Search results for "Vt"
showing 10 items of 136 documents
The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells
2007
The human PVT-1 gene is located on chromosome 8 telomeric to the c-Myc gene and it is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. It has been proposed that PVT-1 regulates c-Myc gene transcription over a long distance. To get new insights into the functional relationships between the two genes, we have investigated PVT-1 and c-Myc expression in normal human tissues and in transformed cells. Our findings indicate that PVT-1 expression is restricted to a relative low number of normal tissues compared to the wide distribution of c-Myc mRNA, whereas the gene is highly expressed in many transformed cell types including neuroblastom…
Parametrical design of Split-Way CVTs
2016
La presente attività di ricerca si svolge presso l’Università degli Studi di Palermo nell’ambito di un corso di dottorato in Ingegneria dell’Innovazione Tecnologica, il quale si pone l’obiettivo di delineare una procedura semplice, generale e modulare per la progettazione, la modellistica ed il dimensionamento di trasmissioni meccaniche innovative, eventualmente coadiuvate da dispositivi di accumulo d’energia. In particolare, una crescente sensibilità verso le problematiche connesse all’efficienza energetica, e la conseguente ascesa dell’auto ibrida, ha fatto sì che negli ultimi anni le trasmissioni di tipo Split-way suscitassero, specie in virtù della loro capacità di consentire un certo s…
Split-Way CVTs: Parametric Analysis and Design
The thesis provides a parametric analytical method for the analysis and design of power-split continuously variable transmissions, which represent the state of the art for heavy-duty vehicles and hybrid electric cars. The functioning of any driveline is described by mean of a simple set of kinematic parameters, regardless of the constructive scheme. The calculation of the control torques remains straightforward even when both inertial effects and mechanical losses are taken into account. A simple design procedure is described and generalized in order to address any order of driveline, including multimode transmissions. The final layout is generated additively, without the need to analyze hu…
Effectiveness and safety of a new helmet CPAP configuration allowing tidal volume monitoring in patients with COVID-19.
2021
Abstract Background High generated tidal volumes (Vt) have been correlated with higher risk of self-induced lung injury and worse clinical outcome. This study aimed to evaluate the effectiveness and safety of a new helmet continuous positive airway pressure delivered (h-CPAP) configuration allowing Vt monitoring in patients affected by COVID-19. Methods This prospective observational study was performed in the respiratory intermediate care unit of University Hospital in Turin, Italy, between March 24th, and June 15th, 2020. Included patients were treated with CPAP via a single-limb intentional leak configuration by a turbine-driven ventilator, provided with a dedicated patch. Effectiveness …
"I martiri della civiltà greca”: M.I. Rostovtzeff sugli Acta Alexandrinorum
2005
L’articolo analizza l’interpretazione degli Acta Alexandrinorum fornita da M.I. Rostovtzeff, dai quali emergerebbero gli alti ideali della cultura greca e della tradizione di Alessandria di fronte all’imperium Romanum.
Uncertainty at Work How to Regulate it through Leadership in order to improve the Quality of Work Life?
2022
This thesis manuscript focuses on factors able to regulate the uncertainty of people at work. Due to the constant evolution of the organizational world, uncertainty is increasingly becoming a factor with which to combine in different contexts about work. This factor constitutes a risk for individuals due to its aversive nature. In this perspective we have been interested, on the one hand, about theories concerning the concept of uncertainty. This allowed us to better understand and delimit the concept. On the other hand, we looked for ways to regulate uncertainty through the concept of leadership. This led us to consider this regulation as being either potentially possible through a directi…
Global Efficiency of Power-Split Hybrid Electric Powertrain
2021
The development of a proper energy management strategy in hybrid electric vehicles is crucial to pursue the best balance between emissions reduction and performance. In this respect, this paper addresses a straightforward method to investigate the behaviour of the hybrid powertrain in steady-state operation in terms of speeds and torques both of the thermal engine and the electric machines. The procedure takes into account the conversion power losses in the internal combustion engine and the electric unit and the mechanical power losses occurring in the power-split transmission. This enables the calculation of a set of maps describing the global efficiency of the hybrid powertrain and the p…
Functional design of power-split CVTs: An uncoupled hierarchical optimized model
2017
Abstract This paper provides a new model for the preliminary design of compound power-split CVTs. Unlike the existing models, the presented method allows the engineers to prioritize functionality and efficiency of the transmission, while delaying the choice of the involved gear sets’ layout as long as possible. The design approach follows a specific priority order, and each step deals with one particular issue, without mutual interference. A smart design-chart eases the assessment and the comparison of the only eligible alternatives, and eventually leads to a final feasible constructive scheme, which can be an excellent concept for further optimization and implementation. Moreover, the mode…
GNSS/WEB-GIS heliport planning in a regional area for VTOL transport services
2014
The role of the helicopter in airport planning and air traffic analysis is fundamental with re-gard to both the qualitative and quantitative increasing of the demand and the technical en-hancement of the aircrafts. This leads to infrastructural and organizational issues. Such a need finds a plausible solution in the implementation of a helicopter service and the creation of a heliport network linked to the airport, road and rail systems. Part of the issue of airport planning and design is the study of helicopters’ utilization for purposes other than commer-cial such as aerial work and civil protection. The helicopter is indeed essential in all those uses based on the capabilities that it ha…
Prediction of driving performance of a hybrid vehicle with CVT transmission
2009
The purpose of this work is the description of the phenomenology of driving behaviour of a production car characterized by a hybrid powertrain and a continuously variable transmission (CVT), along with a theoretical study of consumption that provides results in agreement with the experimental ones obtained and reported by the Car Maker.