Search results for "Wester"

A differential role of CREB phosphorylation in cAMP-inducible gene expression in the rat pineal

2000

In the rat pineal gland cAMP mediates nocturnal induction of the enzyme arylalkylamine N-acetyltransferase (AA-NAT) as well as of transcription factors such as inducible cAMP early repressor (ICER), Fos-related antigen-2 (Fra-2) and JunB. Cyclic AMP stimulates the phosphorylation of the DNA binding protein cAMP response element binding protein (CREB). While cAMP-induced CREB phosphorylation appears to be a prerequisite for AA-NAT and ICER gene expression, it is not known whether CREB phosphorylation accounts for the full cAMP response of the two genes. Furthermore, the significance of CREB phosphorylation in cAMP-activated Fra-2 and JunB transcription is unknown. In the present in vitro stu…

Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid

2004

E-selectin mediated tumor cell adhesion plays an important role in metastasis. Here we show that ionizing radiation (IR) induces E-selectin gene and protein expression in human endothelial cells at therapeutically relevant dose level. E-selectin expression is accompanied by an increase in the adhesion of human colon carcinoma cells to primary human umbilical vein endothelial cells (HUVEC). The HMG-CoA reductase inhibitor lovastatin impairs IR-stimulated E-selectin expression as analyzed at the level of the protein, mRNA and promoter. Inactivation of Rho GTPases either by use of Clostridium difficile toxin A or by co-expression of dominant-negative Rho blocked IR-induced E-selectin gene indu…

Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice

2007

Abstract Protection against Leishmania major in resistant C57BL/6 mice is mediated by Th1 cells, whereas susceptibility in BALB/c mice is the result of Th2 development. IL-12 release by L. major-infected dendritic cells (DC) is critically involved in differentiation of Th1 cells. Previously, we reported that strain differences in the production of DC-derived factors, e.g., IL-1αβ, are in part responsible for disparate disease outcome. In the present study, we analyzed the release of IL-12 from DC in more detail. Stimulated DC from C57BL/6 and BALB/c mice released comparable amounts of IL-12p40 and p70. In the absence of IL-4, BALB/c DC produced significantly more IL-12p40 than C57BL/6 DC. D…

Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels

2011

10 pages, 5 figures. 21779322[PubMed] PMCID: PMC3136927

ROUTES OF HIV-2 TRANSMISSION IN WESTERN EUROPE

1987

Proteomic profiling of Trastuzumab (Herceptin(R))-sensitive and -resistant SKBR-3 breast cancer cells.

2013

BACKGROUND: The Human Epidermal Growth Factor Receptor 2 (HER-2), overexpressed in 25-30% of breast carcinomas (BC), is the therapeutic target for trastuzumab, a recombinant humanized monoclonal antibody. The initial response to trastuzumab is often followed by drug-insensitivity within one year. Several hypotheses have been raised to explain this event, but the mechanisms behind the responses to trastuzumab are still unclear. Aim: To study the effects of short and prolonged trastuzumab treatment on the proteomic profiles of HER-2-overexpressing SKBR-3 BC cells. MATERIALS AND METHODS: Cells were treated with trastuzumab to obtain sensitive and resistant clones. The drug effects were evaluat…

First Record of Eurasian Spoonbills Platalea leucorodia feeding on Branchiopoda in a temporary wetland

2020

The diet of the Eurasian Spoonbill Platalea leucorodia is poorly documented with only the most common prey groups known, namely small fishes, amphibians, reptiles, crustaceans, molluscs, worms, leeches and plant material. Here, the first observations of three small crustaceans, Branchiopoda Triops cancriformis (Notostraca), Chirocephalus diaphanus (Anostraca), and Cyzicus tetracerus (Spinicaudata) are documented as prey of the Eurasian Spoonbill in a temporary wetland near the San Teodoro salt pan (Marsala, western Sicily). These observations provide a new insight into the foraging ecology of the species, showing its extreme opportunism in targeting small prey when feeding in a temporary we…

Biocénoses à triopsidés(Crustacea, Branchiopoda) du Permien du bassin de Lodève (France)

1997

Resume Nous decrivons les triopsides (Crustacea, Branchiopoda) qui abondent dans les facies “saxoniens” de la Formation du Salagou du bassin de Lodeve date “Thuringien” ou “Saxonien” selon les auteurs. A partir de milliers de debris de carapaces, d'axes thoraco-abdominaux et plus rarement a partir d'animaux entiers, nous avons identifie et decrit deux especes nouvelles: Triops cancriformis permiensis nov. ssp. et Lepidurus occitaniacus nov. sp., morphologiquement proches d' especes actuelles. En se basant sur les preferences ecologiques des triopsides actuels et les caracteristiques sedimentologiques de leur milieu de vie au Permien, nous avons confirme l'existence d'etendues d'eau, peu pro…

Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance.

2000

TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma. Single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA were used to establish two TP53 mutations (7.4%): a point mutation and a 63-bp duplication. Amplification of the MDM2 gene was observed in two tumors (7.4%) by means of Southern-blot analysis, one of them also carrying the TP53 point mutation. Immunohis…

Getting Adapted? A Comparative Study of Qualified Turkish Return Migrants from Germany and the USA

2017

When we consider the international migration history of Turkey, we see the key position of the immigration of worker migrants to Germany that has been going on since the 1960s. Due to the waves of migration from Turkey to Europe, and especially to Germany, Turks now form one of the largest minority groups living in Western Europe who have migrated from outside of the European Union (EU) region (Sirkeci 2002: 9). As a consequence, beginning from the first period of migration, Turkish migration to Germany has been a subject that social scientists have intensively analyzed. However, most studies have focused on guest workers and there have been a limited number of studies looking at the case o…