Search results for "Virchow"

Anatomy and physiology of cisternostomy

2016

Cisternostomy is defined as opening the basal cisterns to atmospheric pressure. This technique helps to reduce the intracranial pressure in severe head trauma as well as other conditions when the so-called sudden “brain swelling” troubles the surgeon. We elaborated the surgical anatomy of this procedure as well as the proposed physiology of how cisternostomy works. This novel technique may change the current trends in neurosurgery.

Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies

2019

Objective: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. Method: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms. Results: We showed that the zero-inflated negative binomial (ZINB) distribution provided the best power for modeling ADHD symptoms. ZINB reveals a genetic variant, rs273342…

Exploring the Virchow-Robin spaces function: A unified theory of brain diseases.

2016

Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different path…

Letter in response to “ COVID ‐19, Virchow's triad and thromboembolic risk in obese pregnant women”

2021

Lo Stato cellulare e i suoi cittadini: metafore bio-politiche sulla questione dell’individualità cellulare

2014

The concept of cell, more than any other biological concept, has been modelled on three powerful metaphors: in a morphological perspective, the cell has been defined Baustein, the brick or elementary unit of the body; from the physiological point of view, it has been associated to a chemical laboratory and finally, in a systemic view, it has been compared to the citizen of the cellular state. The pathologist Rudolf Virchow and the zoologist Ernst Haeckel showed the philosophical and aesthetic potential of the latter metaphor, opening two different perspectives on a crucial problem in the science of living: the problem of the definition of biological individual.

COVID ‐19, thromboembolic risk, and Virchow's triad: Lesson from the past

2020

Abstract COronavirus Infectious Disease which started in 2019 (COVID‐19) usually presents with the signs and symptoms of pneumonia. However, a growing number of recent reports highlight the fact that the infection may be by far more than only a respiratory disease. There is evidence of an increased thromboembolic risk in COVID‐19 patients, with a variety of manifestations in terms of ischemic stroke, deep vein thrombosis, acute pulmonary embolism, acute myocardial infarction, systemic arterial embolism, and placental thrombosis. The German physician Rudolph Virchow, about two centuries ago, described three pivotal factors contributing together to thromboembolic risk: endothelial injury, hyp…