Search results for "WAN"
showing 10 items of 854 documents
A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder
2012
Abstract Background β-Adrenoceptor agonists are effective in animal models of bladder dysfunction, and the human bladder primarily expresses the β3 receptor subtype. Objective To evaluate the efficacy and tolerability of the highly selective and potent β3-adrenoceptor agonist solabegron in a clinical proof-of-concept study in incontinent women with overactive bladder (OAB). Design, setting, and participants This was a randomized, double-blind trial in adult women with OAB (one or more 24-h incontinence episodes and eight or more average 24-h micturitions). Interventions Solabegron 50mg ( n =88), solabegron 125mg ( n =85), or placebo ( n =85)—all twice daily—were administered. Outcome measur…
Influence of nerve branch of origin and extracanalicular extension of the tumor on hearing after middle fossa removal of vestibular schwannoma
2007
Neither nerve branch of origin nor extracanalicular (up to 1 cm) extension of a vestibular schwannoma (VS) influence the postoperative hearing outcome in patients operated via a middle cranial fossa (MCF) approach.To test whether the nerve branch of tumor origin and an extracanalicular, up to 1 cm, tumor extension influences hearing outcome after MCF VS surgery.This was a retrospective case review of 50 patients with postoperative pure-tone audiogram (PTA) performed later than 90 days after surgery. Twenty patients had a superior vestibular nerve (SVN) tumor and 27 patients had an inferior vestibular nerve (IVN) tumor. In three patients the nerve branch of origin of the VS could not be uneq…
A Novel Method for Detecting APT Attacks by Using OODA Loop and Black Swan Theory
2018
Advanced Persistent Threat(APT) attacks are a major concern for the modern societal digital infrastructures due to their highly sophisticated nature. The purpose of these attacks varies from long period espionage in high level environment to causing maximal destruction for targeted cyber environment. Attackers are skilful and well funded by governments in many cases. Due to sophisticated methods it is highly important to study proper countermeasures to detect these attacks as early as possible. Current detection methods under-performs causing situations where an attack can continue months or even years in a targeted environment. We propose a novel method for analysing APT attacks through OO…
Les dynamiques du périurbain dijonnais entre 1990 et 1999
2009
Un étalement urbain accompagne désormais la croissance des villes, notamment les plus grandes. Principalement expliqué par un desserrement résidentiel, il est aussi la résultante des dynamiques de centralisation de l’emploi et de spécialisation des zones d’activité à l’intérieur des aires urbaines. L’exemple dijonnais met bien en lumière ce double mouvement qui affecte les communes de sa périphérie et contribue à accroître les mobilités. Urban sprawl arises from the growth of cities, especially of the biggest cities. This urban sprawl is accounted for mainly by residential clearing. It results also from the dynamics of centralization of employment and from specialization of activity zones i…
Logika algorytmów w świecie pracy ery technologicznej - nowe możliwości i nowe ograniczenia
2022
Uprawnienia kierownicze pracodawcy wynikające z przepisów prawa pracy są innej natury niż te kształtowane przez technologię, lokują one działanie kierownictwa pracodawcy w zupełnie innym obszarze niż technologia — w relacjach międzyludzkich, a nie w danych, w poleceniach, a nie w sygnałach, w odnoszeniu się do sposobów bycia jednostki, a nie do sprzężeń zwrotnych, do jej sumienności i staranności, a nie do nastawiania jej na wykorzystywanie. Kierownictwo technologiczne ma inne środki wyrazu, inną metodykę działania, inną skalę przymusu i porządku, jest inaczej zabezpieczane, nie zna granic, które stawia się kierownictwu normatywnemu. Technologia pozwala na zmianę paradygmatu kierownictwa dz…
World distribution of middle Jurassic ammonites (Upper Aalenian to Middle Bathonian): relationships between biodiversity and palaeogeography
2004
Abstract The break up of the Pangea takes place in the Jurassic; the palaeoceanographic consequences are the opening of seaways, particularly at the place of the future Atlantic and Indian oceanic areas. During the Toarcian, and from the late Aalenian to the middle Bathonian, the so-called “Hispanic corridor” (or “Atlantic seaway”) exists between the “western Tethys” and the “American Pacific border”, through the “Caribbean Tethys”. Two additional seaways which play as by-passes of the Pangea are proposed, one along the northern border of Laurasia (Boreal sea), and a second along the southern border of Gondwana (South Pacific Sea); however, if these two last could be effectively used for fa…
Typy kryminalistycznej analizy informacji
2022
Kryminalistyczna analiza informacji jest stosunkowo młodą, choć dynamicznie rozwijającą się dziedziną, wpływającą istotnie na proces wykrywczy oraz proces dowodzenia sądowego. Za najbardziej upowszechnioną na gruncie praktyki śledczej uznać można analizę kryminalną, jednak w literaturze wyróżnia się również analizę wywiadowczą oraz analizę dowodową, które nie mają jeszcze ugruntowanej pozycji. Ponadto, dodatkowym problemem jest brak jednolitego aparatu pojęciowego związanego z kryminalistyczną analizą informacji. Celem tego artykułu jest zaznajomienie Czytelnika z istotą poszczególnych typów analizy informacji oraz wyjaśnienie najistotniejszych pojęć na podstawie współczesnego dorobku nauki…
Hookworm-like eggs in children’s faecal samples from a rural area of Rwanda
2016
Background: Hookworm eggs identification and quantification is usually carried out by Kato-Katz method. However various structures present in the smear may be confused with eggs of such parasites. Objective: To document the presence of structures in Kato-Katz slides that could initially be misinterpreted as hookworm eggs. Method: 497 faecal samples were analysed by Kato-Katz technique, diphasic concentration technique, agar-plate coprocultive and larvae obtained were analysed by PCR and characterized by sequencing. Result: Hookworm-like eggs were found in 159 (32%) of the samples by Kato Katz, finally identified as Caenorhabditis elegans by PCR technique. Conclusion: The diagnosis of human …
Modeling suggests that oblique extension facilitates rifting and continental break-up
2012
[1] In many cases the initial stage of continental break-up was and is associated with oblique rifting. That includes break-up in the Southern and Equatorial Atlantic, separation from eastern and western Gondwana as well as many recent rift systems, like Gulf of California, Ethiopia Rift and Dead Sea fault. Using a simple analytic mechanical model and advanced numerical, thermomechanical modeling techniques we investigate the influence of oblique extension on the required tectonic force in a three-dimensional setting. While magmatic processes have been already suggested to affect rift evolution, we show that additional mechanisms emerge due to the three-dimensionality of an extensional syst…
TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens…
2019
Probiotic microorganisms are of great interest in clinical, livestock and aquaculture. Knowledge of the genomic basis of probiotic characteristics can be a useful tool to understand why some strains can be pathogenic while others are probiotic in the same species. An automatized workflow called TarSynFlow (Targeted Synteny Workflow) has been then developed to compare finished or draft bacterial genomes based on a set of proteins. When used to analyze the finished genome of the probiotic strain Pdp11 ofShewanella putrefaciensand genome drafts from seven known non-probiotic strains of the same species obtained in this work, 15 genes were found exclusive of Pdp11. Their presence was confirmed …