Search results for "WATER MAZE"

showing 3 items of 23 documents

Effects of lobeline on spatial learning in C57BL mice

2000

In the present study, the effect of lobeline on water maze performance in C57BL/6J mice have been evaluated. In the first experiment, subjects were 2-month old mice to which lobeline (3.5 and 7 mg/kg) had been administered SC along 5 days 15 min before daily training in the water maze. Results showed that lobeline did not have effects on the acquisition of the task. In the second experiment, effects of lobeline were compared in 2, 6 and 20-month old mice. In this experiment the drug was administered daily five days prior to the beginning of the task and during the five days of acquisition. Results indicated that 20-month old mice learned the spatial task more slowly than 2 and 6-month old m…

chemistry.chemical_compoundchemistryGeneral NeuroscienceAnesthesiaSpatial learningLobelineWater mazePsychologyC57bl 6jNeuroscience Research Communications
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Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding

2015

Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a high-fat diet (HFD) with an unbalanced n-6/n-3 PUFAs ratio on hippocampal function in adult rats. Furthermore, we explored the effects of perinatal HFD combined with exposure to HFD after weaning. Dams were fed a control diet (C, 12% of energy from lipids, n-6/n-3 PUFAs ratio: 5) or HFD (HF, 39% of energy from lipids, n-6/n-3 PUFAs ratio: 39) th…

medicine.medical_specialtyOffspringhippocampusEndocrinology Diabetes and MetabolismWeaningHippocampal formationBiologyDiet High-FatmemoryEndocrinologyPregnancyFatty Acids Omega-6Internal medicineLactation[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyFatty Acids Omega-3medicineAnimalsLactationWeaningwater mazeTaqMan low-density arrayRats WistarMaze LearningOmega 3 fatty acidBiological PsychiatrySpatial Memory2. Zero hungerchemistry.chemical_classificationPerinatal ExposureEndocrine and Autonomic Systemsomega-6 fatty acidomega-3 fatty acidfood and beveragesRatsPsychiatry and Mental healthEndocrinologymedicine.anatomical_structureAnimals NewbornchemistryPrenatal Exposure Delayed Effects[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Omega-6 fatty acidFemale[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]lipids (amino acids peptides and proteins)[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyPolyunsaturated fatty acid
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Water maze performance, exploratory activity, inhibitory avoidance and hippocampal plasticity in aged superior and inferior learners

2002

In 28- to 30-month-old rats, in vitro short-term and long-term potentiation (STP and LTP) were measured in area CA1 of the hippocampus in seven superior and seven inferior learners, that were selected from a pool of 40 rats based on water maze escape performance over a period of 9 days. The aim was to examine whether levels of STP and LTP could account for group differences in learning of water maze escape, spatial preference and wall (thigmotaxis)-avoidance and in short-term retention of an inhibitory avoidance task. There was no significant group difference in open-field exploration, i.e. the number of rearings. In contrast to expectation, the superior and inferior learners did not differ…

medicine.medical_specialtyThigmotaxisPreference learningGeneral NeuroscienceHippocampusLong-term potentiationWater mazeHippocampal formationAudiologyInhibitory postsynaptic potentialOpen fieldDevelopmental psychologynervous systemmedicinePsychologyEuropean Journal of Neuroscience
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