Search results for "XL"

Bcl-2, Bcl-xl, and pp32/PHAPI in resected non-small-cell lung cancer patients

2009

Einleitung: Fur viele Tumorarten ist der Einfluss des Apoptosesignalweges auf die Prognose der Tumorerkrankung beschrieben worden. So konnte fur die antiapoptotischen Proteine wie Bcl-2 und Bcl-xL gezeigt werden, dass sie den mitochondrialen Selbstzerstorungsmechanismus der Zellen herunterregulieren konnen. Fur nicht-kleinzellige Lungenkarzinomen (NSCLC) hingegen existieren widerspruchliche Angaben in der wissenschaftlichen Literatur in Bezug auf die prognostische Wertigkeit apoptotischer und insbesondere antiapoptotischer Faktoren. Ein weiterer wichtiger Faktor im genannten Mechanismus, welches NSCLC fur apoptotische Stimuli sensibilisieren soll, ist das Protein pp32/PHAPI. Fur bereits che…

Eleonora Chiavetta (a cura di), The Language of Autobiography. Discourses of Gender,Class and Ethnicity, XL edizioni, Roma, 2007

2007

Recensione

Directional Shuttling of a Stimuli-Responsive Cone-Like Macrocycle on a Single-State Symmetric Dumbbell Axle

2018

Rotaxane-based molecular shuttles are often operated using low-symmetry axles and changing the states of the binding stations. A molecular shuttle capable of directional shuttling of an acid-responsive cone-like macrocycle on a single-state symmetric dumbbell axle is now presented. The axle contains three binding stations: one symmetric di(quaternary ammonium) station and two nonsymmetric phenyl triazole stations arranged in opposite orientations. Upon addition of an acid, the protonated macrocycle shuttles from the di(quaternary ammonium) station to the phenyl triazole binding station closer to its butyl groups. This directional shuttling presumably originates from charge repulsion and an …

Tapaustutkimus kontrollien kehittämisestä talouden prosesseissa SOX:n vaatimusten pohjalta tietojärjestelmien näkökulmasta

2007

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

2020

B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways…

McRock at SemEval-2022 Task 4: Patronizing and Condescending Language Detection using Multi-Channel CNN, Hybrid LSTM, DistilBERT and XLNet

2022

In this paper we propose four deep learning models for the task of detecting and classifying Patronizing and Condescending Language (PCL) using a corpus of over 13,000 annotated paragraphs in English. The task, hosted at SemEval-2022, consists of two different subtasks. The Subtask 1 is a binary classification problem. Namely, given a paragraph, a system must predict whether or not it contains any form of PCL. The Subtask 2 is a multi-label classification task. Given a paragraph, a system must identify which PCL categories express the condescension. A paragraph might contain one or more categories of PCL. To face with the first subtask we propose a multi-channel Convolutional Neural Network…

TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies

2009

AIM: To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors, in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand (TRAIL), on overcoming TRAIL resistance in hepatocellular carcinoma (HCC) and to study the efficacy of agonistic TRAIL antibodies, as well as the commitment of antiapoptotic BCL-2 proteins, in TRAIL-induced apoptosis. METHODS: Surface expression of TRAIL receptors (TRAIL-R1-4) and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analyzed by flow cytometry and Western blotting, respectively. Knock-down of MCL-1 and BCL-xL was performed by transfecting specific small interfering RNA…

Ergodicity for a stochastic Hodgkin–Huxley model driven by Ornstein–Uhlenbeck type input

2013

We consider a model describing a neuron and the input it receives from its dendritic tree when this input is a random perturbation of a periodic deterministic signal, driven by an Ornstein-Uhlenbeck process. The neuron itself is modeled by a variant of the classical Hodgkin-Huxley model. Using the existence of an accessible point where the weak Hoermander condition holds and the fact that the coefficients of the system are analytic, we show that the system is non-degenerate. The existence of a Lyapunov function allows to deduce the existence of (at most a finite number of) extremal invariant measures for the process. As a consequence, the complexity of the system is drastically reduced in c…

Utopijas un antiutopijas no T.Mora līdz S.Kolinsai

2015

Šajā darbā ir aprakstīta utopijas žanra attīstība gadsimtu gaitā, sākot no pirmajiem grieķu darbiem līdz antiutopijas daiļliteratūrai mūsdienās, iekļaujot vēl arī salīdzinošo analīzi trīs slaveniem utopijas un antiutopijas žanra darbiem, minot galvenās žanru iezīmes un analizējot tās attiecīgajās grāmatās. Šī darba mērķis ir izpētīt vēsturi un galvenos žanra autorus, svarīgākos notikumus un pagrieziena punktus tā attīstībā un esošo situāciju mūsdienās. Lai apkopotu nepieciešamo informāciju, tika pielietota literatūras pētījumu metode un visa iegūtā informācija par žanra attīstību ir atrodama šajā darbā, jo tēmas izpēte ir bijusi veiksmīga. Iegūtā informācija tiek izmantota arī, lai salīdzin…

Algorithms for Pallet Building and Truck Loading in an Interdepot Transportation Problem

2016

This paper deals with the problem of a logistics company that has to serve its customers by first putting the products on pallets and then loading the pallets into trucks. Besides the standard geometric constraints of products not overlapping each other and not exceeding the dimensions of pallets and trucks, in this real problem, there are many other constraints, related to the total weight of the load, the maximum weight supported by each axle, and the distribution of the load inside the truck. Although the problem can be decomposed into two phases, pallet loading and truck loading, we have taken a combined approach, building and placing pallets at the same time. For each position in the t…