6533b82efe1ef96bd1293e2d

RESEARCH PRODUCT

Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review

Giuseppe CammarataSimona TavernaAlessia Lo CurtoTiziana Di ChiaraGiovanni DuroGiuseppina Candore

subject

ParabiosisInflammationexosomesDiseaseBiologyBioinformaticsExosomeMice03 medical and health sciences0302 clinical medicineage-related diseasesDrug DiscoverymicroRNAmedicineAnimalsHumansCirculating MicroRNAEpigenetics030304 developmental biologySettore MED/04 - Patologia GeneraleInflammationPharmacology0303 health sciencesRegeneration (biology)agingmiR-126.PhenotypeCirculating miRNAs aging exosome inflammation mediators age-related diseases miR-21-5p miR-126.inflammation mediatorsModels AnimalmiRNAsmiR-21-5pmedicine.symptom030217 neurology & neurosurgery

description

Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging, is a common biological factor responsible for the decline and beginning of the disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status of multiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging.

yearjournalcountryeditionlanguage
2019-01-01Current Pharmaceutical Design
https://doi.org/10.2174/1381612825666191119091644