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RESEARCH PRODUCT

SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma

Brunno Santos De Freitas SilvaKaique Leite De LimaAnna Carolina De OliveiraAline Carvalho BatistaLorena Rosa SilvaAna Cláudia Dezzen-gomideAmanda Cristina Ferreira Dos SantosFernanda Paula Yamamoto-silva

subject

Pathologymedicine.medical_specialtyScoring systemOdontogenic TumorsBiologyAmeloblastoma03 medical and health sciences0302 clinical medicineSOX2stomatognathic systemmedicineHumansKeratocystAmeloblastomaGeneral DentistryOral Medicine and PathologyResearchSOXB1 Transcription Factors030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]OdontogenicOtorhinolaryngologyProto-Oncogene Proteins c-bcl-2UNESCO::CIENCIAS MÉDICASembryonic structuresOdontogenic CystsImmunohistochemistrySurgeryFull thicknessmedicine.symptomImmunostaining

description

Background The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression. Material and Methods Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman’s correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions. Results SOX2 and BCL-2 expression was observed in all specimens of OKC in the full thickness of the epithelium lining. SOX2 immunostaining was higher in OKC, in comparison with AB samples (P<0.05). BCL-2 immunostaining between OKC and AB was not statistically significant. There was no significant correlation between SOX2 and BCL-2 in OKC and AB specimens. Conclusions SOX2 and BCL-2 expressions in OKC may suggest their relationship with the biological behavior of this lesion, and the higher expression of SOX2 might be an upstream influence on the Hh signaling pathway. Key words:Odontogenic keratocyst; Ameloblastoma; Odontogenic tumor; SOX2; BCL-2.

yearjournalcountryeditionlanguage
2020-01-01Medicina Oral, Patología Oral y Cirugía Bucal
10.4317/medoral.23348http://europepmc.org/articles/PMC7103439