Search results for "WHO"

showing 10 items of 829 documents

Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107.

2014

ABSTRACT We report the draft genome sequence of Microbispora sp. strain ATCC-PTA-5024, a soil isolate that produces NAI-107, a new lantibiotic with the potential to treat life-threatening infections caused by multidrug-resistant Gram-positive pathogens. The draft genome of strain Microbispora sp. ATCC-PTA-5024 consists of 8,543,819 bp, with a 71.2% G+C content and 7,860 protein-coding genes.

Strain atccWhole genome sequencingStrain (chemistry)Microbispora sp.GeneticsProkaryotesLantibioticsBiologyMolecular BiologyGenomeGeneC contentMicrobiologyGenome announcements
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Stress-Strain Concept in Whole-Body Vibration

1986

The strain-stress concept defines stress. First of all, stress refers to vibration exposure (kind, intensity, and duration of vibration) and the additional stress factors that act upon man when exposed. Strain, on the other hand, means the effects of such stress, that is, the reaction (biodynamic, psychological, physiological, damaging) of the human being, taking into consideration the individual endogenous conditions (see Table 2).

Stress (mechanics)Vibrationbusiness.industryStress–strain curveWhole body vibrationStructural engineeringVibration exposurebusinessHuman beingMathematics
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The complete genome sequence of Lamium mild mosaic virus, a member of the genus Fabavirus

2013

Springer-Verlag Wien 2013 Abstract Lamium mild mosaic virus (LMMV) is the only one of the five members of the genus Fabavirus for which there are no nucleotide sequence data. In this study, the complete genome sequence of LMMV was determined and compared with the available complete genome sequences of other members of the genus Fabavirus. The genome was the largest of the genus but maintained the typical orga- nization, with RNA 1 of 6080 nucleotides (nt), RNA 2 of 4065 nt, and an unusually long 3 0 untranslated region in RNA 2 of 603 nt. Phylogenetic analysis of the amino acid sequences of the protease-polymerase (Pro-Pol) region and the two coat proteins confirmed that LMMV belongs to a d…

SubfamilyLMMVMolecular Sequence DataGenome ViralGenomeFabaviruBroad bean wilt virusViral ProteinsSpecies SpecificityGenusMosaic VirusesVirologySecoviridaeTobaccoComovirinaePhylogenyPlant DiseasesGeneticsWhole genome sequencingLamiaceaebiologyBase SequenceNucleic acid sequenceSettore AGR/12 - Patologia Vegetalefood and beveragesGeneral MedicineDNA-Directed RNA PolymerasesSequence Analysis DNAClassificationbiology.organism_classificationVirologyFabavirusRNA ViralCapsid ProteinsPeptide Hydrolases
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La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia

2021

Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…

Summary ― The work presents the results of the bio-archaeological analyzes carried out on human skeletal remains found in fourteen burials of Medieval chronology at the Archaeological Park of Valle dei Templi in Agrigentum (Sicily). The aim of the work was the acquisition of the information necessary for the reconstruction of the biological profile of each individual throught the determination of sex the estimate of the biological age at death the estimate of height and the evaluation of pathologies and markers of occupational stress through current anthropological diagnostic methodologies and techniques. Althought the poor state of conservation of some individuals has not allowed their whole anthropological characterization the investigations have highlighted the heterogeneity relating to the age groups and have allowed us to ascertain the presence of pathological alterations in subjects of mature age sometimes of unknown etiology such as DISH (Diffuse Idiopathic Hyperostosis). The sample size is not representative of the entire population but subsequent insights will provide a better understanding of the population dynamics of Medieval Agrigentum.Settore BIO/08 - Antropologia
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HNRNPR Variants that Impair Homeobox Gene Expression Drive Developmental Disorders in Humans

2019

The heterogeneous nuclear ribonucleoprotein (HNRNP) genes code for a set of RNA-binding proteins that function primarily in the spliceosome C complex. Pathogenic variants in these genes can drive neurodegeneration, through a mechanism involving excessive stress-granule formation, or developmental defects, through mechanisms that are not known. Here, we report four unrelated individuals who have truncating or missense variants in the same C-terminal region of hnRNPR and who have multisystem developmental defects including abnormalities of the brain and skeleton, dysmorphic facies, brachydactyly, seizures, and hypoplastic external genitalia. We further identified in the literature a fifth ind…

TBX1MaleSpliceosomeHeterogeneous nuclear ribonucleoproteinDevelopmental DisabilitiesRNA SplicingBiologyHeterogeneous-Nuclear Ribonucleoproteins/geneticsHeterogeneous-Nuclear RibonucleoproteinsArticleWhole Exome Sequencing03 medical and health sciences0302 clinical medicineExome SequencingGeneticsHumansGenes Homeobox/geneticsPreschoolHox geneChildGeneTranscription factorGenetics (clinical)RNA Splicing/genetics030304 developmental biologyGeneticsFibroblasts/metabolism0303 health sciencesHomeobox/geneticsGenes HomeoboxInfantFibroblastsOxidative StressPhenotypeGenesDevelopmental Disabilities/etiologyGene Expression RegulationChild PreschoolRNA splicingMutationHomeoboxFemale030217 neurology & neurosurgery
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Taste Perception Profiles Are Associated With Adherence to Empirically Derived Dietary Patterns Among Older Adults With Metabolic Syndrome

2021

OBJECTIVES: Understanding individual-level drivers of food intake is critical when personalizing dietary guidance. One likely driver is taste perception; yet, limited data relate perception of all 5 tastes (sweet, salt, sour, bitter, umami) to dietary patterns (DPs). Our aim was to determine whether a multivariable measure of taste perception, taste perception profiles, was associated with adherence to empirically derived DPs. METHODS: Participants were 367 community-dwelling adults with metabolic syndrome from PREDIMED-Plus, Valencia (55–75 years; 55% female). Six taste perception profiles were derived from 5 taste perception scores via a data-driven clustering approach: Low All (23%), Hig…

TasteNutrition and Dieteticsbusiness.industrymedia_common.quotation_subjectDietary PatternsPhysical activityMedicine (miscellaneous)medicine.diseaseWhole grainsPerceptionDiabetes mellitusmedicineProcessed meatMetabolic syndromeStudent researchbusinessFood Sciencemedia_commonClinical psychology
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Whole genome sequencing of the black grouse (Tetrao tetrix): reference guided assembly suggests faster-Z and MHC evolution

2014

Background The different regions of a genome do not evolve at the same rate. For example, comparative genomic studies have suggested that the sex chromosomes and the regions harbouring the immune defence genes in the Major Histocompatability Complex (MHC) may evolve faster than other genomic regions. The advent of the next generation sequencing technologies has made it possible to study which genomic regions are evolutionary liable to change and which are static, as well as enabling an increasing number of genome studies of non-model species. However, de novo sequencing of the whole genome of an organism remains non-trivial. In this study, we present the draft genome of the black grouse, wh…

Tetrao tetrixMaleGenome evolutionBiologyGenomePolymorphism Single NucleotideChromosomesBirdsEvolution MolecularMajor Histocompatibility ComplexGene densityGeneticsAnimalsGenetikGenome sizeRepetitive Sequences Nucleic AcidGeneticsComparative genomicsWhole genome sequencingteeriGenomeComputational BiologyHigh-Throughput Nucleotide SequencingMolecular Sequence AnnotationGenome projectGenomicsEvolutionary biologyReference genomeBiotechnologyResearch ArticleBMC Genomics
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La Media Education al Centro Tau. Dalla teoria alla pratica

2022

Il contributo illustra le attività di media education del Centro Tau di Palermo come approccio per la costruzione di una civic intentionality (Mihailidis and Thevenin 2013) nei giovani che frequentano questo centro di aggregazione giovanile collocato in una delle aree più colpite da disagio sociale della città di Palermo.

The contribution illustrates the media education activities of the Tau Centre of Palermo as an approach for the construction of a civic intentionality (Mihailidis and Thevenin 2013) in the young people who attend this youth centre located in one of the areas most affected by social hardship in the city of Palermo.Settore SPS/08 - Sociologia Dei Processi Culturali E Comunicativi
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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Non solo Platone. Il primato dell'oralità nel retore Alcidamante

2020

Il saggio è dedicato all’orazione Sugli autori dei discorsi scritti o sui sofisti, attribuita al retore Alcidamante, discepolo di Gorgia e attivo in Atene tra il 410 e il 365 a.C. Argomento dell’orazione è il serrato confronto tra due differenti modalità oratorie, l’autoschediazein (“parlare a braccio”) — cui Alcidamente accorda una netta superiorità — e il "gegrammena legein (“pronunciare discorsi scritti”). L’interesse di questo testo (databile con buona approssimazione intorno al 390 a. C) consiste essenzialmente nel rappresentare un punto di vista specificamente retorico sulla questione delle differenze tra scritto e parlato. Nonostante alcune significative convergenze con il ben più ce…

The essay focuses on the speech “Perì Sophiston” (Concerning Sophists) attributed to Alcidamas a rhetorician who was pupil of Gorgias and thought in Athens between 410 and 365 BC. In this speech Alcidamas stresses the superiority of extempore (though prepared) speeches over written one. The speech is particularly interesting because it represents the specifically rhetorical point of view on the issue of the differences between written and spoken word. The essay underlines the originality of Alcidamas (especially compared to Plato) and his interest also in the contemporary debate on the differences between written and spoken.Settore M-FIL/05 - Filosofia E Teoria Dei Linguaggi
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