Search results for "WES"
showing 10 items of 1585 documents
Characterization of monoclonal antibodies generated against bovine and porcine prostacyclin synthase and quantitation of bovine prostacyclin synthase
1994
AbstractMonoclonal antibodies were raised against prostacyclin synthases purified from bovine and porcine aortae, respectively. Two monoclonal antibodies, RS1 and RS2, were purified and characterized. As shown by enzyme activity precipitation and Western blot analysis, in solubilized bovine and porcine aortae microsomes the monoclonal antibodies reacted only with prostacyclin synthase. The monoclonal antibody RS1 cross-reacts with partially purified prostacyclin synthase from human umbilical veins in an ELISA-based assay. None of the antibodies inhibited the enzyme activity. By combination of the monoclonal antibody RS2 with a polyclonal antibody we established an enzyme-linked immunosorben…
Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1
2003
Objectives: Serum is among the agents known to induce hypertrophy of cardiac myocytes, which occurs concomitant with an increase in AP-1-mediated transcription. We have examined if this effect correlates with changes in the relative abundance of particular AP-1 heterodimers, as their exact composition under these conditions is unknown. Furthermore, we obtained insight on the specific role of c-Fos from studying the induction of the glucose transporter GLUT1 by serum in fibroblasts. Methods: We characterised the AP-1 heterodimers expressed in neonatal cardiac myocytes by supershift electrophoretic mobility shift assay (EMSA) analysis. Quantitative changes in transcription were measured using…
Intraseasonal variations of June?September rainfall and upper-air circulation over Kenya
1996
In the Northern Summer, Kenya is located under the influence of the divergent Indian monsoon flow, and therefore is dry except for two separate areas: the coastal strip and the western regions. Analysis of daily rainfall data for June–September 1982 to 1988 has revealed that, although there are many distinct rainfall events between the two regions, an out-of-phase relationship is also evident, rain on the Coast being frequently accompanied by a drop in the precipitation over the Rift Valley area. It is shown that two types of wind forcing accompany these patterns. Alternating westerly and easterly anomalies at the 700 hPa level are associated with persistent wet and dry conditions (respecti…
Role of Indian fluxes in the intraseasonal 10-30 days variability of the African monsoon.
2018
12 pages; International audience; This study focused on the influence of Indian monsoon on the 10-30 days variability of the West African monsoon. One relies on the 500-300 hPa moisture fluxes calculated from specific wind and moisture fields from the ERAInterim reanalysis over the 1998-2008 period. These fluxes carry a signal of a spatio-temporal Rossby wave structure propagating westward from India. In the active phase of high convection of this wave, 500-300 hPa fluxes are Easterly. This high-tropospheric Rossby wave signal from the Indian monsoon area would modulate the dynamics over the Sahel.
Interaction between the West African Monsoon and the summer Mediterranean climate: An overview.
2013
15 pages; International audience; Although in the framework of the global climate research the Mediterranean climate variability andthe West African Monsoon (WAM) dynamics have been considered for a long time as “passive”systems, i.e., prone to the influence of large scale ocean and atmospheric variability, over the lastdecade many studies have been dedicated to the WAM-Mediterranean interaction and the active roleof these climate systems has been highlighted. This article presents the WAM-Mediterraneanteleconnection through an overview of the recent literature, describing the observational evidencesand the dynamical mechanisms underlying this climate teleconnection. The influence of the Me…
“Krokodil”—Revival of an Old Drug with New Problems
2012
In order to summarize current knowledge about the drug "Krokodil" a systematic review including a literature search of the databases PubMed, Embase, Scopus, and Google was conducted in December 2011. According to information acquired, "Krokodil" is a mixture of several substances and was first reported to have been used in Russia in 2003. The core agent of "Krokodil" is desomorphine, an opioid-analogue that can be easily and cheaply manufactured by oneself. Self-production results in a contaminated suspension that is injected intravenously. Due to its pharmacologic features, desomorphine shows a high potential to cause dependence. Against the background of first possible cases of "Krokodil"…
Description of Dryocosmus destefanii new species (Hymenoptera: Cynipidae: Cynipini) from Quercus suber L. in Italy
2018
A new species, Dryocosmus destefanii Cerasa & Melika n. sp. associated with a Cerris section oak, Quercus suber L., is described from Italy. Description, diagnosis, host associations and biology for the new species and an illustrated identification key to the Western Palaearctic Dryocosmus species are given. The description is supported by morphological and molecular data.
Mountain wild spaces in Portuguese northwest
2011
Fundação para a Ciência e a Tecnologia (FCT)
Predictability and prediction of lowest observed adverse effect levels in a structurally heterogeneous set of chemicals
2005
A database of chronic lowest observed adverse effect levels (LOAELs) for 234 compounds, previously compiled from different sources (Toxicology Letters79, 131-143 (1995)), was modelled using graph theoretical descriptors. This study reveals that data are not homogeneous. Only those data originating from the U.S. Environmental Protection Agency (EPA) reports could be well modelled by multilinear regression (MLR) and linear discriminant analysis (LDA). In contrast, data available from the specific procedures of the National Toxicology Program (NTP) database introduced noise and did not render good models either alone, or in combination with the EPA data.
Key processing precedes emotional categorization of Western music.
2005
To investigate whether key processing precedes the appraisal of valence in music, participants listened to pairs of clips of same or different valence, played either in the same key or one semitone apart. They judged whether the second clip expressed the same emotion as the first one. Our predictions were confirmed: the response times obtained were shorter when both clips were played in the same key than when they were played one semitone apart.