6533b86dfe1ef96bd12cabf3
RESEARCH PRODUCT
New loci associated with kidney function and chronic kidney disease
Susan CampbellMladen BobanSharon L.r. KardiaSandra WildeAbbas DehghanChristian FuchsbergerPeter KovacsRenate B. SchnabelGary C. CurhanWolfgang KoenigWei WangWei WangBarbara KolleritsTalin HarituniansEvadnie RampersaudPhilipp S. WildYongmei LiuMary F. FeitosaSarah H. WildIvana KolcicMatthias OldenMedea ImbodenMedea ImbodenTanja ZellerAlbert V. SmithStephen T. TurnerIgor RudanThomas MünzelFrancesco GiallauriaAnna KöttgenAnna KöttgenUwe VölkerElizabeth J. AtkinsonChrista MeisingerJeffrey MetterPaul M. RidkerFlorian KronenbergLyudmyla KedenkoAnita BrandstätterDorothea NitschCornelia M. Van DuijnH.-erich WichmannMichael A. ProvinceAlan F. WrightHarry CampbellBruce M. PsatyMan LiAlex ParkerToshiko TanakaToshiko TanakaJeffrey R. O'connelNicholas D. HastieJames F. WilsonReinhold E. SchmidtPeter P. PramstallerKarlhans EndlichFrank B. HuInga ProkopenkoAndrew D. JohnsonSunita BadolaOzren PolasekAfshin ParsaNicole Probst-henschNicole Probst-henschAlbert HofmanWilmar IglThomas LumleyAnke TönjesCosetta MinelliIngrid B. BoreckiMarilyn C. CornelisAndrew B. SingletonMichael G. ShlipakRainer RettigStefan BlankenbergQiong YangLina ZgagaThierry RochatVilmundur GudnasonMargherita CavalieriYurii S. AulchenkoIris M. HeidThor AspelundHeyo K. KroemerCaroline HaywardTatijana ZemunikAlan R. ShuldinerVeronique VitartWen Hong L. KaoMatthias NauckBen A. OostraHelena SchmidtMariza De AndradeThomas IlligStefan SchreiberJacqueline C. M. WittemanAlexander TeumerUlf GyllenstenEric BoerwinkleTennille S. LeakCristian PattaroMichael StumvollDavid EllinghausGhazal ZaboliArne SchillertTamara B. HarrisAaron IsaacsBraxton D. MitchellCarsten A. BögerIan H. De BoerDan E. ArkingKurt LohmanAndre FrankeFernando RivadeneiraGudny EiriksdottirReedik MägiXiaoyi GaoNicole L. GlazerAndré G. UitterlindenBernhard K. KrämerJosef CoreshCaroline S. FoxCaroline S. FoxBernhard PaulweberNorman KloppAndreas ZieglerJanine F. FelixÅSa JohanssonDaniel I. ChasmanMaksim StruchalinDavid S. SiscovickGuillaume ParéShamika KetkarShih-jen HwangLuigi FerrucciHenry VölzkeM. CarolazillikensLenore J. Launersubject
medicine.medical_specialtyGENOME-WIDE ASSOCIATION ; SERUM CREATININE ; PROTEIN ; GENE ; MUTATIONS ; VARIANTS ; POPULATION ; CANDIDATE ; HOMOLOG ; MEGALINPopulationRenal functionGenome-wide association studyBiologyKidneyurologic and male genital diseasesCohort Studieschemistry.chemical_compoundSDG 3 - Good Health and Well-beingRisk FactorsInternal medicineGenetic MarkermedicineGeneticsHumansCystatin CeducationCystatin C/geneticsddc:616Genetic Markers/geneticsCreatinineKidneyeducation.field_of_studyModels GeneticRisk Factorchronic kidney disease; loci; SNPCreatinine/bloodmedicine.diseaseDietEuropeKidney/*physiologyEndocrinologymedicine.anatomical_structurechemistryCystatin CRenal physiologyCreatininebiology.proteinKidney Failure ChronicKidney Failure Chronic/ethnology/*geneticsCohort StudieKidney diseaseHumanGenome-Wide Association StudyGlomerular Filtration Ratedescription
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney. © 2010 Nature America, Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-01 |