Search results for "WES"
showing 10 items of 1585 documents
Green Wrocław: Urban Narratives of Three Post-War Generations of Wrocław’s Inhabitants
2020
This study is an invitation to reflect on issues that fall within the area of collective memory, an area that awaits further in-depth analysis. More specifically, this article is a proposal of a broader study on cultural landscape and places of memory than that which is dominant in the sociological literature. In particular, I examine the relationship between the inhabitants of the Polish “Western Lands” and the material German heritage of the cities in which they happen to live. I mainly focus on the relation between socially constructed memory and greenery—a “negligible” part of the space of human life. As I demonstrate in the article, the “green” narrations about Wrocław created after Wo…
Globalización, valores sociales y choque de civilizaciones
2005
The thesis of the supposed clash of the Islamic and the western civilizations is, by far, the most diffused and debated of all the subjects and proposals dealt Huntington in his book <i>The Clash of Civilizations and the Remaking of World Order</i>, above all after the terrorist attacks of the September 11<sup>th</sup>. The results of the World Social Survey 2000-2001 directed by Inglehart, are used in the present article to test the thesis of the cultural differences in a wide sample of Western Christian and Islamic societies. The comparative analysis undertaken allows to conclude that the cultural differences between both group societies are quite important, althou…
In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis
2003
Several clinical trials have revealed that individuals who were given beta-carotene and vitamin A did not have a reduced risk of cancer compared to those given placebo; rather, vitamin A could actually have caused an adverse effect in the lungs of smokers [Omenn, G.S., Goodman, G.E., Thornquist, M.D., Balmes, J., Cullen, M.R., Glass, A., Keogh, J.P., Meyskens, F.L., Valanis, B., Williams, J.H., Barnhart, S. & Hammar, S. N. Engl. J. Med (1996) 334, 1150-1155; Hennekens, C.H., Buring, J.E., Manson, J.E., Stampfer, M., Rosner, B., Cook, N.R., Belanger, C., LaMotte, F., Gaziano, J.M., Ridker, P.M., Willet, W. & Peto, R. (1996) N. Engl. J. Med. 334, 1145-1149]. Using differential display techniq…
Analysis of cytochrome C oxidase subunits III and IV expression in developing rat brain
2004
Abstract Cytochrome c oxidase (COX) complex is built up with both nucleus- and mitochondrion-encoded subunits. Biogenesis and assembly of the complex thus requires fine cross-talk between the two compartments. In order to shed light on the regulation of nuclear–mitochondrial interactions, we studied the expression of COXIII (mitochondrion-encoded) and COXIV (nucleus-encoded) in adult rat tissues and rat developing brain. We found that the levels of COXIV protein and mRNA are not linearly related, thus suggesting a post-transcriptional mode of regulation. In agreement with this observation, we report the presence of a protein that specifically binds to the 3′-untranslated region of COXIV mRN…
Molecular basis of the functional distinction between Cln1 and Cln2 cyclins
2012
Cln1 and Cln2 are very similar but not identical cyclins. In this work, we tried to describe the molecular basis of the functional distinction between Cln1 and Cln2. We constructed chimeric cyclins containing different fragments of Cln1 and Cln2 and performed several functional analysis that make it possible to distinguish between Cln1 or Cln2. We identified that region between amino acids 225 and 299 of Cln2 is not only necessary but also sufficient to confer Cln2 specific functionality compared with Cln1. We also studied Cln1 and Cln2 subcellular localization identifying additional differences between them. Both cyclins are distributed between the nucleus and the cytoplasm, but Cln1 shows…
Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
2005
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved in APP endocytosis. Here, we show that the APP homolog APLP1 (amyloid precursor-like protein 1) influences APP shedding. In human embryonic kidney 293 cells expression of APLP1 strongly activated APP shedding by alpha-secretase and slightly reduced beta-secretase cleavage. As revealed by domain deletion analysis, the increase in APP shedding re…
Dendritic cells trigger tumor cell death by a nitric oxide-dependent mechanism.
2007
Abstract Dendritic cells (DCs) are well known for their capacity to induce adaptive antitumor immune response through Ag presentation and tumor-specific T cell activation. Recent findings reveal that besides this role, DCs may display additional antitumor effects. In this study, we provide evidence that LPS- or IFN-γ-activated rat bone marrow-derived dendritic cells (BMDCs) display killing properties against tumor cells. These cytotoxic BMDCs exhibit a mature DC phenotype, produce high amounts of IL-12, IL-6, and TNF-α, and retain their phagocytic properties. BMDC-mediated tumor cell killing requires cell-cell contact and depends on NO production, but not on perforin/granzyme or on death re…
Chińska aktywność na Bałkanach w XXI wieku i jej implikacje
2022
Celem artykułu jest szkicowe przedstawienie, na podstawie analiz i materiałów prasowych, wielosektorowej obecności Chin na Bałkanach i jej wpływu na sytuację ekonomiczną regionu. Bałkany są ważne dla mocarstw ze względu na położenie geopolityczne i geostrategiczne na skrzyżowaniu szlaków międzykontynentalnych. Chiny znacząco wpływają na ekonomikę poszczególnych państw region, wykorzystując dyplomację publiczną celem ograniczenia wpływów ze strony innych ważnych graczy: Unii Europejskiej, Rosji i USA. Autorka przedstawia hipotezę, że Chiny, tak jak USA pod koniec XX wieku, zmierzają do stworzenia sfery wpływów na Półwyspie Bałkańskim, w kontekście swoich interesów globalnych. Bałkany są post…
Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe
2021
Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA…
Hybridity Maintained, Reduced, Abolished and Redefined: The Czech Graphic Novel Alois Nebel (Jaroslav Rudiš, Jaromír 99, 2006) in Polish and German
2016
This study is devoted to comparative analysis of hybridity in Jaroslav Rudis’s and Jaromir Svejdik’s Graphic Novel Alois Nebel – the trilogy in book-form, 2006 (2011) – and the Polish and German translations. The basic forms of hybridity are intermedial (picture and text) hybridity, linguistic hybridity (given by elements of German, Russian, English, Polish and Slovak together with Czech main text), graphic hybridity (between Latin and Cyrillic script, printed and hand-written characters), and hybridity of discourse (interpersonal communication, telling, personal reflection, non-fiction text etc.). While the Polish text – privileged by translation between two West Slavic languages – maintai…