Search results for "WIDE"

showing 10 items of 1235 documents

Do graphical overviews facilitate or hinder comprehension in hypertext?

2009

Educational hypertexts usually include graphical overviews, conveying the structure of the text schematically with the aim of fostering comprehension. Despite the claims about their relevance, there is currently no consensus on the impact that hypertext overviews have on the reader's comprehension. In the present paper we have explored how hypertext overviews might affect comprehension with regard to (a) the time at which students read the overview and (b) the hypertext difficulty. The results from two eye-tracking studies revealed that reading a graphical overview at the beginning of the hypertext is related to an improvement in the participant's comprehension of quite difficult hypertexts…

Structure (mathematical logic)General Computer ScienceInstructional designComputer sciencemedia_common.quotation_subjectEducational technologyHypermediaEducationlaw.inventionWorld Wide WebComprehensionlawReading (process)ComputingMethodologies_DOCUMENTANDTEXTPROCESSINGRelevance (information retrieval)Hypertextmedia_commonComputers & Education

researchProduct

Modeling Static Aspects of Mobile Electronic Commerce Environments

2011

Mobile phones and other small and powerful portable devices have revolutionized personal communication and affected the lifestyles of the people in the industrialized world. Following credible estimates, in a few years there will be one billion of such portable devices. An emerging trend is the electronic commerce performed using mobile terminals, often called mobile commerce. Mobile commerce environments are characterized by high complexity, including myriads of technical and organizational aspects. This property makes it difficult to distinguish the more fundamental issues, structures, and concepts in mobile commerce from the hype. To capture the fundamental aspects of mobile commerce env…

World Wide WebKnowledge managementbusiness.industryMobile commerceInformation technologyBusiness modelbusinessUbiquitous commerce

researchProduct

IRIDE: Interdisciplinary research infrastructure based on dual electron linacs and lasers

2014

This paper describes the scientific aims and potentials as well as the preliminary technical design of RUDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of sci…

researchProduct

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…

AgingMultifactorial InheritanceBLOODEpigenetic clock05 Environmental SciencesbiomarkkeritGenome-wide association studyQH426-470Epigenesis Genetic/dk/atira/pure/core/keywords/icep0302 clinical medicineBiomarkers of agingGWASBiology (General)AdiposityGenetics11832 Microbiology and virology0303 health sciences318 Medical biotechnologyDNA methylation1184 Genetics developmental biology physiologygenomiikkaDna Methylation ; Epigenetic Clock ; Gwasddc:DNA-metylaatioINSIGHTSC-Reactive ProteinepigenetiikkaDNA methylationMENDELIAN RANDOMIZATION/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingEducational StatusICEPGenetic MarkersPROVIDESSUSCEPTIBILITY LOCIBioinformaticsQH301-705.5GenomicsBiology03 medical and health sciencesNHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumAGESDG 3 - Good Health and Well-beingPlasminogen Activator Inhibitor 1REGRESSIONGeneticsHumansEpigeneticsGeneMETAANALYSIS030304 developmental biologyGenome HumanResearchGenetics of DNA Methylation Consortium06 Biological SciencesLipid MetabolismHuman geneticsGenetic architectureImmunity InnateikääntyminenGenetic LociCpG Islands08 Information and Computing Sciences3111 BiomedicineENRICHMENTepigenetic clock030217 neurology & neurosurgeryBiomarkersGenome-Wide Association StudyGranulocytes

researchProduct

Does higher education protect against obesity? Evidence using Mendelian randomization

2017

Objectives. The aim of this explorative study was to examine the effect of education on obesity using Mendelian randomization. Methods. Participants (N = 2011) were from the on- going nationally representative Young Finns Study (YFS) that began in 1980 when six cohorts (aged 30, 33, 36, 39, 42 and 45 in 2007) were recruited. The average value of BMI (kg/m(2)) measurements in 2007 and 2011 and genetic information were linked to comprehensive register based information on the years of education in 2007. We first used a linear regression (Ordinary Least Squares, OLS) to estimate the relationship between education and BMI. To identify a causal relationship, we exploited Mendelian randomization …

AdultMale0301 basic medicinemedicine.medical_specialtyobesityschoolingEpidemiology515 PsychologyProtective factorBody Mass Index03 medical and health sciencesbody weightBMI0302 clinical medicineWaist–hip ratioInternal medicineLinear regressionMendelian randomizationmedicineHumans030212 general & internal medicineFinlandGenetic associationeducationbusiness.industryPublic Health Environmental and Occupational Healthta3141ylipainota3142Mendelian Randomization Analysista3121medicine.diseaseObesityConfidence interval030104 developmental biologyEndocrinologykoulutusOrdinary least squaresEducational StatuslihavuusFemalewaist-hip ratiobusinessGenome-Wide Association StudyDemographyPreventive Medicine

researchProduct

Metacommunication Patterns in Online Communities

2009

Published version of a chapter in the book: Online Communities and Social Computing. Also available from the publisher at http://dx.doi.org/10.1007/978-3-642-02774-1_26 This paper discusses about contemporary literature on computer-mediated metacommunication and observes the phenomenon in two online communities. The results contribute by identifying six general-level patterns of how metacommunication refers to primary communication in online communities. A task-oriented, user-administrated, community (Wikipedia in Finnish) involved a remarkable number of specialized metacommunication genres. In a centrally moderated discussion-oriented community (Patientslikeme), metacommunication was inter…

World Wide WebComputer scienceAd hoc communicationVDP::Social science: 200::Library and information science: 320::Information and communication systems: 321Computer-mediated communicationCommunity developmentOnline communityonline community metacommunication genre computer-mediated communication

researchProduct

Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex

2014

Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.

nt nucleotidePTM post-translational modificationNuA3 histone acetyltransferase complexChIP-on-chip chromatin immunoprecipitation with genome-wide location arraysBiologyArticleGeneral Biochemistry Genetics and Molecular BiologyChromatin remodelingHistonesHistone H3NuA3 nucleosomal acetyltransferase of histone H3Histone H1Histone H2APdp3TAP–MS strategyHistone codelcsh:QH301-705.5TAP tandem affinity purificationGeneticsRNAPII RNA polymerase IIHistone acetyltransferaseWCE whole cell extractSAGA Spt-Ada-Gcn acetyltransferaseWT wild-typeChromatinYeastCell biologyChIP-on-chiplcsh:Biology (General)Histone methyltransferasebiology.proteinHAT histone acetyltransferaseTSS transcription start siteFEBS Open Bio

researchProduct

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain

researchProduct

The computational complexity of the relative robust shortest path problem with interval data

2004

Abstract The paper deals with the relative robust shortest path problem in a directed arc weighted graph, where arc lengths are specified as intervals containing possible realizations of arc lengths. The complexity status of this problem has been unknown in the literature. We show that the problem is NP -hard.

Discrete mathematicsInformation Systems and ManagementGeneral Computer ScienceManagement Science and Operations ResearchIndustrial and Manufacturing EngineeringLongest path problemWidest path problemEuclidean shortest pathShortest Path Faster AlgorithmTheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITYModeling and SimulationShortest path problemK shortest path routingCanadian traveller problemDistanceMathematicsofComputing_DISCRETEMATHEMATICSMathematicsEuropean Journal of Operational Research

researchProduct

Google matrix analysis of worldwide football mercato

2018

[EN] The worldwide football transfer market is analyzed as a directed complex network: the football clubs are the network nodes and the directed edges are weighted by the total amount of money transferred from a club to another. The Google matrix description allows to treat every club independently of their richness and allows to measure for a given club the efficiency of player sales and player acquisitions. The PageRank algorithm, developed initially for the World Wide Web, naturally characterizes the ability of a club to import players. The CheiRank algorithm, also developed to analyze large scale directed complex networks, characterizes the ability of a club to export players. The analy…

PageRankCheiRankComputer scienceBig dataComplex networksPLSFootballlaw.inventionWorld Wide WebBig dataCheiRankPageRanklawInternet dataQCAGoogle matrixMarkov chainsGoogle matrixMarkov chainbusiness.industryWeb dataComputingMilieux_PERSONALCOMPUTINGConferenceComplex networkFootball transfer marketSEMbusinessProceedings of the 2nd International Conference on Advanced Research Methods and Analytics (CARMA 2018)

researchProduct