the floor of the third ventricle might not be feasible under certain conditions. Here, the authors report in detail on their initial experience with an alternative option of endoscopic ventriculostomy through the lamina terminalis via a transventricular route. Methods Endoscopic third ventriculostomy through the lamina terminalis from a transventricular transforaminal route was evaluated in 4 cadaveric human heads and in 4 clinical cases. Results In all 4 human cadavers, an opening of the lamina terminalis via a transventricular approach could …

Left-Ventricle Segmentation of SPECT Images of Rats

2015

Single-photon emission computed tomography (SPECT) imaging of the heart is helpful to quantify the left-ventricular ejection fraction and study myocardial perfusion scans. However, these evaluations require a 3-D segmentation of the left-ventricular wall on each phase of the cardiac cycle. This paper presents a fast and interactive graph cut method for 3-D segmentation of the left ventricle (LV) of rats in SPECT images. The method is carried out in three steps. First, 3-D sampling of the LV cavity is made in a spherical-cylindrical coordinate system. Then, a graph-cut-based energy minimization procedure provides delineation of the myocardium centerline surface. From there, it is possible to…

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

2017

Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells …

Ultrastructure of the conus arteriosus ofScyliorhinus stellaris

1989

The functional morphology of the fourth chamber of the fish heart, the bulbus arteriosus, differs in teleosts and elasmobranchs. In elasmobranchs, this chamber is referred to as the conus arteriosus because its wall is made up of myocardial tissue in addition to elastic tissue. As a result of this feature, the function of the conus is very specialized. We report the basic ultrastructure of the wall of the conus arteriosus in the elasmobranch Scyllium stellare. The wall consists of three layers: the outer epicardial, the middle myocardial, and the inner endocardial layer. The outer layer is composed of the visceral pericardium consisting of cuboidal mesothelial cells, beneath which numerous …