Search results for "Walker"

Effects of nucleotide binding to LmrA: A combined MAS-NMR and solution NMR study

2015

ABC transporters are fascinating examples of fine-tuned molecular machines that use the energy from ATP hydrolysis to translocate a multitude of substrates across biological membranes. While structural details have emerged on many members of this large protein superfamily, a number of functional details are still under debate. High resolution structures yield valuable insights into protein function, but it is the combination of structural, functional and dynamic insights that facilitates a complete understanding of the workings of their complex molecular mechanisms. NMR is a technique well-suited to investigate proteins in atomic resolution while taking their dynamic properties into account…

HPMA-LMA copolymer drug carriers in oncology: an in vivo PET study to assess the tumor line-specific polymer uptake and body distribution.

2013

Polymeric drug carriers aim to selectively target tumors in combination with protecting normal tissue. In this regard polymer structure and molecular weight are key factors considering organ distribution and tumor accumulation of the polymeric drug delivery system. Four different HPMA based copolymer structures (random as well as block copolymers with lauryl methacrylate as hydrophobic block) varying in molecular weight, size and resulting architecture were analyzed in two different tumor models (AT1 prostate carcinoma and Walker-256 mammary carcinoma) in vivo. Polymers were labeled with (18)F and organ/tumor uptake was followed by μPET imaging and ex vivo biodistribution. Vascular permeabi…

Sex reversal from functional disomy of Xp: Prenatal and post-mortem findings.

2008

Translocations involving the short arms of the X and Y chromosomes are uncommon and are often associated with anomalies in gonadal development. Segmental duplications of the X chromosome interfere with the formation of the testis in patients with a 46,XY karyotype. The gene products located within the duplicated segment, when present in double dose, may affect on male sex development. We report on a fetus with karyotype 46,XY,der (14)t(X;14) (p10;p10)dn. Attached to chromosome 14 is the entire short arm of the X chromosome. Therefore, the fetus is affected with a disomy of Xp, resulting in complete male to female sex reversal, as well as other structural defects. To the best of our knowledg…

Stochastic reconstruction of sandstones

2000

A simulated annealing algorithm is employed to generate a stochastic model for a Berea and a Fontainebleau sandstone with prescribed two-point probability function, lineal path function, and ``pore size'' distribution function, respectively. We find that the temperature decrease of the annealing has to be rather quick to yield isotropic and percolating configurations. A comparison of simple morphological quantities indicates good agreement between the reconstructions and the original sandstones. Also, the mean survival time of a random walker in the pore space is reproduced with good accuracy. However, a more detailed investigation by means of local porosity theory shows that there may be s…

Nitric oxide inhibits the ATPase activity of the chaperone-like AAA+ ATPase CDC48, a target for S-nitrosylation in cryptogein signalling in tobacco c…

2012

NO has important physiological functions in plants, including the adaptative response to pathogen attack. We previously demonstrated that cryptogein, an elicitor of defence reaction produced by the oomycete Phytophthora cryptogea , triggers NO synthesis in tobacco. To decipher the role of NO in tobacco cells elicited by cryptogein, in the present study we performed a proteomic approach in order to identify proteins undergoing S-nitrosylation. We provided evidence that cryptogein induced the S-nitrosylation of several proteins and identified 11 candidates, including CDC48 (cell division cycle 48), a member of the AAA+ ATPase (ATPase associated with various cellular activities) family. In vit…

Using anatomic and metabolic imaging in stereotactic radio neuro-surgery treatments

2016

Diffusive thermal dynamics for the spin-S Ising ferromagnet

2008

We introduce an alternative thermal diffusive dynamics for the spin-S Ising ferromagnet realized by means of a random walker. The latter hops across the sites of the lattice and flips the relevant spins according to a probability depending on both the local magnetic arrangement and the temperature. The random walker, intended to model a diffusing excitation, interacts with the lattice so that it is biased towards those sites where it can achieve an energy gain. In order to adapt our algorithm to systems made up of arbitrary spins, some non trivial generalizations are implied. In particular, we will apply the new dynamics to two-dimensional spin-1/2 and spin-1 systems analyzing their relaxat…

The imprints of the Great Attractor and the Virgo cluster on the microwave background

1993

A fully non-linear model based on the Tolman-Bondi solution of the Einstein equations is used to describe the Great Attractor and the Virgo cluster. The background is a Friedmann-Robertson-Walker universe, and the inhomogeneity develops from physically motivated initial profiles of the energy density and the peculiar velocity. Accurate numerical integrations of the field equations of the null geodesics are carried out, and thus the angular temperature distribution of the microwave background produced by the chosen overdensities is found. The observer is located in the Local Group. The quadrupole Q produced by each overdensity is computed and divided into two parts: the relativistic Doppler …

A dynamical systems study of the inhomogeneous Lambda-CDM model

2010

We consider spherically symmetric inhomogeneous dust models with a positive cosmological constant, $\Lambda$, given by the Lemaitre-Tolman-Bondi metric. These configurations provide a simple but useful generalization of the Lambda-CDM model describing cold dark matter (CDM) and a Lambda term, which seems to fit current cosmological observations. The dynamics of these models can be fully described by scalar evolution equations that can be given in the form of a proper dynamical system associated with a 4-dimensional phase space whose critical points and invariant subspaces are examined and classified. The phase space evolution of various configurations is studied in detail by means of two 2-…

Adiabatic regularization with a Yukawa interaction

2017

We extend the adiabatic regularization method for an expanding universe to include the Yukawa interaction between quantized Dirac fermions and a homogeneous background scalar field. We give explicit expressions for the renormalized expectation values of the stress-energy tensor $\langle T_{\mu\nu} \rangle$ and the bilinear $\langle \bar\psi\psi\rangle$ in a spatially flat FLRW spacetime. These are basic ingredients in the semiclassical field equations of fermionic matter in curved spacetime interacting with a background scalar field. The ultraviolet subtracting terms of the adiabatic regularization can be naturally interpreted as coming from appropriate counterterms of the background fields…