Search results for "XOS"
showing 10 items of 414 documents
A Carbohydrate-Based Julia–Kocienski Reagent for Syntheses of Chain-Extended and C-Linked Saccharides
2014
The carbohydrate-derived Julia–Kocienski reagent 2-{[(3aS,4S,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methylsulfonyl}-1,3-benzothiazole (6) was prepared from d -ribose and investigated in the eponymous olefination. The base-promoted generation of the Julia anion induced a rearrangement to the corresponding l -lyxose epimer 2-{[(3aS,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methylsulfonyl}-1,3-benzothiazole (12), which reacted readily with aldehydes and with a gluconolactone. The latter reaction furnished an exo-glycal-linked C-diglycoside.
Base-assisted synthesis of 4-pyridinate gold(I) metallaligands: a study of their use in self-assembly reactions
2021
Made available in DSpace on 2021-06-25T12:16:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-06 Ministerio de Economia y Competitividad (MINECO/FEDER) of Spain Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The synthesis of di- and tritopic gold(I) metallaligands of the type [(Au4-py)(2)(mu(2)-diphosphane)] (diphosphane = bis(diphenylphosphanyl)isopropane or dppip (1), 1,2-bis(diphenylphosphanyl)ethane or dppe (2), 1,3-bis(diphenylphosphanyl)propane or dppp (3) and 1,4-bis(diphenylphosphanyl)butane or dppb (4)) and [(Au4-py)(3)(mu(3)-triphosphane)] (triphosphane = 1,1,1-tris(diphenylphosph…
Modèle des voies réflexes et cérébelleuses, permettant le calcul de fonctions inverses et la commande d'un segment mécanique mobile
2004
14/07/2004; La commande et le contrôle des mouvements des membres par les voies cérébelleuses et réflexes sont modélisées au moyen d'un circuit dont la structure est déduite de contraintes fonctionnelles. 1/ La première contrainte est que les mouvements rapides des membres doivent être précis, quoiqu'ils ne puissent pas être commandés en boucle fermée au moyen de signaux sensoriels. Les voies qui préparent les ordres moteurs doivent donc contenir des fonctions inverses approximées des fonctions biomécaniques du membre et des muscles. Or une telle fonction peut être calculée au moyen de boucles de rétroaction parallèles, dont la structure est comparable à l'anatomie des voies cérébelleuses. …
Fabry Disease With Concomitant Lewy Body Disease
2019
AbstractAlthough Gaucher disease can be accompanied by Lewy pathology (LP) and extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another progressive multisystem lysosomal storage disorder. We aimed to elucidate the distribution patterns of FD-related inclusions and LP in the brain of a 58-year-old cognitively unimpaired male FD patient suffering from predominant hypokinesia. Immunohistochemistry (CD77, α-synuclein, collagen IV) and neuropathological staging were performed on 100-µm sections. Tissue from the enteric or peripheral nervous system was unavailable. As controls, a second cognitively unimpaired 50-year-old male FD patient without LP or motor symptoms and 3…
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicl…
2018
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines fo…
Exosome investigation: the approach of electron microscopy
2018
A mixture of cell-derived extracellular vesicles (EVs) are contained in the extracellular environment, in particular body fluids. The EVs originate from the lipid membranes of a variety of cells and are engaged in the intercellular communication in a broad range of physiological processes and pathological conditions. The smallest type of EVs, exosomes, with sizes ranging from 40 nm up to approximately 100 nm in diameter, originate from the endosome. Exosomes are natural nanoshuttles that are capable of delivering their cargo of RNA, lipids, and proteins to cells in close proximity and to distant cellular destinations. There is a rapidly growing interest in utilizing exosomes present in pati…
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
2014
Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter activity. Shown by pharmacological and siRNA-mediated inhibition, the observed effects are SIRT1-independent. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, a central post-transcriptional regul…
CCDC 1415863: Experimental Crystal Structure Determination
2016
Related Article: Moritz Schubert, Kathrin Wehming, Anton Kehl, Martin Nieger, Gregor Schnakenburg, Roland Fröhlich, Dieter Schollmeyer, Siegfried R. Waldvogel|2016|Eur.J.Org.Chem.|2016|60|doi:10.1002/ejoc.201501384
Discursos sobre las mujeres en la cultura de la Ilustración: conexiones europeas y peculiaridades hispánicas
1996
La Ilustración representó en muchos sentidos un periodo de quiebra de las estructuras del pensamiento tradicional y de liberación de posibilidades críticas en la concepción de las relaciones sociales y las identidades individuales. Una de las vertientes de la sociedad y la cultura que acusó el cambio fue la representación de las relaciones entre los sexos y las identidades masculinas y femeninas.
Physical exercise induces rapid release of small extracellular vesicles into the circulation
2015
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and EVs were isolated from blood plasma samples taken before, immediately after and 90 min after exercise. Small EVs with the size of 100–130 nm, that carried proteins character…