Search results for "XOS"

Liquid Biopsy in Gynecological Cancers

2017

Gynecological cancers originate in woman’s reproductive organs, including ovarian, uterine or endometrial, cervical, vulvar, and vaginal cancers. These tumors are a leading health problem for women accounting for more than 20% of new cases and cancer-related deaths worldwide. Gynecological cancers are characterized by an aggressive biological behavior with a clinical presentation often in advanced stage of disease. This chapter will focus on the potential role of the novel molecular approaches based on liquid biopsy in detecting occult disease, monitoring the progression and identifying treatment-resistance in gynecological cancer patients. The ability to detect circulating tumor DNA (ct-DN…

A rare case of a giant cervical osteochondroma

2016

Background: Osteochondroma or osteocartolaginous exostosis is the most common benign tumor of bone. They account for 35% to 50% of benign bone neoplasms and 10% to 15% of all primary bone tumors. Usually these tumors are found in the appendicular skeleton, especially in the metadiaphyseal region of long bones. Spinal osteochondromas, however, are uncommon especially at cervical level. Clinical presentation: We report the case of a 16 year old boy presenting a hard, gradually progressing, large swelling mass, over the posterior part of the neck causing pain. Radiological images revealed a giant solitary osteochondroma arising from C3 to C6 laminae. The patient underwent complete surgical exc…

Colon cancer cell-derived exosomes modulate macrophage immunosuppressive phenotype associated to PD-L1 expression

Compendium historiae Batavicae : a Iulio Caesare usque ad haec tempora / auctore Antonio Thysio... ; accessere, praeter duos ejusdem discursus orator…

1652

Antep. grav. Sign.: a-c8, A-Z8, Aa-Gg8

Belgii Confederati Respublica seu Gelriae, Holland, Zeland, Traject, Fris, Transisal. Groning chorographica politicaque descriptio

1630

Sign.: *8, A-Z8 Port. grav. amb els esc. de les regions dels Païxos Baixos

Molecular chaperones expression levels and localization in non-tumoral and tumoral thyroid tissues

2018

Papillary thyroid carcinoma (PTC) is the most frequently occurring subtype of thyroid cancer. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normality and pathology. Recent data indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment(1). Heat Shock Protein (HSPs) are often overexpressed during carcinogenesis and different studies shown that they can be released by tumors cells and that the mechanism of release is mediated by EXs pathway. In this project we performed an immunomorphological study to investigate Hsp60, 90,70,27 levels expression profile…

Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review

2019

Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging, is a common biological factor responsible for the decline and beginning of the disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of …

Promoção da saúde: O renascimento de uma ideologia

2004

A concepção actual de promoção de saúde, educação para a saúde e prevenção da doença é suportada por ideologias algo adulteradas pela realidade social. Tendo em conta a proliferação epistemológica destes conceitos no final do século XX pretende-se, no presente artigo, elaborar uma reflexão crítica em torno das múltiplas racionalidades estratégicas em que os conceitos se organizam, bem como, abordar os paradoxos que se instalam ao nível dos determinantes biopsicossociais dos comportamentos salutogénicos. Partilhando responsabilidades, os profissionais de saúde, devem, colectiva e proactivamente, desempenhar um papel significativo como promotores de saúde, modelando e reforçando o significado…

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

2015

Bone disease is the most frequent complication in multiple myeloma (MM) resulting in osteolytic lesions, bone pain, hypercalcemia and renal failure. In MM bone disease the perfect balance between bone-resorbing osteoclasts (OCs) and bone-forming osteoblasts (OBs) activity is lost in favour of OCs, thus resulting in skeletal disorders. Since exosomes have been described for their functional role in cancer progression, we here investigate whether MM cell-derived exosomes may be involved in OCs differentiation. We show that MM cells produce exosomes which are actively internalized by Raw264.7 cell line, a cellular model of osteoclast formation. MM cell-derived exosomes positively modulate pre-…

Ultrastructural pathology of dermal axons and Schwann cells in lysosomal diseases

1988

Skin tissue specimens, obtained from 60 patients afflicted with a diverse range of lysosomal disorders revealed two groups of lesions within dermal axons, largely unmyelinated ones, particularly within axonal terminals: (1) non-specific mitochondria and dense bodies often enlarging the axonal terminal; and (2) disease-specific lysosomal residual bodies, the latter less frequent depending on the incidence and type of lysosomal disorders, i.e., largely only seen in GM2-gangliosidosis due to hexosaminidase A deficiency and mucolipidosis IV, while the spectrum of lysosomal residual bodies in Schwann cells appeared more variegated, especially due to the occurrence of vacuolar lysosomal residual …