Search results for "XOS"
showing 10 items of 414 documents
Circular RNA in Exosomes
2018
Circular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called “back-splicing”. These molecules show multiple functions, by acting as modulators of gene and miRNA expression, and may have a role in several biological processes, such as cell proliferation and invasion with, tumour development and progression, and in several mechanisms underlying other diseases. Their presence has been shown to be abundant in several body fluids such as blood and saliva. Based on their biogenesis mechanism, cir- cRNAs may be categorized into five classes: exonic circRNAs, intronic circRNAs…
Diving into exoplanets: Are water seas the most common?
2019
One of the basic tenets of exobiology is the need for a liquid substratum in which life can arise, evolve, and develop. The most common version of this idea involves the necessity of water to act as such a substratum, both because that is the case on Earth and because it seems to be the most viable liquid for chemical reactions that lead to life. Other liquid media that could harbor life, however, have occasionally been put forth. In this work, we investigate the relative probability of finding superficial seas on rocky worlds that could be composed of nine different, potentially abundant, liquids, including water. We study the phase space size of habitable zones defined for those substance…
Prebiotic effect of xylooligosaccharides produced from birchwood xylan by a novel fungal GH11 xylanase.
2017
34 p.-4 fig.-1 tab.
Changes in carbohydrate metabolism in Plasmopara viticola-infected grapevine leaves.
2011
International audience; The oomycete Plasmopara viticola is responsible for downy mildew, a severe grapevine disease. In infected grapevine leaves, we have observed an abnormal starch accumulation at the end of the dark period, suggesting modifications in starch metabolism. Therefore, several complementary approaches, including transcriptomic analyses, measurements of enzyme activities, and sugar quantification, were performed in order to investigate and to understand the effects of P. viticola infection on leaf starch and-to a larger extent-carbohydrate metabolism. Our results indicate that starch accumulation is associated with an increase in ADP-glucose pyrophosphorylase (AGPase) activit…
Determining stingray movement patterns in a wave-swept coastal zone using a blimp for continuous aerial video surveillance
2020
Stingrays play a key role in the regulation of nearshore ecosystems. However, their movement ecology in high-energy surf areas remains largely unknown due to the notorious difficulties in conducting research in these environments. Using a blimp as an aerial platform for video surveillance, we overcame some of the limitations of other tracking methods, such as the use of tags and drones. This novel technology offered near-continuous coverage to characterise the fine-scale movements of stingrays in a surf area in Kiama, Australia, without any invasive procedures. A total of 98 stingray tracks were recorded, providing 6 h 27 min of movement paths. The tracking data suggest that stingrays may u…
Improved Active Disturbance Rejection Control for Trajectory Tracking Control of Lower Limb Robotic Rehabilitation Exoskeleton.
2020
Neurological disorders such as cerebral paralysis, spinal cord injuries[acronym](SCI), and strokes, result in the impairment of motor control and induce functional difficulties to human beings like walking, standing, etc. Physical injuries due to accidents and muscular weaknesses caused by aging [english]affectsaffect people and can cause them to lose their ability to perform daily routine functions. In order to help people recover or improve their dysfunctional activities and quality of life after accidents or strokes, assistive devices like exoskeletons and orthoses are developed. Control strategies for control of exoskeletons are developed with the desired intention of improving the qual…
Non-linear active disturbance rejection control for upper limb rehabilitation exoskeleton
2020
Trajectory tracking in upper limb rehabilitation exercises is utilized for repeatability of joint movement to improve the patient’s recovery in the early stages of rehabilitation. In this article, non-linear active disturbance rejection control as a combination of non-linear extended-state observer and non-linear state error feedback is used for the sinusoidal trajectory tracking control of the two-link model of an upper limb rehabilitation exoskeleton. The two links represent movements like flexion/extension for both the shoulder joint and the elbow joint in the sagittal plane. The Euler–Lagrange method was employed to acquire a dynamic model of an upper limb rehabilitation exoskeleton. T…
The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities
2020
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which is largely due to their secretion of molecules with immunomodulatory properties. Although the soluble components of helminth secretions have been extensively studied, the discovery that helminths release extracellular vesicles (EVs) has added further complexity to the host-parasite interaction. Whilst several studies have begun to characterise the molecules carried by helminth EVs, work aimed at investigating their biological functions has been hindered by a lack of helminth-specific EV markers. To begin to address this, we summarised helminth EV literature to date. With a focus on the protein and mi…
Immunosuppressive profiles in liquid biopsy at diagnosis predict response to neoadjuvant chemotherapy in triple-negative breast cancer.
2020
Background: Triple-negative breast cancer (TNBC) is characterised by high pathological complete response to neoadjuvant chemotherapy (NAC). However, refractory and poor NAC responders still face very poor outcome, emphasising the urgent need for tools that facilitate identification of these patients, so that surgery or alternatives to NAC are considered early in the treatment protocol. Materials and methods: We combined metabolomics, exosome circulating miRNAs and flow cytometry experimental approaches in TNBC patients at diagnosis with immunohistochemistry in needle biopsy tumours to generate NAC-response predictive models. We also co-cultured and studied crosstalk between isolated patient…
Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate c…
2017
Abstract Background Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the bloodstream incorporated into extracellular vesicles (EVs) and ribonucleoprotein complexes. However, it is still debated if EVs contain biologically meaningful amounts of miRNAs and may provide a better source of miRNA biomarkers than whole plasma. The aim of this study was to systematically compare the diagnostic potential of prostate cancer-associated miRNAs in whole plasma and in plasma EVs. Methods RNA was isolated from whole plasma and plasma EV samples from a well characterised cohort of 50 patient with …