Search results for "Walker"
showing 10 items of 30 documents
On the occurrence of strong vertical wind shear in the tropopause region: a 10-year ERA5 northern hemispheric study
2021
A climatology of the occurrence of strong wind shear in the upper troposphere–lower stratosphere (UTLS) is presented, which gives rise to defining a tropopause shear layer (TSL). Strong wind shear in the tropopause region is of interest because it can generate turbulence, which can lead to cross-tropopause mixing. The analysis is based on 10 years of daily northern hemispheric ECMWF ERA5 reanalysis data. The vertical extent of the region analyzed is limited to the altitudes from 1.5 km above the surface up to 25 km, to exclude the planetary boundary layer as well as strong wind shear in higher atmospheric layers like the mesosphere–lower thermosphere. A threshold value of St2=4×10-4s-2 of t…
In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots
2019
NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) activation has been linked to several chronic pathologies, including atherosclerosis, type-II diabetes, fibrosis, rheumatoid arthritis, and Alzheimer’s disease. Therefore, NLRP3 represents an appealing target for the development of innovative therapeutic approaches. A few companies are currently working on the discovery of selective modulators of NLRP3 inflammasome. Unfortunately, limited structural data are available for this target. To date, MCC950 represents one of the most promising noncovalent NLRP3 inhibitors. Recently, a possible region for the binding of MCC950 to the NLRP3 protein was described but no details were …
Congenital muscular dystrophy: from muscle to brain.
2016
Congenital muscular dystrophies (CMDs) are a wide group of muscular disorders that manifest with very early onset of muscular weakness, sometime associated to severe brain involvement. The histologic pattern of muscle anomalies is typical of dystrophic lesions but quite variable depending on the different stages and on the severity of the disorder. Recent classification of CMDs have been reported most of which based on the combination of clinical, biochemical, molecular and genetic findings, but genotype/phenotype correlation are in constant progression due to more diffuse utilization of the molecular analysis. In this article, the Authors report on CMDs belonging to the group of dystroglyc…
Atlantin ylityksiä : amerikkalaisen kirjallisuuden- ja kulttuurintutkimuksen navigointia 1965-1995
2011
Teoriat muuttuvat paitsi aikaa myös paikkaa myöten. Kirjassa tutkitaan eurooppalaisen, varsinkin ranskalaisen teorian Atlantin ylityksiä. Millaisiksi eräät keskeiset teoriaotteet muotoutuivat yhdysvaltalaisessa yliopistomaailmassa ja kohdatessaan uudet poliittiset ja kulttuuriset haasteet? Tämän muotoutumisen vaikutukset näkyvät vuorostaan muualla. Ajanjakso on 1965–1995. "Korkean teorian" nousu liittyi kielelliseen käänteeseen ja perustojen horjumiseen, ja sen erilaisten muotojen ja myös vastustamisen tarkastelu ulottuu kielen merkityksiä hajottavasta retorisuudesta valtarakenteiden marxilaiseen analyysiin, afrikkalaisamerikkalaiseen feminismiin ja "orientalismin" symboliseen tuottamiseen …
Interannual to interdecadal variability of winter and summer southern African rainfall, and their teleconnections
2016
This study examines for the first time the changing characteristics of summer and winter southern African rainfall and their teleconnections with large-scale climate through the dominant time scales of variability. As determined by wavelet analysis, the austral summer and winter rainfall indices exhibit three significant time scales of variability over the twentieth century: interdecadal (15–28 years), quasi-decadal (8–13 years), and interannual (2–8 years). Teleconnections with global sea surface temperature and atmospheric circulation anomalies are established here but are different for each time scale. Tropical/subtropical teleconnections emerge as the main driver of austral summer rainf…
Seasonality and atmospheric dynamics of the teleconnection between African rainfall and tropical sea-surface temperature: Atlantic vs. ENSO
2001
A 47-year record (1951-1997) of gridded data covering Africa south of the Sahara was used to document the spatial and seasonal patterns of the correlation between precipitation and sea-surface temperatures (SST) in key tropical areas, as depicted by the NIN O3, South Atlantic and North Atlantic indices. El Nino -Southern Oscillation (ENSO) is confirmed as playing a dominant part in northeastern, eastern and southern Africa. However, its impact is also found over the Sahel during the northern summer, and other parts of the Gulf of Guinea region outside this season, a hitherto poorly documented feature. Over these two areas, ENSO and Atlantic SST (predominantly South Atlantic) contribute to d…
From Random Walker to Vehicular Traffic: Motion on a Circle
2014
Driving of cars on a highway is a complex process which can be described by deterministic and stochastic forces. It leads to equations of motion with asymmetric interaction and dissipation as well as to new energy flow law already presented at previous TRAFFIC AND GRANULAR FLOW meetings. Here we consider a model, where motion of an asymmetric random walker on a ring with periodic boundary conditions takes place. It is related to driven systems with active particles, energy input and depot. This simple model can be further developed towards more complicated ones, describing vehicular or pedestrian traffic. Three particular cases are considered, starting with discrete coordinate and time, the…
The cosmological constant problem in codimension-two brane models
2005
We discuss the possibility of a dynamical solution to the cosmological constant problem in the contaxt of six-dimensional Einstein-Maxwell theory. A definite answer requires an understanding of the full bulk cosmology in the early universe, in which the bulk has time-dependent size and shape. We comment on the special properties of codimension two as compared to higher codimensions.
Adiabatic expansions for Dirac fields, renormalization, and anomalies
2018
11 pags.
Probing the creatable character of perturbed Friedmann-Robertson-Walker universes
2008
We discuss whether some perturbed Friedmann-Robertson-Walker (FRW) universes could be creatable, i. e., could have vanishing energy, linear momentum and angular momentum, as it could be expectable if the Universe arose as a quantum fluctuation. On account of previous results, the background is assumed to be either closed (with very small curvature) or flat. In the first case, fully arbitrary linear perturbations are considered; whereas in the flat case, it is assumed the existence of: (i) inflationary scalar perturbations, that is to say, Gaussian adiabatic scalar perturbations having an spectrum close to the Harrison-Zel'dovich one, and (ii) arbitrary tensor perturbations. We conclude that…