Search results for "ZOL"

showing 10 items of 4792 documents

Coordination versatility of 1,3-bis[3-(2-pyridyl)pyrazol-1-yl]propane: Co(II) and Ni(II) complexes

2006

Abstract The ligand 1,3-bis[3-(2-pyridyl)pyrazol-1-yl]propane (L8) has afforded six-coordinate monomeric and dimeric complexes [(L8)CoII(H2O)2][ClO4]2 (1), [(L8)NiII(MeCN)2][BPh4]2 (2), [(L8)NiII(O2CMe)][BPh4] (3), and [ ( L 8 ) 2 Co 2 II ( μ - O 2 CMe ) 2 ] [ BPh 4 ] 2 ( 4 ) . The crystal structures of 1, 2 · MeCN, 3, and 4 revealed that the ligand L8 is flexible enough to expand its coordinating ability by fine-tuning the angle between the chelating fragments and hence folds around cobalt(II)/nickel(II) centers to act as a tetradentate chelate, allowing additional coordination by two trans-H2O, cis-MeCN, and a bidentate acetate affording examples of distorted octahedral Co II N 2 ( pyridy…

DenticityStereochemistryLigandchemistry.chemical_elementCrystal structurePyrazoleInorganic Chemistrychemistry.chemical_compoundNickelCrystallographychemistryOctahedronMaterials ChemistryPhysical and Theoretical ChemistryAcetonitrileCobaltInorganica Chimica Acta
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Ferromagnetic coupling in the malonato-bridged copper(ii) chains [Cu(Im)2(mal)]nand [Cu(2-MeIm)2(mal)]n(H2mal = malonic acid, Im = imidazole and 2-Me…

2002

Two new malonato-bridged copper(II) complexes of formula [Cu(Im)2(mal)]n (1) and [Cu(2-MeIm)2(mal)]n (2) (Im=imidazole, 2-MeIm=2-methylimidazole and mal=malonate dianion) have been prepared and their structures solved by X-ray diffraction methods. The [Cu(Im)2(mal)] and [Cu(2-MeIm)2(mal)] neutral entities act as monodentate ligands towards the adjacent copper(II) units through one of the two carboxylate groups, the OCO bridge exhibiting an anti-anti conformation. The environment of each copper atom in 1 and 2 is distorted square pyramidal: two carboxylate oxygen atoms from a bidentate malonate and two nitrogen atoms from two imidazole (1) or 2-methylimidazole (2) ligands form the equatorial…

DenticityStereochemistrychemistry.chemical_elementGeneral Chemistry2-MethylimidazoleMalonic acidCopperCatalysisSquare pyramidal molecular geometrychemistry.chemical_compoundCrystallographyMalonatechemistryMaterials ChemistryImidazoleCarboxylateNew J. Chem.
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A Co(III) complex of carbonic anhydrase inhibitor methazolamide and the amino-imino ‘aib’ ligand formed by reaction of acetone and ammonia

1993

Abstract Reaction of Co(NO 3 ) 2 ·6H 2 O with methazolamide {[ N -(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3 H )-ylidene)acetamide] (Hmacm)} and ammonia in acetone to produce [Co(methazolamidate)(2-methyl-2-amino-4-iminopentane) 2 (NH 3 )](NO 3 ) 2 ·2H 2 O is described. The ligand 2-methyl-2-amino-4-iminopentane (aib) is the product obtained from the condensation of two ammonia and two acetone molecules. The complex crystallizes in the monoclinic space group P 2 1 / c with a =16.713(5), b =9.180(1), c =20.273(1) A, β=97.44(4)° for Z =4. The R value is 0.081 for 2150 significant reflections. The Co(III) ion exhibits a nearly regular octahedral arrangement with the CoN bond distances in the …

DenticitybiologyLigandStereochemistrymedicine.drug_classImineMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundDeprotonationchemistryCarbonic anhydraseMaterials Chemistrymedicinebiology.proteinCarbonic anhydrase inhibitorPhysical and Theoretical ChemistryMethazolamideAcetamidemedicine.drugInorganica Chimica Acta
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Direct arylation of heterocycles: the performances of ferrocene-based polyphosphane ligands in palladium-catalyzed C-H bond activation

2010

International audience; The palladium-catalyzed direct arylation of alkylated- furan, thiophene, and thiazole and benzoxazole heterocycles with electronically and sterically deactivated bromoarenes was selectively and efficiently promoted by ferrocenyl polyphosphanes. In this C[BOND]H bond activation reaction of heteroaromatics, the performances of polydentate di-, tri-, and tetraphosphane ligands were compared, showing that the triphosphane 1,1′,2-tris(diphenylphosphino)-4-tert-butylferrocene 3 was the most effective for the coupling. The introduction of more electron-donating (iPr) or electron-withdrawing (furyl) groups on the phosphorus atoms did not improve the ligand performances. The …

Denticitychemistry.chemical_elementCH activation010402 general chemistry01 natural sciencesMedicinal chemistryCatalysisInorganic Chemistrychemistry.chemical_compound[ CHIM.CATA ] Chemical Sciences/CatalysisThiopheneOrganic chemistryChelation[CHIM.COOR]Chemical Sciences/Coordination chemistryPhysical and Theoretical ChemistryThiazoleheterocycles010405 organic chemistryLigandOrganic Chemistry[ CHIM.COOR ] Chemical Sciences/Coordination chemistry[CHIM.CATA]Chemical Sciences/CatalysisBenzoxazolepalladiumhomogeneous catalysis0104 chemical sciencesTriphosphanechemistryligands effectsPalladium
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Magneto-structural study on a series of rhenium(IV) complexes containing biimH2, pyim and bipy ligands

2008

Abstract Three rhenium(IV) mononuclear compounds of formulae [ReCl4(biimH2)] · 2DMF (1), [ReCl4(pyim)] · DMF (2) and [ReCl4(bipy)] (3) (biimH2 = 2,2′-biimidazole, pyim = 2-(2′-pyridyl)imidazole, bipy = 2,2′-bipyridine and DMF = N,N-dimethylformamide) have been prepared and characterized. The crystal structure of 2 was determined by single crystal X-ray diffraction. Compound 2 crystallizes in the monoclinic system with P21/c as space group. The rhenium atom is six-coordinated by four Cl atoms and two nitrogen atoms from a bidentate pyim ligand [average values of Re–Cl and Re–N bonds lengths being 2.330(2) and 2.117(4) A, respectively]. The magnetic properties were investigated from susceptib…

Denticitychemistry.chemical_elementCrystal structureRhenium22'-BipyridineInorganic Chemistrychemistry.chemical_compoundCrystallographychemistryMaterials ChemistryImidazoleAntiferromagnetismPhysical and Theoretical ChemistrySingle crystalMonoclinic crystal systemPolyhedron
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Construction of Coordination Polymers from Semirigid Ditopic 2,2′-Biimidazole Derivatives: Synthesis, Crystal Structures, and Characterization

2017

Eight coordination polymers (CPs), {[Ag(L1)]ClO4}n (1), {[Ag(L2)1.5]ClO4·C2H3N}n (2a), {[Ag(L2)]ClO4}n (2b), [Zn(L1)Cl2]n (3), {[Zn(L2)Cl2]·CHCl3}n (4), {[Cu(L1)2Cl]Cl·H2O}n (5), [Cu2(L2)(μ-Cl)2]n (6), and [Cu4(L2)(μ-Cl)4]n (7) were synthesized via self-assembly of corresponding metal ions and biimidazole based ditopic ligands, 1,1′-bis(pyridin-3-ylmethyl)-2,2′-biimidazole L1 and 1,1′-bis(pyridin-4-ylmethyl)-2,2′-biimidazole L2. These ligands possess conformational flexibility and two pairs of coordination sites: pyridine nitrogen (NPy) atoms and imidazole nitrogen (NIm) atoms. Depending on the metal center in CPs, the biimidazole compounds act as tetra- (1, 7), tri- (2a), or bidentate (2a,…

Denticitykemia010405 organic chemistryStereochemistryMetal ions in aqueous solutionCenter (category theory)General ChemistryCrystal structureNuclear magnetic resonance spectroscopy010402 general chemistryCondensed Matter Physics01 natural sciences0104 chemical sciencescoordination polymersCrystallographychemistry.chemical_compoundchemistryPyridineImidazoleGeneral Materials Sciencepolymeeritta116Single crystalpolymersCrystal Growth & Design
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Mononuclear Perfluoroalkyl-Heterocyclic Complexes of Pd(II): Synthesis, Structural Characterization and Antimicrobial Activity

2020

Two mononuclear Pd(II) complexes [PdCl2(pfptp)] (1) and [PdCl2(pfhtp)] (2), with ligands 2-(3-perfluoropropyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfptp) and 2-(3-perfluoroheptyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfhtp), were synthesized and structurally characterized. The two complexes showed a bidentate coordination of the ligand occurring through N atom of pyridine ring and N4 atom of 1,2,4-triazole. Both complexes showed antimicrobial activity when tested against both Gram-negative and Gram-positive bacterial strains.

Denticityperfluoroalkyl heterocyclic ligandsSpectrophotometry InfraredStereochemistryProton Magnetic Resonance SpectroscopyPharmaceutical ScienceMicrobial Sensitivity TestsSettore BIO/19 - Microbiologia GeneraleRing (chemistry)Analytical Chemistrylcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryAnti-Infective AgentsHeterocyclic CompoundsDrug DiscoveryPyridinemononuclear palladium complexesSettore BIO/06 - Anatomia Comparata E CitologiaPhysical and Theoretical ChemistrytriazolesFluorocarbonsantimicrobial activityBacteriaChemistryLigandCommunicationnarcosisOrganic ChemistrySettore CHIM/06 - Chimica OrganicaDNAAntimicrobialSettore CHIM/03 - Chimica Generale E InorganicaChemistry (miscellaneous)Molecular MedicinePalladiumPlasmidsMolecules
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[1,2,3]Triazolo[1,5-a]pyridines. A theoretical (DFT) study of the ring-chain isomerization

2008

The ring opening isomerization of [1,2,3]triazolo[1,5-a]pyridines to the corresponding 2-pyridyl derivatives has been studied by means of DFT calculations at the B3LYP/6-31+G(d,p) computational level. The effect of the substitution as well as those of protonation, deprotonation, and lithiation on different positions has been studied. The electronic characteristics of the optimized structures have been analyzed by means of the Atoms In Molecules (AIM), Electron Localization Function (ELF), Molecular Electrostatic Potential (MEP), and Natural Bond Orbital (NBO) methodologies. © 2008 Elsevier Ltd. All rights reserved.

DeprotonationComputational chemistryChemistryOrganic ChemistryDrug DiscoveryAtoms in moleculesTriazolopyridineProtonationRing (chemistry)BiochemistryIsomerizationElectron localization functionNatural bond orbital
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Detection of banned drugs in sport by micellar liquid chromatography

1992

Abstract A rapid method for the determination of banned drugs in sport (including stimulants, anabolic steroids and diuretics) based on micellar liquid chromatography is proposed. The mobile phase is an aqueous solution of a surfactant (sodium dodecyl sulphate in this instance) and the stationary phase is octadecylsilica. The retention parameters of the drugs were established and the effect of a mobile phase organic modifier on the chromatographic behaviour of the compounds was studied. Improvements in efficiency were achieved by control of the temperature of the mobile phase. This method allows the direct injection of urine samples for the determination of drugs excreted free in urine: ami…

Detection limitAmiphenazoleChromatographyMethoxyphenamineChemistryMetandienoneClostebolBiochemistryAnalytical Chemistrychemistry.chemical_compoundMicellar liquid chromatographymedicineEnvironmental ChemistryEphedrineSpectroscopyPhenylpropanolaminemedicine.drugAnalytica Chimica Acta
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Sequential-injection determination of traces of disodium phenyl dibenzimidazole tetrasulphonate in urine from users of sunscreens by on-line solid-ph…

2005

Abstract A sensitive and selective method to determine disodium phenyl dibenzimidazole tetrasulphonate (PDT) in the urine of sunscreen users, which is suitable for studies on body accumulation/excretion is proposed. On-line solid-phase extraction allows the analyte to be retained and subsequentely eluted, using a strong anion exchange (SAX) microcolumn. Standard addition calibration was carried out with only one standard. The wavelengths of excitation and emission were 330 and 454 nm, respectively. The method allows PDT to be determined in both, spiked and unspiked human urine samples, without any pre-treatment. Results obtained for spiked urine samples (40–200 ng ml −1 ) showed the accurac…

Detection limitAnalyteChromatographyChemistryElutionAdministration TopicalSkin AbsorptionClinical BiochemistryFluorescence spectrometryReproducibility of ResultsPharmaceutical ScienceUrineHydrogen-Ion ConcentrationAnalytical ChemistryExcretionSpectrometry FluorescenceStandard additionFlow Injection AnalysisDrug DiscoveryHumansBenzimidazolesSolid phase extractionSunscreening AgentsSpectroscopyJournal of Pharmaceutical and Biomedical Analysis
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