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Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
2021
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used…
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
2020
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells), in interfollicular dermis, and in the hypodermis tissue. These cells are expected to play a major role in regulating skin regeneration and aging-associated morphologic disgraces and structural deficits. ADSCs are known to proliferate and differentiate into skin cells to repair damaged or dead cells, but also act by an autocrine and paracrine pathway to activate cell regeneration and the healing process. During wound healing, ADSCs have a great ability in migration to be recruited rapidly…
Microneedle-Based Delivery: An Overview of Current Applications and Trends
2020
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the …
EDM and Ecstasy: the lived experiences of electronic dance music festival attendees
2017
Attendance at large-scale music festivals has captivated a global interest in these spectacular experiences, yet little is known about the lasting benefits and personal changes individuals incur following this event. This study aims to provide a comprehensive exploration of the lived experiences of individuals who attended a multi-day electronic dance music festival. The present study was primarily interested in the perceived beneficial changes within the individual, following their festival experience. We investigated if first-time festival attendees perceived changes differed to those of returning individuals. Semi-structured qualitative interviews were used to collect data from 12 indivi…
Self-compassion and social functioning of people – research review
2015
Abstract Self-compassion is considered to be a healthy and adaptive attitude towards oneself, occurring both as a feature, as well as a state. Self-compassionate attitude towards oneself is composed of: a) kindness and understanding given to oneself b) mindfulness of one’s own experiences and c) a sense of community of experiences with humanity. Compassion towards oneself is structurally and functionally distinct from the self-commiseration and self-pity that lead to worse adaptation. Research shows that self-compassion is associated with better regulation of negative emotions. Neff (2003 a) in her theoretical assumption states that due to more effective emotion regulation , people with a h…
The discursive construction of leader identity: Tim Cook in a broadcast interview
2016
Tämän tutkimuksen aiheena on tutkia johtajaidentiteetin rakentumista diskursiivisesta näkökulmasta. Sosiolingvistisen tutkimussuuntauksen piirissä identiteetin rakentuminen nähdään kielellisenä prosessina: identiteetti rakentuu vuorovaikutuksessa diskursiivisten prosessien kautta. Tätä taustaa vasten tavoitteena on selvittää, kuinka Applen toimitusjohtaja Tim Cookin johtajaidentiteetti rakentuu haastattelutilanteessa erilaisten kielellisten keinojen kautta. Tutkimuksen keskiössä ovat erityisesti kielellisen asemoinnin keinot eli erilaisten lyhyt- ja pidempiaikaisten identiteettiasemien osoittaminen niin Cookin itsensä kuin haastattelijan toimesta. Teoreettinen viitekehys koostui Bucholtzin …
Suomalaisen sosiaalipolitiikan ja liikuntapolitiikan yhtenevät päämäärät 1920-80-luvuilla
2018
Artikkelin tavoitteena on kuvailla sosiaalipolitiikan ja liikuntapolitiikan suhdetta sekä suhteessa tapahtuneita muutoksia suomalaisessa yhteiskunnassa 1920–80-luvuilla. Keskeisiä tutkimuskysymyksiä ovat (1) millaista samansuuntaista tavoitteellisuutta sosiaalipolitiikassa ja liikuntapolitiikassa on ilmennyt sekä (2) miten sosiaali- ja liikuntapoliittiset käsitykset politiikkalohkojen toimijoista ja toimijasuhteista ovat muuttuneet eri aikakausilla. Artikkelilla luodaan myös ymmärrystä väestön hyvinvoinnin edistämiseen liittyvän poikkihallinnollisen ja sektorirajat ylittävän yhteistyön historiasta sekä yhteistyöhön eri aikakausilla vaikuttaneista tekijöistä. Tutkimusmenetelmä on integroiva …
The use of Electronic Information Systems in social work : A scoping review of the empirical articles published between 2000 and 2019
2022
Sähköisiä tietojärjestelmiä käytetään laajasti sosiaalityössä, mutta empiirisiä tutkimustuloksia niiden käytöstä ei ole vielä analysoitu ja levitetty. Tässä kartoittavassa kirjallisuuskatsauksessa tarkasteltiin vuosien 2000–2019 julkaistun 36 tutkimusartikkelin tuloksia selvittäen, mitkä teemat korostuivat tutkimuksissa sekä millaisia tutkimusaukkoja oli tunnistettavissa. Analyysin perusteella tunnistettiin neljä pääteemaa: (1) tietojärjestelmien käytön vaikutukset sosiaalityöhön; (2) tekijät, joilla on vaikutusta tietojärjestelmien käytössä; (3) sosiaalityöntekijöiden toimintatavat tietojärjestelmien käytössä ja (4) tietojärjestelmien kehittäminen sosiaalityöntekijöiden kanssa. Tulosten mu…
The contested concept of vulnerability : a literature review
2020
The concept of vulnerability is widely used in the social sciences as well as in policy making, health and social care services and in social work, referring to a variety of groups or individuals, but it has rarely been theoretically defined or analysed. This article provides a literature review on how vulnerability has been used and defined in academic, peer-reviewed articles published in international social science journals between 2000 and 2016. The aim is to analyse and clarify critically the concept for social work research. The article analyses themes and topics connected to vulnerability, how gender is related to vulnerability and how vulnerability is conceptualised in these article…