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RESEARCH PRODUCT

GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

Carmen VidalPilar AlamáJuan GilesJosé Bellver

subject

Agonistendocrine systemmedicine.medical_specialtymedicine.drug_classEndocrinology Diabetes and MetabolismOvarian hyperstimulation syndromeStimulationReview ArticleAndrologyOvarian Hyperstimulation SyndromeInternal medicinemedicineGnRH AntagonistPregnancyGnRH Agonistbusiness.industryPreventionGnRH AntagonistOocytemedicine.diseaseOvarian Stimulationmedicine.anatomical_structureEndocrinologyDisease preventionbusinesshormones hormone substitutes and hormone antagonists

description

The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

yearjournalcountryeditionlanguage
2012-07-09International Journal of Endocrinology and Metabolism
https://doi.org/10.5812/ijem.5034