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Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome
2021
The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role …
Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis
2020
Abstract Fingolimod is an approved treatment for relapsing–remitting multiple sclerosis (MS), and its properties in different pathways have raised interest in therapy research for other neurodegenerative diseases. Fingolimod is an agonist of sphingosine-1-phosphate (S1P) receptors. Its main pharmacologic effect is immunomodulation by lymphocyte homing, thereby reducing the numbers of T and B cells in circulation. Because of the ubiquitous expression of S1P receptors, other effects have also been described. Here, we review preclinical experiments evaluating the effects of treatment with fingolimod in neurodegenerative diseases other than MS, such as Alzheimer’s disease or epilepsy. Fingolimo…
GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome
2012
The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.
Impact of extrafine formulations of inhaled corticosteroids/long-acting beta-2 agonist combinations on patient-related outcomes in asthma and COPD
2014
Nicola Scichilone,1 Alida Benfante,1 Luca Morandi,2 Federico Bellini,2 Alberto Papi21Biomedical Department of Internal and Specialist Medicine, Section of Pulmonology, University of Palermo, Italy; 2Respiratory Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, ItalyAbstract: Asthma and chronic obstructive pulmonary disease (COPD) are among the most common chronic diseases worldwide, characterized by a condition of variable degree of airway obstruction and chronic airway inflammation. A large body of evidence has demonstrated the importance of small airways as a pharmacological target in these clinical conditions. Despite a deeper understanding of the pathophysiologic…
Essential oils and their applications in agriculture and agricultural products: a literature analysis through VOSviewer.
2022
In agriculture, more attention has been paid to limit the amount of chemical plant protection products. A potential alternative solution has been found in essential oils (EOs), which appear as promising candidates for their properties (safe, bioactive, biodegradable products) in managing plant diseases in agriculture. Therefore, a co-occurrence analysis was carried out on the available literature on Scopus database, through network maps created by VOSviewer software in order to identify the EOs used in agriculture, agricultural products and their target application. USA and India appeared as the most productive countries in terms of documents and citations followed by Iran and Italy. The co…
The pesticides use and the risk for head and neck cancer: A review of case-control studies
2020
Background Tobacco, alcohol consumption, and HPV infection are the most common risk factors for head and neck cancer (HNC). Despite of this, recent evidences are growing on the association between long-term exposure to pesticides and the risk of chronic diseases, including different types of cancer. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of HNCs. Material and Methods A literature search of the case-control studies was conducted in the PubMed, Web of science and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN 50) checklist. Res…
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
2014
The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…
A? * algebra of pseudodifferential operators on noncompact manifolds
1988
On montre qu'une classe d'operateurs pseudodifferentiels d'ordre zero a la propriete d'invariance spectrale
Pieri’s 1900 Point-and-Motion Memoir
2021
This chapter contains an English translation of Mario Pieri’s 1900a memoir, On Elementary Geometry as a Hypothetical Deductive System: Monograph on Point and on Motion.1 By elementary geometry, Pieri meant Euclidean geometry as taught then in elementary courses, except for the theorems dependent on the Euclidean parallel axiom.
Collating evidence on the restoration efforts of the seagrass Posidonia oceanica: current knowledge and gaps
2022
Seagrass meadows are important shallow coastal ecosystems due to their contribution to enhancing biodiversity, nu-trient cycling, carbon burial, and sediment stabilisation, but the maintenance of their integrity has been threatened by several anthropogenic disturbances. Active restoration is considered a reliable strategy to enhance recovery of seagrass ecosystems, and decision making for correct seagrass restoration management requires relying on valuable informa-tion regarding the effectiveness of past restoration actions and experimental efforts.Previous experimental efforts and human-mediated active restoration actions of the slow growing seagrass Posidonia oceanica have been collated h…