Search results for "XB"
showing 10 items of 78 documents
The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway.
2013
Cutaneous melanoma is the fastest increasing cancer worldwide. Although several molecular abnormalities have been associated with melanoma progression, the underlying mechanisms are still largely unknown and few targeted therapies are under evaluation. Here we show that the HOXB7/PBX2 dimer acts as a positive transcriptional regulator of the oncogenic microRNA-221 and -222. In addition, demonstrating c-FOS as a direct target of miR-221&222, we identify a HOXB7/PBX2→miR-221&222 →c-FOS regulatory link, whereby the abrogation of functional HOXB7/PBX2 dimers leads to reduced miR-221&222 transcription and elevated c-FOS expression with consequent cell death. Taking advantage of the treatment wit…
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells
2013
In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…
A possible solution of the puzzling variation of the orbital period of MXB 1659-298
2017
MXB 1659-298 is a transient neutron star Low-Mass X-ray binary system that shows eclipses with a periodicity of 7.1 hr. The source went to outburst in August 2015 after 14 years of quiescence. We investigate the orbital properties of this source with a baseline of 40 years obtained combining the eight eclipse arrival times present in literature with 51 eclipse arrival times collected during the last two outbursts. A quadratic ephemeris does not fit the delays associated with the eclipse arrival times and the addition of a sinusoidal term with a period of $2.31 \pm 0.02$ yr is required. We infer a binary orbital period of $P=7.1161099(3)$ hr and an orbital period derivative of $\dot{P}=-8.5(…
Invasive vascular plant species of oxbow lakes in south-western Poland
2015
Abstract Natural water reservoirs are very valuable floristic sites in south-western Poland. Among them, the most important for the preservation of biodiversity of flora are oxbow lakes. The long-term process of human pressure on habitats of this type caused disturbances of their biological balance. Changes in the water regime, industrial development and chemisation of agriculture, especially in the period of the last two hundred years, led to systematic disappearances of localities of many plant species connected with rare habitats and also to the appearance of numerous invasive plant species. They are: Azolla filiculoides, Echinocystis lobata, Erechtites hieraciifolia, Impatiens glandulif…
XBRL
2007
This paper describes the main contributions in relation with the develop of an XBRL (Extensible Business Reporting Language) taxonomy proposed by the PRISMA research group at University UNAB. This taxonomy has been developed for public institutions in Colombia. This taxonomy is based on the information exchange of financial information. It is also described the creation of a wiki system which includes real information of existing XBRL projects in the world and the creation of a demostration center of XBR reports.
Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
2012
PMCID: PMC3494587
OP0204 Autophagy and Unfolded Protein Response: A Fine Balance that can Influence the Pathogenesis of Ankylosing Spondylitis and Inflammatory Bowel D…
2015
Background We have shown an increase in the unfolded protein response (UPR) with decreased ERAP1 or ERAP2 function in an in vitro system. Similarly UPR has been demonstrated to correlate with onset of disease in the HLA-B27 rat model. UPR has been difficult to demonstrate in the gut of AS patients but autophagy is upregulated. ERAP2 is associated with both AS and inflammatory bowel disease (IBD). Objectives Here we explore the moderating effect of autophagy on UPR. Specifically we study the impact of suppressing autophagy on UPR. Methods Lamina Propria Mononuclear cells (LPMC) were isolated from terminal ileal biopsies of 10 AS patients. Autophagy was suppressed with 2 agents anisomycin and…
Sähköisen taloushallinnon kehityksen merkitys tilintarkastuksessa
2016
Tutkimuksessa analysoidaan Suomessa tapahtunutta muutosta tilintarkastustyön painopisteissä taloushallinnon digitalisoitumisen myötä. Tutkimuksen teoriana toimii agenttiteoria ja tilintarkastusta koskeva ajantasainen lainsäädäntö yhdessä tilintarkastusta ohjaavien normien, hyvän tilintarkastustavan ja kansainvälisten standardien kanssa. Vaikka taloushallinnon toimintaympäristössä voidaankin nähdä radikaali muutos, ei tilintarkastajan työ ole kohdannut suuria muutoksia viimeisen kuudentoista vuoden aikana. Kun tarkastellaan tilintarkastusta käytännön työn, tilintarkastusta säätelevän lainsäädännön näkökulmasta, huomataan tilintarkastustyön pysyneen verrattain samanlaisena. Käytännön tilintar…
Rumicetum palustris (TIMÁR 1950) W. FISCHER 1978, new plant community from Bidentetea tripartiti R. Tx., LOHM. ET Prsg 1950 class in SW Poland
2016
Natural water reservoirs are very valuable floristic sites in Poland. Among them, the most important for preservation of biodiversity of plant communities are lakes, rivers, oxbow lakes and fishponds. The long-term process of human pressure on habitats of this type caused disturbance to their biological balance. Changes in the water regime, industrial development and chemisation of agriculture, especially in the period of last two hundred years, led to systematic disappearance of localities of many plant communities. Rumicetum palustris (Timár 1950) W. Fischer 1978, of Bidentetea tripartiti R. Tx., Lohm. et Prsg 1950 class, has been described for the first time in Hungary and Germany. This …
A Novel Halogen Bond Acceptor : 1-(4-Pyridyl)-4-Thiopyridine (PTP) Zwitterion
2020
Sulfur is a widely used halogen bond (XB) acceptor, but only a limited number of neutral XB acceptors with bifurcated sp3-S sites have been reported. In this work a new bidentate XB acceptor, 1-(4-pyridyl)-4-thiopyridine (PTP), which combines sp3-S and sp2-N acceptor sites, is introduced. Three halogen bonded cocrystals were obtained by using 1,4-diiodobenzene (DIB), 1,4-diiodotetrafluorobenzene (DIFB), and iodopentafluorobenzene (IPFB) as XB donors and PTP as acceptor. The structures of the cocrystals showed some XB selectivity between the S and N donors in PTP. However, the limited contribution of XB to the overall molecular packing in these three cocrystals and the results from DSC measu…