Search results for "WIDE"
showing 10 items of 1235 documents
An Integrated Framework for Web Services Orchestration
2009
International audience; Currently, Web services give place to active research and this is due both to industrial and theoretical factors. On one hand, Web services are essential as the design model of applications dedicated to the electronic business. On the other hand, this model aims to become one of the major formalisms for the design of distributed and cooperative applications in an open environment (the Internet). In this article, the authors will focus on two features of Web services. The first one concerns the interaction problem: given the interaction protocol of a Web service described in BPEL, how to generate the appropriate client? Their approach is based on a formal semantics fo…
Dynamic, Behavior-Based User Profiling Using Semantic Web Technologies in a Big Data Context
2013
pp. 363-372; International audience; The success of shaping the e-society is crucially dependent on how well technology adapts to the needs of each single user. A thorough understanding of one's personality, interests, and social connections facilitate the integration of ICT solutions into one's everyday life. The MindMinings project aims to build an advanced user profile, based on the automatic processing of a user's navigation traces on the Web. Given the various needs underpinned by our goal (e.g. integration of heterogeneous sources and automatic content extraction), we have selected Semantic Web technologies for their capacity to deliver machine-processable information. Indeed, we have…
New loci associated with kidney function and chronic kidney disease
2010
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or…
Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder.
2010
For patients with borderline personality disorder (BPD), we previously reported an independent effect of the catechol-o-methyl-transferase (COMT) low-activity (Met(158)) allele and an interaction with the low-expression allele of the deletion/insertion (short/long or S/L, resp.) polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR). The purpose of the present study was to extend these findings to the tyrosine hydroxylase (TH) Val(81)Met single nucleotide polymorphism (SNP), the 5-HTTLPR S/L polymorphism incorporating the recently described functional A/G SNP within the long allele of the 5-HTTLPR (rs25531) as well as the variable number of tandem repeat (VNTR) polymorp…
U-search: a meta engine for creation of knowledge paths on the web
2010
The main tools used to find digital contents in the Web are search engines and directories but they are not presently able to understand the user specific needs and starting knowledge. This work presents "U-Search" a new meta engine that allows to create knowledge paths on the Web based on specific user requirements and knowledge levels. To this end, we consider different searcher categories such as a "basic searcher" who knows little about a topic and will look for more information, a "deep searcher" who will look for specific details on a topic that he/she already knows and a "wide searcher" who will look for expanding his/her knowledge domain with topics that are loosely related to the s…
A web search methodology for different user typologies
2009
Search engines and directories are the main tools used to find desired information into the ocean of digital contents that is the Web. However, they are not presently able to understand the user specific needs and starting knowledge because their inability to simulate the processes of human mind. Natural Language Processing, Folksonomy, Semantic Web and Serendipitous Surfing are some of the recent research fields towards understanding of human natural language and in general of real user needs. This work aims to add one step more to this evolution path by presenting a new search methodology that allows users to create new knowledge paths on the web based on their specific requirements. Thus…
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
2013
The author manuscript of this article is open access and is freely available online at PubMed Central
Informal learning through expertise mining in the social web
2012
The advent of Web 2.0, also called the Social Web, has changed the way people interact with the Web. Assisted by the technologies associated with this new trend, users now play a much more active role as content providers. This Web paradigm shift has also changed how companies operate and interact with their employees, partners and customers. The challenge for companies and research institutions is now to develop semi-automated tools for gathering usable and explicit knowledge from such content. With the aim of facilitating the achievement of such a challenge, in this work a platform architecture for informal learning, which is based on semantic technologies, is proposed. Such platform perm…
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk.
2020
Abstract Aims To investigate whether metabolic signature composed of multiple plasma metabolites can be used to characterize adherence and metabolic response to the Mediterranean diet and whether such a metabolic signature is associated with cardiovascular disease (CVD) risk. Methods and results Our primary study cohort included 1859 participants from the Spanish PREDIMED trial, and validation cohorts included 6868 participants from the US Nurses’ Health Studies I and II, and Health Professionals Follow-up Study (NHS/HPFS). Adherence to the Mediterranean diet was assessed using a validated Mediterranean Diet Adherence Screener (MEDAS), and plasma metabolome was profiled by liquid chromatogr…
Neuropsychology and anorexia nervosa. Cognitive and radiological findings
2012
Introduction: Research into neuropsychological impairments present in the patients suffering from anorexia nervosa (AN) has advanced considerably, in the past decades. It now provides neuropsychologists with a wide field of knowledge of the changes found in the cerebral and cognitive capabilities of these patients, as well as their reversible or static features, thereby yielding a characteristic profile of neuropsychological impairment in AN. Development: We present a review updated to December 2010 of the results delivered by studies of both morphological and cognitive changes, providing us with an updated theoretical and practical framework for conducting future research. Conclusions: The…