Search results for "WIN"
showing 10 items of 4669 documents
Quantification of atelectatic lung volumes in two different porcine models of ARDS.
2006
BACKGROUND: Cyclic recruitment during mechanical ventilation contributes to ventilator associated lung injury. Two different pathomechanisms in acute respiratory distress syndrome (ARDS) are currently discussed: alveolar collapse vs persistent flooding of small airways and alveoli. We compare two different ARDS animal models by computed tomography (CT) to describe different recruitment and derecruitment mechanisms at different airway pressures: (i) lavage-ARDS, favouring alveolar collapse by surfactant depletion; and (ii) oleic acid ARDS, favouring alveolar flooding by capillary leakage. METHODS: In 12 pigs [25 (1) kg], ARDS was randomly induced, either by saline lung lavage or oleic acid (…
Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Ves…
2013
The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.
Environmental drivers of breeding sites in blackfly species of medical and veterinary importance in eastern Spain
2021
Geographical distribution and abundance of the pupae of six blackfly species of medical and veterinary concern were studied in eastern Spain according to three different sets of explanatory variables including in-stream variables, both (i) abiotic (i.e., physicochemical) and (ii) biotic (i.e., richness and abundance of either taxonomically or ecologically close related taxa), as well as (iii) meteorological and landscape variables. The results showed specific habitat requirements for pupation in Simulium (Boophthora) erythrocephalum (De Geer, 1776) and Simulium (Wilhelmia) equinum (Linnaeus, 1758), two of the six species studied regarding elevation and temperature. While the rest of the spe…
Dynamic mean absolute error as new measure for assessing forecasting errors
2018
Abstract Accurate wind power forecast is essential for grid integration, system planning, and electricity trading in certain electricity markets. Therefore, analyzing prediction errors is a critical task that allows a comparison of prediction models and the selection of the most suitable model. In this work, the temporal error and absolute magnitude error are simultaneously considered to assess the forecast error. The trade-off between both types of errors is computed, analyzed, and interpreted. Moreover, a new index, the dynamic mean absolute error, DMAE, is defined to measure the prediction accuracy. This index accounts for both error components: temporal and absolute. Real cases of wind …
Elektrophysiologische Untersuchung zum Einsatz von Streptolysin O und Natrium-Hyaluronat zur Permeabilitätsmodulation der Membran des runden Fensters…
2003
Background: The round window membrane (RWM) acts like a barrier for topically applied substances into the middle ear preventing diffusion into the perilymphatic fluid compartment. Material and Method: In an animal model, modulation of the permeability of the RWM was attempted using Streptolysin-O (SLO) in various concentrations and sodium hyaluronate. Thereafter, the effect of intratympanically applied Lidocain 2% on hearing threshold measured by auditory brainstem response was tested for Lidocain 2 % and Lidocain 2 % in combination with SLO or sodium hyaluronate. Results: The results show that both, SLO and sodium hyaluronate, influence the effect of Lidocain 2 % on hearing thresholds as a…
New prospective in treatment of Parkinson's disease: Studies on permeation of ropinirole through buccal mucosa
2012
The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of Parkinson's disease, passes the buccal mucosa. Flux and permeability coefficient values suggested that the membrane does not appear a limiting step to the drug absorption. Nevertheless, an initial lag time is observed but the input rate can be modulated by permeation enhancement using limonene or by application of electric fields. Absorption improvement was accompanied by the …
Upgrading landfill gas using a high pressure water absorption process
2014
Abstract The upgrading of landfill gas (methane 54.2 ± 2.0%, carbon dioxide 42.1 ± 2.4% and nitrogen 3.7 ± 1.2%) was studied with a pilot-scale high pressure water absorption system consisting of absorption, desorption and gas drying units. The gas was upgraded in two phases and with two absorption columns operating in sequence in pressures up to 180 bar, and with initial pressures of 8 and 10 bar. This type of high pressure process, where water is used for increasing the gas pressure, does not need a separate compression unit to produce the gas pressure required by gas vehicles. Product gas with a methane contents ranging from 83.0% to 92.1% was achieved with differing process parameters, …
Plan S: challenges and opportunities in Spain
2019
Spain is one of the most active European countries in the open access (OA) movement. Although the gold route has scarcely been used, the green route has been intensively implemented through fulfilment of European and national mandates and the development of institutional policies. Plan S is becoming a disruptive element in the context of scientific communication, and Spain’s possible adherence to Plan S could imply technical challenges in journals and repositories, additional costs that are difficult to estimate, or refusal to accept the Plan on the part of researchers (based on the loss of freedom to choose the journal in which to publish). However, the implementation of Plan S in Spain wo…
X-rays from accretion shocks in classical T Tauri stars: 2D MHD modeling and the role of local absorption
2013
AbstractIn classical T Tauri stars (CTTS) strong shocks are formed where the accretion funnel impacts with the denser stellar chromosphere. Although current models of accretion provide a plausible global picture of this process, some fundamental aspects are still unclear: the observed X-ray luminosity in accretion shocks is order of magnitudes lower than predicted; the observed density and temperature structures of the hot post-shock region are puzzling and still unexplained by models.To address these issues we performed 2D MHD simulations describing an accretion stream impacting onto the chromosphere of a CTTS, exploring different configurations and strengths of the magnetic field. From th…
« After buying ...before consuming »: a study of accumulation behaviour through the example of red win e consumers
2017
The main objective of this research is to help better understand a transitory behaviour –halfway between wine buying and consuming –namely accumulation. Data is gathered among a sample of 415 consumers, living in the cities of Lyon and Dijon and quantitative analysis is conducted. Respondents were invited to provide informations about Red wine bottles and appellations ’number they own . Socio-demographic variables’ influence on accumulation behaviour is measured and accumulators typology is analyzed : three main profiles have emerged. They are characterized by red wine bottles’ number and appellations owned, age and city of residence.