Search results for "Z1"

AP5Z1/SPG4 8 frequency in autosomal recessive and sporadic spastic paraplegia

2014

Hereditary spastic paraplegias (HSP) constitute a rare and highly heterogeneous group of neurodegenerative disorders, defined clinically by progressive lower limb spasticity and pyramidal weakness. Autosomal recessive HSP as well as sporadic cases present a significant diagnostic challenge. Mutations in AP5Z1, a gene playing a role in intracellular membrane trafficking, have been recently reported to be associated with spastic paraplegia type 48 (SPG48). Our objective was to determine the relative frequency and clinical relevance of AP5Z1 mutations in a large cohort of 127 HSP patients. We applied a targeted next-generation sequencing approach to analyze all coding exons of the AP5Z1 gene. …

Los archivos de distrito en Portugal: memoria administrativa, histórica y social

2018

Se presenta un análisis de la evolución histórico-jurídi ca de los Archivos de Distrito (AD) portugueses, como instituciones que asumen la salvaguarda del patrimo nio público-administrativo del país. Para ello se revisa la bibliografía más relevante sobre el tema, así como la documentación histórica, legal y política, describien do su historia desde sus orígenes y los nuevos caminos que se van trazando, en relación con el aumento de la accesibilidad a la documentación que gestionan y a las nuevas estrategias de difusión de la información entre la ciudadanía. Todo ello en el marco de las distintas ini ciativas de modernización administrativa y las nuevas tecnologías disponibles.

Presentación del monográfico "El balance social en la economía social"

2001

Social capital and economic growth in Europe: nonlinear trends and heterogeneous regional effects

2016

After two decades of academic debate on the social capital-growth nexus, discussion still remains open. Most of the literature so far, however, has followed the one-size-its-all approach, neglecting that the great disparities across geographical units might have implications in this relationship. This article analyzes the role of two social capital indicators on the growth of 237 European regions in the period 1995–2007 by implementing a set of both parametric and non- parametric regressions. Whereas the former impose a linear functional form for the parameters, the latter relax this assumption providing a flexible frame in which the functional form is given by the data. The technique also …

Heterogeneous network games: Conflicting preferences

2013

Proceeding at: 2nd Annual UECE Lisbon Meeting: Game Theory and Applications, took place 2010, November, 4-6, in Lisbon (Portugal). The event Web site http://pascal.iseg.utl.pt/~uece/lisbonmeetings2010/ In many economic situations, a player pursues coordination or anti-coordination with her neighbors on a network, but she also has intrinsic preferences among the available options. We here introduce a model which allows to analyze this issue by means of a simple framework in which players endowed with an idiosyncratic identity interact on a social network through strategic complements or substitutes. We classify the possible types of Nash equilibria under complete information, finding two thr…

Un análisis bibliométrico en el área de la Medicina: colaboración científica entre Brasil y España (2002-2011)

2016

RESUMENEsta investigación tiene por objetivo analizar la evolución temporal de la producción científica en colaboración entre Brasil y España en el área de la Medicina, en el periodo 2002-2011, además de identificar las instituciones y países más productivos y representar y analizar las redes de colaboración institucional entre los países colaboradores. Como fuente de información se utilizó Scopus, por considerarla como la principal base de datos multidisciplinar y con mayor cobertura geográfica. Los documentos analizados se han limitado a los artículos originales. Se recuperaron 1 121 artículos científicos, con un total de 13 906 firmas. Se calculó, para cada año, la tasa de crecimiento an…

Developing a Conceptual Framework for Investigating Communication Supporting Community Resilience

2015

In crisis management, cooperation within the response network is seen as crucial. Usually, this network refers to authorities and nongovernmental organizations, such as the Red Cross. However, the authors argue that to improve societal resilience one should take a broader overview of the actors involved in crisis preparedness and mitigation, and also include the public. With this in mind, the role of communication is scrutinized and a conceptual framework developed as a starting point for further investigation into how communication may be developed to strengthen a community approach to crisis management that includes citizen groups in the broader response network. A model is presented alon…

Towards Sustaining Levels of Reflective Learning: How Do Transformational Leadership, Task Interdependence, and Self-Efficacy Shape Teacher Learning …

2015

Whereas cross-sectional research has shown that transformational leadership, task interdependence, and self-efficacy are positively related to teachers’ engagement in reflective learning activities, the causal direction of these relations needs further inquiry. At the same time, individual teacher learning might play a mutual role in strengthening school-level capacity for sustained improvement. Building on previous research, this longitudinal study therefore examines how transformational leadership, task interdependence, self-efficacy, and teachers’ engagement in self-reflection mutually affect each other over time. Questionnaire data gathered on three measurement occasions from 655 Dutch …

CULTURE, SUSTAINABLE URBAN DEVELOPMENT AND URBAN REGENERATION

2014

Concerns about the conflict between economy, development on one hand and urban cultural heritage on the other hand, have made the urban development to be lately one of the most important themes at European level. Also, another issue of concern is social equity, aiming to strike a balance between economic development and equal access to culture for all generations of inhabitants of urban communities. Basically, ensuring these balances between urban cultural heritage, economy and social equity we express the essence of the concept of sustainable development from the perspective of culture. Urbanization is an ongoing process in all the cities of the world, but urban cultural heritage is a cru…

Social capital and political participation

2010

This paper analyzes the determinants of social capital, as generalized trust, from a microeconomic perspective. We review previous results at the aggregate level and test their significance in our setup. Specifically we aim at testing the role of political participation and the quality of institutions. The empirical work relies on microeconomic data from the 2008 wave of the European Social Survey, including 21 European countries and roughly 41,000 observations on a wide set of socio-economic and political variables. Preliminary results underline the role of political participation in the accumulation of generalized trust, while data are consistent with institutional quality being a consequ…