Search results for "XB"

Structure and the metal-support interaction of the Au/Mn oxide catalysts

2010

Gold catalysts with loading 1 and 10 wt % were-prepared by deposition precipitation method with urea over mesoporous manganese oxide, obtained through a surfactant-assisted procedure by using cetyltrimethylammonium bromide (CTAB), followed by treatment with sulphuric acid. For comparison, Au(10 wt %) was also deposited over commercial CeO2 and SiO2 supports. The materials were characterized by XRD and EXAFS at the Mn K and Au L-III edges and XPS. Moreover, the analyses were performed on the samples treated under 1%CO/He, at 250 degrees C for 90 min. The structural and surface results of the as prepared manganese oxide confirmed the formation of gamma-MnO2 along with some amorphous Mn3O4 upo…

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

2017

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) partici…

Prognostic value of SOX2 expression in neuroblastoma.

2010

SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma

2020

Background The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression. Material and Methods Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman’s correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions. Results SOX2 and BCL-2 expression w…

Chandra Observation of the Dipping Source XB 1254-690

2006

We present the results of a 53 ks long Chandra observation of the dipping source XB 1254--690. During the observation neither bursts or dips were observed. From the zero-order image we estimated the precise X-ray coordinates of the source with a 90% uncertainty of 0.6\arcsec. Since the lightcurve did not show any significant variability, we extracted the spectrum corresponding to the whole observation. We confirmed the presence of the \ion{Fe}{xxvi} K$_\alpha$ absorption lines with a larger accuracy with respect to the previous XMM EPIC pn observation. Assuming that the line width were due to a bulk motion or a turbulence associated to the coronal activity, we estimate that the lines were p…

The iron K-shell features of MXB 1728-34 from a simultaneous Chandra-RXTE observation

2005

We report on a simultaneous Chandra and RossiXTE observation of the low-mass X-ray binary atoll bursting source MXB 1728-34 performed on 2002 March 3-5. We fit the 1.2-35 keV continuum spectrum with a blackbody plus a Comptonized component. Large residuals at 6-10 keV can be fitted by a broad (FWHM ~ 2 keV) Gaussian emission line or, alternatively, by two absorption edges associated with lowly ionized iron and Fe XXV/XXVI at ~7.1 keV and ~9 keV, respectively. In this interpretation, we find no evidence of broad, or narrow, emission lines between 6 and 7 keV. We test our alternative modelling of the iron K shell region by reanalysing a previous BeppoSAX observation of MXB 1728-34, finding a …

Broadband spectral analysis of MXB 1659−298 in its soft and hard state

2018

The X-ray transient eclipsing source MXB 1659-298 went into outburst in 1999 and 2015. During these two outbursts the source was observed by XMM-Newton, nuSTAR, and Swift/XRT. Using these observations, we studied the broadband spectrum of the source to constrain the continuum components and to verify whether it had a reflection component, as is observed in other X-ray eclipsing transient sources. We combined the available spectra to study the soft and hard state of the source in the 0.45-55 keV energy range. We report a reflection component in the soft and hard state. The direct emission in the soft state can be modeled with a thermal component originating from the inner accretion disk plus…

Chandra Observation of the Persistent Emission from the Dipping Source XB 1916-053

2006

We present the results of a 50 ks long Chandra observation of the dipping source XB 1916-053. During the observation two X-ray bursts occurred and the dips were not present at each orbital period. From the zero-order image we estimate the precise X-ray coordinates of the source with a 90% uncertainty of 0.6''. In this work we focus on the spectral study of discrete absorption features, during the persistent emission, using the High Energy Transmission Grating Spectrometer on board the Chandra satellite. We detect, for the first time in the 1st-order spectra of XB 1916-053, absorption lines associated to Ne X, Mg XII, Si XIV, and S XVI, and confirm the presence of the Fe XXV and Fe XXVI abso…

Gata4 Blocks Somatic Cell Reprogramming By Directly Repressing Nanog

2012

Abstract Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by ectopic expression of the four factors Oct4, Klf4, Sox2, and Myc. Here, we investigated the role of Gata4 in the reprogramming process and present evidence for a negative role of this family of transcription factors in the induction of pluripotency. Coexpression of Gata4 with Oct4, Klf4, and Sox2 with or without Myc in mouse embryonic fibroblasts greatly impaired reprogramming and endogenous Nanog expression. The lack of Nanog upregulation was associated with a blockade in the transition from the initiation phase of reprogramming to the full pluripotent state characteristic of iPS cells. Addition of Nanog …

Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2

2013

Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor with highly undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. The objectives of this study were (i) to characterize CSCs from ex vivo ATC specimens by investigating the expression of several pluripotent stem cell markers, and (ii) to evaluate in vitro drug resistance modifications after specific CSC transcription factor switch-off.In ex vivo experiments, eight formalin-fixed, paraffin-embedded ATC specimens were analyzed by reverse-transcription and real-time quantitative PCR and immunohistochemistry. In in vitro experiments using ATC SW1736 cells, the…